Detroit Pistons vs New York Knicks Prediction, Preview and Odds - 04/21/2025

Game Time: 7:30 pm ET, Monday, April 21, 2025

Venue:  Madison Square Garden, New York, NY 

Where to Watch:  TNT, MAX, truTV

DraftKings:  Point Spread:  Pistons +6.5, Knicks -6.5; Over/Under:  222 points

Bet365:  Point Spread:  Pistons +6.5, Knicks -6.5; Over/Under:  222 points

BetMGM:  Point Spread:  Pistons +6.5, Knicks -6.5; Over/Under:  221.5 points

Detroit Pistons:  44-38 (4th place, Central Division)

New York Knicks:  51-31 (2nd place, Atlantic Division)

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Detroit Pistons:  3-7 last 10

New York Knicks:  6-4 last 10

The Pistons are entering the playoffs with a 44-38 record overall this season and they were 22-19 in their road games where they will be in this game. They are entering this game on a 3 game losing streak with losses coming against the Milwaukee Bucks twice in a row and the New York Knicks. Tobias Harris led the team in points in that game with 25 while Cade Cunningham was next on the team with 21 points. Cade Cunningham led the team in assists in that game with 12 while Cade Cunningham, Jalen Duren, Ausar Thompson, and Tobias Harris each led the team in rebounds with 6. They were 47.7% from the field, 46.9% from 3-point range, and 75% from the free throw line with their shots in that game. Their offense is averaging 115.5 PPG and their defense is allowing their opponents to average 113.6 PPG against them. The Pistons have an ATS record of 42-38-3 this season and their O/U record is 42-39-2.

The Knicks are entering the playoffs with a 51-31 record overall this season and they were 27-14 in their home games where they will be in this game. They are entering this game on a 2 game winning streak with wins coming against the Brooklyn Nets and the Detroit Pistons. Jalen Brunson led the team in points in that game with 34 while OG Anunoby and Karl-Anthony Towns each were next on the team with 23 points. Jalen Brunson led the team in assists in that game with 8 while Karl-Anthony Towns led the team in rebounds with 11. They were 52.7% from the field, 38.5% from 3-point range, and 88.2% from the free throw line with their shots in that game. Their offense is averaging 115.8 PPG and their defense is allowing their opponents to average 111.7 PPG against them. The Knicks have an ATS record of 41-41-1 this season and their O/U record is 43-39-1.

The current betting odds have the Knicks listed as a 6.5 point favorite in this game according to Draftkings Sportsbook. This is game 2 of a 7 game series between the 3rd seeded Knicks and the 6th seeded Pistons from the Eastern Conference for the 1st round of the NBA playoffs. The Knicks are leading this series 1-0 after game 1. The Knicks took the 1st game in this series 123-112 and they have been a solid home team all season. The Pistons were able to hang in that game all night, even taking a big lead in the 3rd quarter, but the Knicks got their act together in the 4th quarter and dominated the Pistons to end up winning by double digits. The Pistons had a great season considering where they finished last season, but they are still a young team that doesn't have a lot of experience and it showed in that 1st game when they had the late lead. The Knicks got off to a slow start in that one, but they were also missing a lot of key players down the final stretch of the season so they needed some time to settle into the game. Now they will be ready to go right out of the gate and they will be looking to take a 2-0 series lead in what should be an easier series for them. Look for the Knicks to come out much stronger in this game right from the start and take advantage of a young and inexperienced playoff team on the road. The best way to place a bet here is on the Knicks to cover the spread in this game. 

Pistons Knicks Prediction:  Our NBA Pick for Monday, April 21, 2025 (7:30 pm ET start time) is Knicks 126 Pistons 113.

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Detroit Pistons: 14-5 ATS against Atlantic division opponents. 19-10 ATS as an underdog  of 3.5 to 9.5 points. 12-4 ATS after 2 or more consecutive losses. 22-16 OVER when the total is 220 to 229.5. 26-18 OVER versus good shooting teams - making 46% of their shots or more.

New York Knicks: 4-8 ATS at home when playing against a marginal winning team (Win Pct. 51% to 60%). 7-13 1H ATS as a home favorite of 6.5 to 12 points. 8-14 1H ATS when playing only their 2nd game in 5 days. 24-16 OVER after playing a home game. 11-6 OVER when playing 4 or less games in 10 days.

Detroit Pistons:  I. Stewart (C) Day To Day - Knee. J. Ivey (SG) Out - Leg.

New York Knicks:  None.

“Obviously, for this group, guys having first-time playoff experience, just understanding yeah, it stinks to lose, but it’s all about how you come back.” - Tobias Harris after their loss against the Knicks in game 1 of this series.

“Obviously, we didn’t end the third quarter the way we wanted to, but there was never a doubt that we’re going to just lay down and not fight. We had to find a way to figure things out and keep battling and I mean, it turned around quickly.” - Jalen Brunson after their win against the Pistons in game 1 of this series.

PG Cade Cunningham

SG Tim Hardaway Jr.

SF Ausar Thompson

PF Tobias Harris

C Jalen Duren

PG Jalen Brunson

SG Mikal Bridges

SF Josh Hart

PF OG Anunoby

C Karl-Anthony Towns

PPG: C. Cunningham (26.1)

APG: C. Cunningham (9.1)

Reb/G: J. Duren (10.3)

PPG: J. Brunson (26)

APG: J. Brunson (7.3)

Reb/G: K. Towns (12.8)

Coaches:

Detroit Pistons: J.B. Bickerstaff (1st season)

New York Knicks: Tom Thibodeau (5th season)