Houston Astros vs Chicago White Sox Prediction, Preview and Odds - 07/24/2026

Game Time: 7:40 pm ET, Friday, July 24, 2026

Venue:  Rate Field, Chicago, IL 

Where to Watch:  MLB TV

DraftKings:  Moneyline odds:  Astros +124, White Sox -150; Over/Under:  8.5 runs

Bet365:  Moneyline odds:  Astros +125, White Sox -150; Over/Under:  8.5 runs

BetMGM:  Moneyline odds:  Astros +125, White Sox -155; Over/Under:  8.5 runs

Houston Astros:  50-54 (3rd place, AL West)

Chicago White Sox:  54-47 (1st place, AL Central)

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Houston Astros:  4-6 last 10

Chicago White Sox:  7-3 last 10

The Astros are entering this series off a win and completed the sweep in their 3-game series against the Miami Marlins 3-0 in their last series. They enter this game with a 50-54 record overall and have a road record of 24-27. This is the series opener of a 3-game series with the White Sox on Friday and they have Thursday off as a day of rest. Their offense ranks 13th in the MLB with a .728 OPS. Peter Lambert was their starting pitcher on Wednesday while Spencer Arrighetti is making his start in this game on Friday. He is 7-5 with a 4.34 ERA this season. His team lost their last 6 straight games this season with him making an appearance. In his last MLB regular season appearance, he allowed 1 ER, 0 HR, and 4 BB with 6 SO on 1 hit through 5 IP against the Baltimore Orioles.

The White Sox are entering this series off a win and won their 3-game series against the Texas Rangers 2-1 in their last series. They enter this game with a 54-47 record overall and have a home record of 31-17. This is the 1st game of a 3-game series with the Astros on Friday and they have Thursday off as a day of rest. Their offense ranks 14th in the MLB with a .727 OPS. Anthony Kay was their starting pitcher on Wednesday while Davis Martin is making his start in this game on Friday. He is 9-5 with a 3.31 ERA this season. His team lost their last 3 straight games this season with him making an appearance. In his last MLB regular season start, he allowed 1 earned run, 0 homers, and 2 walks with 5 strikeouts on 4 hits through 5.2 innings pitched against the Toronto Blue Jays.

The current betting odds have the White Sox listed as a favorite in this game according to Draftkings Sportsbook. The White Sox have looked good in their games this season with their 54-47 record overall which has them right at the top of the AL Central. They have looked great in their own ballpark too with their 31-17 home record this season. Meanwhile, the Astros haven't looked great in their games this season with their 50-54 record overall which has them right in the middle of the AL West. They haven't been a great road team either with their 24-27 road record this year. The Astros were rolling into the All-Star break as they were well below .500 for most of the season and have put themselves back in the AL West race, but they are now 4-6 in their last 10 games and haven't looked great coming out of the break. The White Sox have looked great though as they are currently leading their division, now 7-3 in their last 10 games, and they have been rolling with one of the best offenses in MLB too. Martin is going to be on the mound for the White Sox in this one and he has looked great this season. He is 9-5 with a 3.31 ERA and he has been their ace this year. His team has had some trouble with him lately, losing 3 games in a row now with him starting, but that hasn't been a common theme for him this season and he is coming off another great start in which he gave up 1 earned run. The Astros are going with Arrighetti in this one and he hasn't looked great this year. He is 7-5 with a 4.34 ERA and the team has been having a lot of trouble with him lately. They have lost 6 games in a row now with him starting and even though he only gave up 1 earned run in his last start, that hasn't been a common theme for him lately. The White Sox have the momentum on their side right now and they are going to have the better pitching matchup too, so look for them to take advantage of that with the stronger offense. The best way to place a bet here is on the White Sox to win this game. 

Astros White Sox Prediction:  Our MLB Pick for Friday, July 24, 2026 (7:40 pm ET start time) is White Sox 7 Astros 1.

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Houston Astros: 80-73 (+25.7 units) on the moneyline as an underdog of +100 or higher. 105-97 (+6.4 units) on the moneyline when playing against a team with a winning record. 123-98 (+6.3 units) on the moneyline vs. an AL team with a slugging percentage .410 or worse on the season. 25-14 OVER when playing against a team with a winning record.

Chicago White Sox: 155-270 (-54.3 units) on the moneyline in all games. 87-123 (-12.1 units) on the moneyline in home games. 113-202 (-42.6 units) on the moneyline against right-handed starters. 43-25 OVER against right-handed starters.

Houston Astros:  B. Matthews (CF) Ten Day IL - Knee. M. Burrows (SP) Fifteen Day IL - Elbow. C. Correa (SS) Sixty Day IL - Ankle. H. Wesneski (RP) Sixty Day IL - Elbow. B. Walter (RP) Sixty Day IL - Elbow.

Chicago White Sox:  K. Teel (C) Ten Day IL - Ankle. E. Pereira (RF) Seven Day IL - Concussion. T. Gilbert (RP) Fifteen Day IL - Shoulder. A. Hays (LF) Sixty Day IL - Calf. J. Leasure (RP) Sixty Day IL - Flexor. T. Murray (LF) Sixty Day IL - Shoulder. P. Berroa (RP) Sixty Day IL - Elbow. B. Baldwin (LF) Sixty Day IL - Elbow. M. Vasil (RP) Sixty Day IL - Elbow. D. Thorpe (SP) Sixty Day IL - Elbow. K. Bush (SP) Sixty Day IL - Elbow.

“You get swept, you sweep somebody back, right? That’s a good bounceback win. That was good stuff. We bounced back very well against a good Marlins team. Beat one of the best pitchers in the game. I think our players, our team reacted very well after the way we played against Baltimore.” - Joe Espada after his team’s win against the Marlins in their game on Wednesday. 

“You've got to be able to execute pitches and continue to pound the zone, and they did that. Obviously, each one of them came out and did a great job.” - Will Venable after his team’s win against the Rangers in their game on Wednesday.

Jeremy Peña (R) SS

Yordan Alvarez (L) LF

Isaac Paredes (R) 3B

LaMonte Wade Jr. (L) RF

Yainer Diaz (R) DH

Christian Walker (R) 1B

Lucas Spence (L) CF

Nick Allen (R) 2B

Christian Vázquez (R) C

Sam Antonacci (L) LF

Munetaka Murakami (L) 1B

Miguel Vargas (R) 3B

Colson Montgomery (L) SS

Braden Montgomery (S) RF

Chase Meidroth (R) 2B

Andrew Benintendi (L) DH

Edgar Quero (S) C

Tristan Peters (L) CF

Batting Average:  Yordan Alvarez (.328)

Hits:  Yordan Alvarez (122)

Home Runs:  Yordan Alvarez (34)

RBI:  Yordan Alvarez (77)

Stolen Bases:  Cam Smith (10)

Wins:  Peter Lambert (8)

Saves:  Josh Hader (11)

ERA:  Miguel Ullola (0.00)

Batting Average:  Tristan Peters (.285)

Hits:  Chase Meidroth (101)

Home Runs:  Colson Montgomery (24)

RBI:  Miguel Vargas (61)

Stolen Bases:  Luisangel Acuña (15)

Wins:  Davis Martin (9)

Saves:  Seranthony Domínguez (12)

ERA:  Duncan Davitt (0.00)

Managers:

Houston Astros: Joe Espada (3rd season)

Chicago White Sox: Will Venable (2nd season)