Green Bay Packers vs Detroit Lions Prediction, Preview and Odds - 11/27/2025

Game Time: 1:00 pm ET, Thursday, November 27, 2025

Venue:  Ford Field, Detroit, MI 

Where to Watch:  FOX

DraftKings:  Point Spread:  Packers +2.5, Lions -2.5; Over/Under:  48.5 points

Bet365:  Point Spread:  Packers +2.5, Lions -2.5; Over/Under:  48.5 points

BetMGM:  Point Spread:  Packers +2.5, Lions -2.5; Over/Under:  49 points

Green Bay Packers:  7-3-1 (2nd place, NFC North)

Detroit Lions:  7-4 (3rd place, NFC North)

Do not miss out on our expert handicapper analysis! Al McMordie is on a HOT STREAK in the NFL on a 29-18-1 NFL RUN for +$9,280 PROFIT! Make sure you check out his picks and many more from the expert handicappers featured in the Shop Picks section.

Green Bay Packers:  won their last game at home against the Minnesota Vikings 23-6.

Detroit Lions:  won their last game at home against the New York Giants 34-27 in overtime.

The Packers are entering this game with a 7-3-1 record overall and they have a 2-0 record in their divisional games too. They are 4-2 in their home games, 3-1-1 in their road games, and they are also 0-0 in their neutral site games this season, but they will be on the road for this game. They won their last game against the Minnesota Vikings 23-6. Jordan Love was the starting QB and he completed 14/21 passes for 139 passing yards, 0 touchdowns, and 0 interceptions. Emanuel Wilson led the team in rushing yards with 107 and 2 TDs. Christian Watson led the receivers with 49 receiving yards on 5 receptions. Isaiah McDuffie led the defense in that game with 5 solo tackles and 4 assisted tackles while Devonte Wyatt and Micah Parsons each led the defense in sacks with 2. Isaiah McDuffie and Evan Williams each came away with 1 interception for them in that one.

 

 

 

The Lions are entering this game with a 7-4 record overall and they have a 1-2 record in their divisional games too. They are 4-1 in their home games, 3-3 in their road games, and they are also 0-0 in their neutral site games this season, but they will be at home for this game. They won their last game against the New York Giants 34-27 in OT. Jared Goff was the starting QB and he completed 28/42 passes for 279 passing yards, 2 touchdowns, and 1 interception. Jahmyr Gibbs led the team in rushing yards with 219 and 2 TDs. Amon-Ra St. Brown led the receivers with 149 receiving yards on 9 receptions and 1 TD. Amik Robertson led the defense in that game with 7 solo tackles and 0 assisted tackles while Aidan Hutchinson led the defense in sacks with 1. Thomas Harper came away with the only interception for them in that one.

The current betting odds have the Packers listed as a 2.5 point underdog in this game according to Draftkings Sportsbook. The Packers have looked good in their games this season with their 7-3-1 record overall which has them right near the top of the NFC North. They have also been a good road team this year with their 3-1-1 road record. Meanwhile, the Lions have looked good in their games this season with their 7-4 record overall, but that record has them right near the bottom of the NFC North in a really competitive division. They have looked great on their home field this year with their 4-1 home record. They haven't looked as good as they did last season though and they have definitely taken a step back this season. They have been up and down this year with their offense not looking great at times. Their defense has improved from last season, but still hasn't looked great at times, like in their 34-27 win over the Giants last week. They were trailing for most of that game and needed OT to win it while the Packers are off a 23-6 win over the Vikings and were cruising the entire time. The Packers have definitely had their own issues on offense this season, but they have looked a lot better lately. They also have one of the best defenses in the NFL to lean on, and that defense completely shut down the Lions in their first meeting this season. The Packers have looked like the better team lately with a defense that has been causing a lot of issues for teams, and this is a great opportunity for the Packers to spread the gap in the division. The best way to place a bet here is on the Packers to cover the spread in this game. 

Packers Lions Prediction:  Our NFL Pick for Thursday, November 27, 2025 (1:00 pm ET start time) is Packers 23 Lions 20.

Don't miss our champion handicappers free picks and expert football picks today. And if you enjoyed this Green Bay Packers Detroit Lions prediction, be sure to drop by every day for our weekly NFL predictions and previews.

Green Bay Packers: 4-7 ATS in a road game where the total is between 42.5 and 49 points. 7-13 ATS after playing a game at home. 16-8 OVER in road games. 10-4 OVER off a home win. 9-5 OVER vs. good offensive teams - scoring 24 or more points/game. 

Detroit Lions: 32-17 ATS in all games. 27-13 ATS as a favorite. 22-13 ATS against conference opponents. 29-19 OVER in all games. 16-9 OVER as a home favorite. 19-9 OVER in all games where the total is between 42.5 and 49 points.

Green Bay Packers:  J. Reed (WR) Injured - Foot. J. Jacobs (RB) Injured - Knee. N. Hobbs (CB) Injured - Knee. K. Nixon (CB) Injured - Neck. J. Love (QB) Injured - Shoulder. Z. Tom (OG) Injured - Back. Q. Walker (LB) Injured - Neck. K. Brooks (DL) Injured - Ankle. R. Doubs (WR) Injured - Wrist. D. Wicks (WR) Injured - Calf. L. Van Ness (DL) Injured - Foot. C. Watson (WR) Injured - Knee. E. Cooper (LB) Injured - Foot. J. Bullard (S) Injured - Ankle. S. Williams (WR) Injured - Foot. M. Golden (WR) Injured - Wrist.

Detroit Lions:  K. Raymond (WR) Injured - Ankle. T. Decker (OT) Injured - Shoulder. G. Glasgow (OG) Injured - Knee. M. Davenport (DL) Injured - Shoulder. J. Paschal (DL) Injured - Back. B. Wright (TE) Injured - Neck. J. Saylors (RB) Injured - Back. P. Sewell (OT) Injured - Ankle. K. Joseph (S) Injured - Knee. B. Branch (CB) Injured - Toe. T. Arnold (CB) Injured - Concussion. S. Vaki (RB) Injured - Ankle. M. Frazier (OG) Injured - Knee. I. TeSlaa (WR) Injured - Hand. T. Ratledge (OG) Injured - Knee.

“I've never called the same run so many times consecutively. It was like 3 yards and a cloud of dust, but it was effective. Bottom line, I just thought the way our defense was playing, we just took the air out of the ball and said, ‘Go win it for us.’” - Matt LaFleur after his team’s win against the Vikings in their last game. 

“We’re trying to win the game, so we want to score as many points as possible. We thought that was a place to be aggressive.” - Mike Kafka after his team’s loss against the Lions in their last game. 

WR Watson, Christian

WR Doubs, Romeo

WR Wicks, Dontayvion

TE FitzPatrick, John

QB Love, Jordan

RB Wilson, Emanuel

WR Williams, Jameson

WR St. Brown, Amon-Ra

WR Raymond, Kalif

TE Wright, Brock

QB Goff, Jared

RB Gibbs, Jahmyr

Passing: Jordan Love (2,560)

Rushing: Josh Jacobs (648)

Receiving: Romeo Doubs (522)

Touchdowns: Josh Jacobs (11)

Passing: Jared Goff (2,769)

Rushing: Jahmyr Gibbs (951)

Receiving: Amon-Ra St. Brown (884)

Touchdowns: Jahmyr Gibbs (13)

Coaches:

Green Bay Packers: Matt LaFleur (7th season)

Detroit Lions: Dan Campbell (5th season)