Florida Gators vs Mississippi Rebels Prediction, Picks and Game Preview - 11/15/2025

Game Time: 7:00 pm ET, Saturday, November 15, 2025

Venue:  Vaught Hemingway Stadium, Oxford, MS

Where to Watch:  ESPN

DraftKings:  Point Spread:  Florida +14.5, Ole Miss -14.5; Over/Under:  53.5 points

Bet365:  Point Spread:  Florida +14.5, Ole Miss -14.5; Over/Under:  53.5 points

BetMGM:  Point Spread:  Florida +14.5, Ole Miss -14.5; Over/Under:  53.5 points

Florida Gators:  3-6 (2-4) (11th place, SEC)

Mississippi Rebels:  9-1 (5-1) (4th place, SEC)

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Florida Gators:  lost their last game on the road against the Kentucky Wildcats 38-7.

Mississippi Rebels:  won their last game at home against The Citadel Bulldogs 49-0.

Florida is entering this game with a 3-6 record overall and they have a 2-4 record in their conference games too. They are 3-1 in their home games, 0-4 in their road games, and they are also 0-1 in their neutral site games this season, but they will be on the road for this game. They lost their last game against Kentucky 38-7. DJ Lagway was the starting QB and he completed 11/19 passes for 83 passing yards, 1 touchdown, and 3 interceptions. Jadan Baugh led the team in rushing yards with 64. J.Michael Sturdivant led the receivers with 29 receiving yards on 3 receptions. Sharif Denson led the defense in that game with 8 solo tackles and 0 assisted tackles while Kamran James led the defense in sacks with 1. Bryce Thornton came away with the only interception for them in that one.

 

 

 

Ole Miss is entering this game with a 9-1 record overall and they have a 5-1 record in their conference games too. They are 7-0 in their home games, 2-1 in their road games, and they are also 0-0 in their neutral site games this season, but they will be at home for this game. They won their last game against The Citadel 49-0. Trinidad Chambliss was the starting QB and he completed 29/33 passes for 333 passing yards, 3 touchdowns, and 0 interceptions. Kewan Lacy led the team in rushing yards with 49 and 3 TDs. Harrison Wallace III led the receivers with 87 receiving yards on 8 receptions. TJ Dottery led the defense in that game with 3 solo tackles and 4 assisted tackles while Talib Graham led the defense in sacks with 1. No one on the defense came away with an interception for them in that one.

The current betting odds have Ole Miss listed as a 14.5 point favorite in this game according to Draftkings Sportsbook. Ole Miss has looked great in their games this season with their 9-1 record overall and their 5-1 conference record which has them right near the top of the SEC. They have looked great on their home field too with their 7-0 home record and they are currently ranked inside the top 10. Meanwhile, Florida hasn't looked good in their games this season with their 3-6 record overall and their 2-4 conference record which has them right near the bottom of the SEC. They have been a terrible road team too with their 0-4 road record this year. Florida had a lot of hope entering the season as they were ranked inside the top 25, but their season has been a disaster. The defense has looked good at times, but the offense has looked terrible with Lagway not living up to the hype. They have already fired their head coach too. They can still become bowl eligible if they run the table, but other than that, they really have nothing left to play for this season. Ole Miss has been rolling in their games though, off a 49-0 win over The Citadel in their last one, and they have a real chance of going to the CFP. This was the game that ruined their season last year too so Ole Miss is going to bring their best effort in this one to not let that happen again. Florida is also off a 38-7 loss to Kentucky in their last one and Kentucky has one of the worst offenses in the SEC. Look for Ole Miss to continue rolling as they are focused on getting to the CFP. The best way to place a bet here is on Ole Miss to cover the spread in this game. 

Florida Mississippi Prediction:  Our NCAAF Pick for Saturday, November 15, 2025 (7:00 pm ET start time) is Ole Miss 42 Florida 17.

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Florida Gators: 2-7 ATS as a road underdog. 19-26 ATS after scoring 14 points or less last game. 15-23 ATS after 2 or more consecutive straight up losses. 25-17 UNDER in a road game where the total is between 49.5 and 56. 27-14 UNDER off a road loss against a conference rival.

Mississippi Rebels: 21-13 ATS in all lined games. 8-3 ATS when the total is between 49.5 and 56. 5-2 ATS versus poor rushing teams - averaging 120 rushing yards/game or less. 13-6 UNDER as a home favorite. 8-2 UNDER as a favorite of 10.5 to 21 points.

Florida Gators:  R. Kearney (OG) Questionable - Undisclosed. C. Banks (DL) Doubtful - Foot. J. Toombs (CB) Out - Undisclosed. D. Johnson (CB) Out - Undisclosed. J. Jackson (RB) Out - Undisclosed. M. Caraway Jr. (CB) Out - Undisclosed. A. Gates (CB) Out - Undisclosed. L. McCray (DL) Out - Undisclosed. T. Jackson (LB) Out - Undisclosed. E. Wilson III (WR) Out - Leg. D. Wilson (WR) Out - Leg. T. Spierto (WR) Questionable - Undisclosed.

Mississippi Rebels:  J. Brown (DL) Questionable - Undisclosed. J. Rush (DL) Questionable - Undisclosed. R. Collins (LB) Out - Undisclosed. A. Kite (CB) Questionable - Undisclosed.

"Obviously, it wasn't anywhere close to what we wanted. Not acceptable in any terms to take a loss the way we did, so we've got to get back, we've got to get back and look at the film and evaluate where we're at, so kind of go from there." - Billy Gonzales after his team’s loss against Kentucky in their last game. 

"I feel great about our quarterback room. I've been on record saying I think we have two quarterbacks who are better than a lot of programs' best guy. They prepare really well, get along, and I think Charlie (Weis Jr.), Joe Judge, and Fisher Ray do a really great job with them." - Lane Kiffin on his team coming into this game against Florida.

WR Wilson, Dallas

WR Sturdivant, J. Michael

WR Brown III, Vernell

TE Hansen, Hayden

QB Lagway, DJ

RB Baugh, Jadan

WR Stribling, De'Zhaun

WR Wallace III, Harrison

WR Lee, Cayden

TE Wright, Dae'Quan

QB Chambliss, Trinidad

RB Lacy, Kewan

Passing: DJ Lagway (1,762)

Rushing: Jadan Baugh (747)

Receiving: Vernell Brown III (473)

Touchdowns: Jadan Baugh (6)

Passing: Trinidad Chambliss (2,356)

Rushing: Kewan Lacy (912)

Receiving: Harrison Wallace III (579)

Touchdowns: Kewan Lacy (16)

Coaches:

Florida Gators: Billy Gonzales (Interim)

Mississippi Rebels: Lane Kiffin (6th season)