Houston Astros vs New York Yankees Prediction, Preview and Odds - 08/25/2026

Game Time: 7:05 pm ET, Tuesday, August 25, 2026

Venue:  Yankee Stadium, Bronx, NY

Where to Watch:  MLB TV

DraftKings:  Moneyline odds:  Astros +123, Yankees -149; Over/Under:  9 runs

Bet365:  Moneyline odds:  Astros +120, Yankees -145; Over/Under:  9 runs

BetMGM:  Moneyline odds:  Astros +120, Yankees -145; Over/Under:  9 runs

Houston Astros:  65-66 (1st place, AL West)

New York Yankees:  74-56 (2nd place, AL East)

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Houston Astros:  4-6 last 10

New York Yankees:  6-4 last 10

The Astros are entering this series off a loss and lost their 3-game series against the Athletics 2-1 in their last series. They enter this game with a 65-66 record overall and have a road record of 32-31. This is the series opener of a 3-game series with the Yankees on Tuesday and they have Monday off as a day of rest. Their offense ranks 10th in the MLB with a .727 OPS. Cristian Javier was their starting pitcher on Sunday while rookie pitcher Ethan Pecko is making his start in this game on Tuesday. He is 0-0 with a 4.91 ERA this season. His team won their last game this season with him making an appearance. In his last MLB regular season appearance, he allowed 2 ER, 0 HR, and 3 BB with 4 SO on 3 hits through 3.2 IP against the Los Angeles Angels.

The Yankees are entering this series off a win and won their 3-game series against the Toronto Blue Jays 2-1 in their last series. They enter this game with a 74-56 record overall and have a home record of 33-28. This is the 1st game of a 3-game series with the Astros on Tuesday and they have Monday off as a day of rest. Their offense ranks 18th in the MLB with a .716 OPS. Carlos Rodón was their starting pitcher on Sunday while Will Warren is making his start in this game on Tuesday. He is 8-6 with a 4.43 ERA this season. His team won their last 2 straight games this season with him making an appearance. In his last MLB regular season start, he allowed 2 earned runs, 1 homer, and 2 walks with 5 strikeouts on 3 hits through 4 innings pitched against the Baltimore Orioles.

The current betting odds have the Yankees listed as a favorite in this game according to Draftkings Sportsbook. The Yankees have looked really good in their games this season with their 74-56 record overall which has them right near the top of the AL East. They have been a good road team too with their 33-28 road record this year. Meanwhile, the Astros haven't looked great in their games this season with their 65-66 record overall, but that record has them right at the top of the AL West. They have looked better in their own ballpark too with their 32-31 home record this season. The Astros have been one of the hottest teams in the league over the last 2 months, but once they took the lead in their division, they couldn't really get ahead. Now they are still leading, but they have dipped back under .500 for the season and haven't looked great lately either, going 4-6 in their last 10 games. The Yankees have been getting hot lately though, going 6-4 in their last 10 games, and they are going to be motivated as they are just a series away from catching the Rays in 1st place in the AL. The Yankees are going with Warren in this one and he hasn't looked great this season. He is 8-6 with a 4.43 ERA, but lately he has looked a lot better. He is coming off another good start giving up 2 earned runs which has been a common theme for him lately. The team has also been having a ton of success with him, winning 2 games in a row now with him starting. The Astros are going with Pecko in this one and he hasn't looked great this year. He is 0-0 with a 4.91 ERA and has only made 1 career start. The Astros won that game, but he gave up 2 earned runs without getting through 4 innings and that is going to be an issue. The Astros have been in a big slump lately, giving up a ton of runs, while the Yankees have one of the best bullpens in MLB to help out Warren who has looked a lot better lately. The best way to place a bet here is on the Yankees to win this game. 

Astros Yankees Prediction:  Our MLB Pick for Tuesday, August 25, 2026 (7:05 pm ET start time) is Yankees 6 Astros 2.

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Houston Astros: 116-108 (+6.5 units) on the moneyline in road games. 84-76 (+27 units) on the moneyline as an underdog of +100 or higher. 109-100 (+7.7 units) on the moneyline when playing against a team with a winning record. 23-14 UNDER as a road underdog of +125 to +175.

New York Yankees: 272-202 (-16.6 units) on the moneyline in all games. 134-101 (-28.4 units) on the moneyline in home games. 229-160 (-23.5 units) on the moneyline as a favorite of -110 or higher. 42-25 UNDER when the money line is -100 to -150.

Houston Astros:  B. Matthews (CF) Sixty Day IL - Knee. M. Burrows (SP) Fifteen Day IL - Elbow. C. Correa (SS) Sixty Day IL - Ankle. B. Walter (RP) Sixty Day IL - Elbow.

New York Yankees:  R. Weathers (SP) Fifteen Day IL - Forearm. R. McMahon (3B) Ten Day IL - Thumb. M. Fried (SP) Fifteen Day IL - Elbow. K. Castro (RP) Fifteen Day IL - Elbow. A. Judge (RF) Sixty Day IL - Rib. G. Stanton (DH) Ten Day IL - Leg. C. Schmidt (SP) Sixty Day IL - Elbow.

“It’s not easy to take it, especially when the guys are showing up every day to the field prepared in the right way.” - Omar Lopez after his team’s loss against the A’s in their game on Sunday. 

“That’s why you still feel like it’s in there for him to get hot at the most important time of the year. He hasn’t had that stretch, that run of weeks where he’s a carrier. He can do so many things to take over a game on both sides of the ball, and today was a peek into that.” - Aaron Boone after his team’s win against the Blue Jays in their game on Sunday. 

Jeremy Peña (R) SS

Yordan Alvarez (L) DH

Isaac Paredes (R) 3B

Jose Altuve (R) 2B

Daulton Varsho (L) CF

Christian Walker (R) 1B

LaMonte Wade Jr. (L) LF

Cam Smith (R) RF

Christian Vázquez (R) C

Trent Grisham (L) CF

Ben Rice (L) DH

Luis García Jr. (L) 1B

Cody Bellinger (L) LF

George Lombard Jr. (R) SS

Spencer Jones (L) RF

Jazz Chisholm Jr. (L) 2B

Austin Wells (L) C

José Caballero (R) 3B

Batting Average:  Yordan Alvarez (.320)

Hits:  Yordan Alvarez (148)

Home Runs:  Yordan Alvarez (36)

RBI:  Yordan Alvarez (90)

Stolen Bases:  Cam Smith (10)

Wins:  Peter Lambert (8)

Saves:  Josh Hader (18)

ERA:  Josh Hader (0.84)

Batting Average:  George Lombard (.288)

Hits:  Ben Rice (116)

Home Runs:  Ben Rice (34)

RBI:  Ben Rice (82)

Stolen Bases:  Jazz Chisholm (34)

Wins:  Cam Schlittler (11)

Saves:  David Bednar (30)

ERA:  Yerry De los Santos (1.08)

Managers:

Houston Astros: Joe Espada (3rd season)

New York Yankees: Aaron Boone (9th season)