Duke Blue Devils vs Louisville Cardinals Prediction, Picks and Game Preview - 10/28/2023

Game Time: 3:30 pm ET, Saturday, October 28, 2023

Venue:  L&N Federal Credit Union Stadium, Louisville, KY

Where to Watch:  ESPN

DraftKings:  Point Spread:  Duke +4, Louisville -4; Over/Under:  46 points

Bet365:  Point Spread:  Duke +4, Louisville -4; Over/Under:  46.5 points

BetMGM:  Point Spread:  Duke +4, Louisville -4; Over/Under:  46 points

Duke Blue Devils:  5-2 (2-1) (4th place, ACC)

Louisville Cardinals:  6-1 (3-1) (3rd place, ACC)

Do not miss out on our expert handicapper analysis! Kyle Hunter is on a HOT STREAK in CFB as he is 87-46 his last 133 CFB Plays! Make sure you check out his picks and many more from the expert handicappers featured in the Shop Picks section.

Duke Blue Devils:  lost their last game on the road against the Florida State Seminoles 38-20.

Louisville Cardinals:  lost their last game on the road against the Pittsburgh Panthers 38-21.

Duke is entering this game with a 5-2 record overall and they have a 2-1 record in their conference games too. They are 4-1 in their home games, 1-1 in their road games, and they are also 0-0 in their neutral site games this season, but they will be on the road for this game. They lost their last game against Florida State 38-20. Riley Leonard was the starting QB and he completed 7/16 passes for 69 passing yards, 0 touchdowns, and 1 interception. Jaquez Moore led the team in rushing yards with 110 and 1 TD. Jordan Moore led the receivers with 26 receiving yards on 2 receptions. Al Blades Jr. led the defense in that game with 5 solo tackles and 3 assisted tackles while Wesley Williams led the defense in sacks with 1. Chandler Rivers came away with the only interception for them in that game.

 

 

 

Louisville is entering this game with a 6-1 record overall and they have a 3-1 record in their conference games too. They are 3-0 in their home games, 1-1 in their road games, and they are also 2-0 in their neutral site games this season, but they will be at home for this game. They lost their last game against Pittsburgh 38-21. Jack Plummer was the starting QB and he completed 29/52 passes for 350 passing yards, 1 touchdown, and 2 interceptions. Maurice Turner led the team in rushing yards with 81. Jamari Thrash led the receivers with 120 receiving yards on 9 receptions. Storm Duck led the defense in that game with 3 solo tackles and 3 assisted tackles while Mason Reiger led the defense in sacks with 1. No one on the defense came away with an interception for them in that game.

The current betting odds have Louisville listed as a 4 point favorite in this game according to Draftkings Sportsbook. Louisville has looked really good this season with their 6-1 record overall and their 3-1 conference record as they are starting to look like a threat in the ACC. They did lose their last game against Pitt which isn't a great loss at all but they are coming out of their bye week now and will be looking to bounce back at home here. Duke has also looked really good this season with their 5-2 record overall and they are 2-1 in conference play but they are also dealing with a banged up QB who is unlikely to play in this game. Even if Leonard does play he won't be 100% and they are going to have an angry Louisville team on their hands looking to bounce back at home. Jeff Brohm has turned things around in his 1st season coaching Louisville and they have the edge here being at home off their bye week, especially with Duke coming off a game against Florida State. The best way to place a bet here is on Louisville to cover the spread in this game. 

Duke Louisville Prediction:  Our NCAAF Pick for Saturday, October 28, 2023 (3:30 pm ET start time) is Louisville 28 Duke 17.

Don't miss our champion handicappers free picks and expert football picks today. And if you enjoyed this Duke Blue Devils Louisville Cardinals prediction, be sure to drop by every day for our weekly NCAAF predictions and previews.

Duke Blue Devils: 23-15 ATS as a road underdog of 7 points or less. 14-5 ATS after 3 consecutive games where they forced 1 or less turnovers. 12-7 UNDER in a road game where the total is between 45.5 and 49. 

Louisville Cardinals: 3-14 ATS in a home game where the total is between 45.5 and 49. 12-20 ATS after allowing 125 or less rushing yards in 3 straight games. 22-9 UNDER as a home favorite of 7 points or less. 11-6 UNDER in a home game where the total is between 45.5 and 49. 

Duke Blue Devils:  N. Dalmolin (TE) Ques Sat - Undisclosed. R. Leonard (QB) Ques Sat - Ankle. E. Pancol (WR) Out indefinitely - Lower Body.

Louisville Cardinals:  R. Brown (OL) out for season - Undisclosed. J. Jordan (RB) Ques Sat - Hamstring. M. Griffin (DB) out for season - Leg.

“He was begging me on the sideline to come back in. I didn't feel comfortable with where he was health-wise to move back, so we didn't do it.” - Mike Elko on Riley Leonard after his team’s loss against FSU in their last game. 

“Winning the turnover battle is vital to success. You saw it in the Notre Dame game, it definitely helped us. Of course, in the Pittsburgh game, it hurt us that we turned the ball over so much, especially when you play the game where you have twice as many first downs as the other team. Turnovers were crucial. It really, really hurt us, so that was unfortunate.” - Jeff Brohm on his team’s upcoming game against Duke this week.

WR Hagans, Sahmir  

WR Moore, Jordan

WR Calhoun, Jalon 

TE Dalmolin, Nicky 

QB Leonard, Riley 

RB Coleman, Jaylen

WR Thrash, Jamari 

WR Calloway, Jimmy  

WR Coleman, Kevin 

TE Lifson, Josh 

QB Plummer, Jack 

RB Jordan, Jawhar 

Passing: R. Leonard (981)

Rushing: J. Waters (465)

Receiving: J. Calhoun (379)

Touchdowns: J. Waters (9)

Passing: J. Plummer (1901)

Rushing: J. Jordan (661)

Receiving: J. Thrash (639)

Touchdowns: J. Jordan (9)

Coaches:

Duke Blue Devils: Mike Elko (2nd season)

Louisville Cardinals: Jeff Brohm (1st season)