Detroit Tigers vs Cleveland Guardians Prediction, Preview and Odds - 07/05/2025

Game Time: 7:15 pm ET, Saturday, July 5, 2025

Venue:  Progressive Field, Cleveland, OH

Where to Watch:  FOX

DraftKings:  Moneyline odds:  Tigers -144, Guardians +118; Over/Under:  8.5 runs

Bet365:  Moneyline odds:  Tigers -140, Guardians +120; Over/Under:  8.5 runs

BetMGM:  Moneyline odds:  Tigers -145, Guardians +120; Over/Under:  8.5 runs

Detroit Tigers:  54-34 (1st place, AL Central)

Cleveland Guardians:  40-45 (3rd place, AL Central)

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Detroit Tigers:  6-4 last 10

Cleveland Guardians:  2-8 last 10

The Tigers are entering this series off a loss and lost their 3-game series against the Washington Nationals 2-1 in their last series. They enter this game with a 54-34 record overall and have a road record of 24-20. This is the 2nd game of a 3-game series with the Guardians on Saturday with the series opener still to be played on Friday. Their offense ranks 5th in the MLB with a .753 OPS. Reese Olson is their starting pitcher on Friday while Casey Mize is making his start in this game on Saturday. He is 8-2 with a 2.86 ERA this season. His team won their last 3 straight games this season with him making an appearance. In his last MLB regular season start, he allowed 2 ER, 1 HR, and 1 BB with 5 SO on 5 hits through 6.2 IP against the Minnesota Twins.

The Guardians are entering this series off a loss and got swept in their 3-game series against the Chicago Cubs 3-0 in their last series. They enter this game with a 40-45 record overall and have a home record of 20-20. This is the 2nd game of a 3-game series with the Tigers on Saturday with the 1st game of this series still to be played on Friday. Their offense ranks 27th in the MLB with a .660 OPS. Slade Cecconi is their starting pitcher on Friday while Logan Allen is making his start in this game on Saturday. He is 5-6 with a 4.27 ERA this season. His team lost their last 2 straight games this season with him making an appearance. In his last MLB regular season start, he allowed 3 earned runs, 1 homer, and 2 walks with 6 strikeouts on 6 hits through 6 innings pitched against the St Louis Cardinals.

The current betting odds have the Tigers listed as a favorite in this game according to Draftkings Sportsbook. The Tigers have looked great in their games this season with their 54-34 record overall which has them right at the top of the AL Central with one of the best records in the entire MLB. They have also been a good road team with their 24-20 road record this season. Meanwhile, the Guardians haven't looked good in their games this season with their 40-45 record overall which has them right near the top of the AL Central but not in the division race. They haven't even looked great in their own ballpark with their 20-20 home record this season. The Guardians have also looked terrible lately as they are 2-8 in their last 10 games and have one of the worst offenses in the MLB. The Tigers are 6-4 in their last 10 games with one of the best offenses in the MLB and they have the better pitching matchup in this one too. Mize is on the mound for the Tigers in this one and he has looked great this year. He is 8-2 with a 2.86 ERA and hasn't been giving up many runs all year. He is coming off another great start in which he only gave up 2 earned runs and the team has won 3 games in a row with him starting too. Allen is on the mound for the Guardians in this one and he hasn't looked great this year. He is 5-6 with a 4.27 ERA and the team has lost 2 games in a row now with him starting. He also gave up 3 earned runs in his last start which has been a common theme for him this year and he will get himself into trouble against this Tigers offense, especially with his team in a big slump right now. The best way to place a bet here is on the Tigers to win this game. 

Tigers Guardians Prediction:  Our MLB Pick for Saturday, July 5, 2025 (7:15 pm ET start time) is Tigers 5 Guardians 1.

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Detroit Tigers: 222-198 (+37.4 units) on the moneyline in all games. 111-101 (+30.1 units) on the moneyline in road games. 80-53 (+28 units) on the moneyline against division opponents. 

Cleveland Guardians: 212-206 (-8.5 units) on the moneyline in all games. 97-114 (-10.8 units) on the moneyline when playing against a team with a winning record. 53-73 (-13.8 units) on the moneyline vs. teams outscoring opp by 0.5 or more runs/game on the season. 

Detroit Tigers:  S. Gipson-Long (SP) Fifteen Day IL - Neck. K. Carpenter (RF) Ten Day IL - Hamstring. J. Jobe (SP) Sixty Day IL - Flexor. J. Foley (RP) Sixty Day IL - Shoulder. A. Cobb (SP) Sixty Day IL - Hip. R. Olson (SP) Fifteen Day IL - Finger. T. Madden (SP) Sixty Day IL - Shoulder. J. Urquidy (SP) Sixty Day IL - Elbow. A. Lange (RP) Sixty Day IL - Lat.

Cleveland Guardians:  G. Arias (SS) Ten Day IL - Ankle. W. Brennan (RF) Sixty Day IL - Forearm. A. Walters (RP) Sixty Day IL - Lat. B. Lively (SP) Sixty Day IL - Forearm. P. Sewald (RP) Fifteen Day IL - Shoulder. S. Bieber (SP) Sixty Day IL - Elbow. T. Stephan (RP) Sixty Day IL - Elbow. J. Means (SP) Sixty Day IL - Elbow. S. Hentges (RP) Sixty Day IL - Shoulder.

"We expected [Torres] to be a starting All-Star second baseman for the American League. We knew it all the way. But seriously, we did feel like we were getting a good player at a good time to be able to get good performance out of him. The way it's played out is obviously special for him, and it's special for us, because he bet on himself [and] came on a one-year deal to a young team as a veteran presence. We had to move some people around to accommodate that. Both parties worked hard to establish this relationship to where he trusted us, and we felt like we were going to get something by giving him the opportunity.” - A.J. Hinch after his team’s loss against the Nationals in their game on Thursday.

“Joey was great. Joey was pounding the strike zone. [He had] a couple of walks, but he worked around them. It was really good to see him back out there. He gave us what he had.” - Stephen Vogt after his team’s loss against the Cubs in their game on Thursday.

Colt Keith (L) 1B

Gleyber Torres (R) 2B

Wenceel Pérez (S) RF

Riley Greene (L) LF

Spencer Torkelson (R) DH

Zach McKinstry (L) 3B

Dillon Dingler (R) C

Parker Meadows (L) CF

Javier Báez (R) SS

Steven Kwan (L) LF

Kyle Manzardo (L) DH

José Ramírez (S) 3B

Carlos Santana (S) 1B

Lane Thomas (R) CF

Nolan Jones (L) RF

Daniel Schneemann (L) 2B

Bo Naylor (L) C

Brayan Rocchio (S) SS

Batting Average:  Brewer Hicklen (.667)

Hits:  Riley Greene (97)

Home Runs:  Riley Greene (21)

RBI:  Riley Greene (69)

Stolen Bases:  Zach McKinstry (10)

Wins:  Tarik Skubal (10)

Saves:  Will Vest (13)

ERA:  Matt Gage (0.00)

Batting Average:  José Ramírez (.297)

Hits:  Steven Kwan (94)

Home Runs:  José Ramírez (13)

RBI:  José Ramírez (38)

Stolen Bases:  José Ramírez (21)

Wins:  Gavin Williams (5)

Saves:  Emmanuel Clase (18)

ERA:  Nic Enright (2.08)

Managers:

Detroit Tigers: A.J. Hinch (5th season)

Cleveland Guardians: Stephen Vogt (2nd season)