Detroit Pistons vs Milwaukee Bucks Prediction, Preview and Odds - 11/22/2025

Game Time: 8:00 pm ET, Saturday, November 22, 2025

Venue:  Fiserv Forum, Milwaukee, WI

Where to Watch:  NBA TV

DraftKings:  Point Spread:  Pistons -8, Bucks +8; Over/Under:  224.5 points

Bet365:  Point Spread:  Pistons -8, Bucks +8; Over/Under:  224.5 points

BetMGM:  Point Spread:  Pistons -8, Bucks +8; Over/Under:  224.5 points

Detroit Pistons:  13-2 (1st place, Central Division)

Milwaukee Bucks:  8-8 (4th place, Central Division)

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Detroit Pistons:  10-0 last 10

Milwaukee Bucks:  4-6 last 10

The Pistons are entering this game with a 13-2 record overall this season and they are 5-1 in their road games this season where they will be in this game. They are entering this game on an 11 game winning streak with wins coming against the Orlando Magic, the Dallas Mavericks, the Memphis Grizzlies, the Utah Jazz, the Brooklyn Nets, the Philadelphia 76ers, the Washington Wizards, the Chicago Bulls, the 76ers again, the Indiana Pacers, and the Atlanta Hawks. Cade Cunningham led the team in points in that game with 25 while Jalen Duren was next on the team with 24 points. Cade Cunningham led the team in assists in that game with 10 while Isaiah Stewart led the team in rebounds with 9. They were 54.2% from the field, 32.3% from 3-point range, and 83.3% from the free throw line with their shots in that game. Their offense is averaging 118.9 PPG and their defense is allowing their opponents to average 112.1 PPG against them. The Pistons have an ATS record of 11-4 this season and their O/U record is 8-6-1.

The Bucks are entering this game with an 8-8 record overall this season and they are 5-4 in their home games this season where they will be in this game. They are entering this game on a 3 game losing streak with losses coming against the Los Angeles Lakers, the Cleveland Cavaliers, and the Philadelphia 76ers. Ryan Rollins led the team in points in that game with 32 while Bobby Portis was next on the team with 19 points. Ryan Rollins led the team in assists in that game with 14 while Myles Turner led the team in rebounds with 10. They were 48.9% from the field, 38.9% from 3-point range, and 76.9% from the free throw line with their shots in that game. Their offense is averaging 117.4 PPG and their defense is allowing their opponents to average 119 PPG against them. The Bucks have an ATS record of 7-9 this season and their O/U record is 9-7.

The current betting odds have the Pistons listed as an 8 point favorite in this game according to Draftkings Sportsbook. The Pistons have looked great in their games this season with their 13-2 record overall which has them right at the top of the East with one of the best records in the entire NBA. They have also been a great road team this year with their 5-1 road record. Meanwhile, the Bucks haven't looked great in their games this season with their 8-8 record overall which has them lower in the East at the moment. They haven't looked that great on their home court either with their 5-4 home record this season. They have been dealing with some injuries now, missing Giannis Antetokounmpo, and they haven't looked as good without him in the lineup. They are off a loss in OT to the 76ers in their last one and they have lost 3 games in a row now too. The Pistons have been rolling in their games lately with 11 wins in a row now and they have been blowing out a lot of teams during that time. They managed to get by with injuries as they have a really deep team, but now they are getting healthy again and have looked even better. The Pistons are also more rested here, having last played on Tuesday, so look for them to take advantage of a Bucks team missing their best player. The best way to place a bet here is on the Pistons to cover the spread in this game. 

Pistons Bucks Prediction:  Our NBA Pick for Saturday, November 22, 2025 (8:00 pm ET start time) is Pistons 121 Bucks 109.

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Detroit Pistons: 11-4 ATS in all games. 8-3 ATS versus good passing teams, averaging 23 assists/game or more. 7-3 ATS versus poor defensive teams - allowing 116+ points/game. 19-13 OVER vs. poor rebounding teams - outrebounded by opponents by 3+ per game.

Milwaukee Bucks: 2-6 ATS after playing a home game. 3-6 ATS versus good offensive teams - scoring 116+ points/game. 3-8 ATS versus good passing teams, averaging 23 assists/game or more. 7-2 OVER in home games.

Detroit Pistons:  C. LeVert (SG) Day To Day - Ankle. B. Klintman (SF) Day To Day - Ankle. T. Harris (PF) Day To Day - Ankle. M. Sasser (PG) Out - Hip. J. Ivey (SG) Out - Knee.

Milwaukee Bucks:  G. Antetokounmpo (PF) Out - Groin. T. Prince (SF) Out - Neck. K. Porter Jr. (SG) Out - Ankle.

“I mean that's what superstars do, and Cade is in that air of superstars. He thrives in that moment. But I thought we had a bunch of guys down the stretch who have been proving that they can make plays for us.” - J.B. Bickerstaff after his team’s win against the Hawks in their game on Tuesday.

“We played hard overall, but our execution at times tonight – and I get it, we have different guys – but some of (the plays), we just have to do it.” - Doc Rivers after his team’s loss against the 76ers in their game on Thursday.

PG Cade Cunningham

SG Duncan Robinson

SF Ausar Thompson

PF Isaiah Stewart

C Jalen Duren 

PG Ryan Rollins

SG AJ Green

SF Kyle Kuzma

PF Bobby Portis

C Myles Turner

PPG: Cade Cunningham (27.3)

APG: Cade Cunningham (9.9)

Reb/G: Jalen Duren (11.9)

PPG: Giannis Antetokounmpo (31.2)

APG: Giannis Antetokounmpo (6.8)

Reb/G: Giannis Antetokounmpo (10.8)

Coaches:

Detroit Pistons: J.B. Bickerstaff (2nd season)

Milwaukee Bucks: Doc Rivers (3rd season)