Detroit Lions vs Arizona Cardinals Prediction, Preview and Odds - 10/11/2026

Game Time: 4:25 pm ET, Sunday, October 11, 2026

Venue:  State Farm Stadium, Glendale, AZ

Where to Watch:  FOX

DraftKings:  Point Spread:  Lions -5.5, Cardinals +5.5; Over/Under:  54.5 points

Bet365:  Point Spread:  Lions -5.5, Cardinals +5.5; Over/Under:  54.5 points

BetMGM:  Point Spread:  Lions -5.5, Cardinals +5.5; Over/Under:  54.5 points

Detroit Lions:  2-2 (3rd place, NFC North)

Arizona Cardinals:  1-3 (4th place, NFC West)

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Detroit Lions:  lost their last game on the road against the Carolina Panthers 32-26.

Arizona Cardinals:  lost their last game on the road against the New York Giants 36-24.

The Lions are entering this game with a 2-2 record overall and they have a 0-2 record in their divisional games too. They are 2-0 in their home games, 0-2 in their road games, and they are also 0-0 in their neutral site games this season, but they will be on the road for this game. They lost their last game against the Carolina Panthers 32-26. Jared Goff was the starting QB and he completed 32/52 passes for 412 passing yards, 1 touchdown, and 0 interceptions. Jahmyr Gibbs led the team in rushing yards with 46 and 1 TD. Jameson Williams led the receivers with 102 receiving yards on 6 receptions. Jack Campbell led the defense in that game with 13 solo tackles while Christian Izien, Alim McNeill, and D.J. Wonnum each led the defense in sacks with 1. No one on the defense came away with an interception for them in that one.

 

 

 

The Cardinals are entering this game with a 1-3 record overall and they have a 0-2 record in their divisional games too. They are 0-1 in their home games, 1-2 in their road games, and they are also 0-0 in their neutral site games this season, but they will be at home for this game. They lost their last game against the New York Giants 36-24. Jacoby Brissett was the starting QB and he completed 21/35 passes for 166 passing yards, 2 touchdowns, and 3 interceptions. Jeremiyah Love led the team in rushing yards with 63. Michael Wilson led the receivers with 95 receiving yards on 7 receptions. Jack Gibbens led the defense in that game with 8 solo tackles while Darius Robinson, Walter Nolen, Josh Sweat, and Zaven Collins each led the defense in sacks with 1. Budda Baker and Denzel Burke each came away with 1 interception for them in that one.

The current betting odds have the Lions listed as a 5.5 point favorite in this game according to Draftkings Sportsbook. The Lions haven't looked great in their games this season with their 2-2 record overall which has them right near the bottom of the NFC North. They haven't been a good road team either with their 0-2 road record this year. Meanwhile, the Cardinals haven't looked good in their games this season with their 1-3 record overall which has them right at the bottom of the NFC West. They haven't looked great on their home field either with their 0-1 home record this season. The Cardinals were expected to be one of the worst teams in the NFL this season and even though they aren't one of the winless teams after the first month of the season, they still might be one of the worst teams. They looked like they were going to turn things around quickly with an upset win over the Chargers right out of the gate, but that win looks a lot more cute now with the Chargers still being winless. The Cardinals have now lost 3 games in a row since that 1st win and they are coming off a 36-24 loss to the Giants in their last one, blowing that game in embarrassing fashion. The Lions haven't had the best start to their season, but they are a more talented team that has been in the playoff conversation for a few years now and this is going to be a nice game for them to get right. They are coming off a 32-26 loss to the Panthers, but their offense still looked good and they have been putting up a ton of points all season. Their defense has still looked terrible, but this Cardinals offense isn't going to be much of a challenge with how bad Brissett has been and they won't be able to keep up with this Lions offense even if they play well. The best way to place a bet here is on the Lions to cover the spread in this game. 

Lions Cardinals Prediction:  Our NFL Pick for Sunday, October 11, 2026 (4:25 pm ET start time) is Lions 35 Cardinals 24.

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Detroit Lions: 8-3 ATS as a road favorite. 7-3 ATS after 1 or more consecutive losses. 8-2 ATS vs. bad defensive teams who give up 24 or more points/game. 24-14 OVER in all games. 15-8 OVER in all games where the total is greater than or equal to 49.5.

Arizona Cardinals: 4-7 ATS as a home underdog. 3-7 ATS in a home game where the total is greater than or equal to 45.5. 2-5 ATS versus poor defensive teams - allowing 350 yards/game or more. 7-3 OVER in a home game where the total is greater than or equal to 45.5. 9-4 OVER after allowing 30 points or more last game.

Detroit Lions:  R. Ya-Sin (CB) Injured - Hamstring. D. Wonnum (DL) Injured - Back. C. Mays (C) Injured - Wrist. B. Bartch (OG) Injured - Foot. B. Branch (CB) Injured - Achilles. T. Williams (DL) Injured - Foot.

Arizona Cardinals:  W. Nolen III (DL) Injured - Calf. K. Sharar (LB) Injured - Hamstring. I. Adams (OG) Injured - Ankle. B. Baker (S) Injured - Rest. J. Burch (LB) Injured - Personal. I. Seumalo (OG) Injured - Rest. J. Sweat (LB) Injured - Rest. A. Wingard (S) Injured - Knee. J. Love (RB) Injured - Ankle. D. Taylor-Demerson (S) Injured - Back.

“We got ourselves in a hole there, which is frustrating. At the end of the day, we had our opportunities. Our defense came up with a stop and we had the ball with about with two minutes left to go win the game. And we just couldn’t get it done.” - Dan Campbell after his team’s loss against the Panthers in their last game. 

“All three loses we’ve had over the last three weeks have been different. This one is going to sting. It's not going to be the most fun ride home. There are certainly things I know I could have done better. We have to get right back to work because no one is going to feel sorry for us.” - Mike LaFleur after his team’s loss against the Giants in their last game. 

WR TeSlaa, Isaac

WR Williams, Jameson

WR St. Brown, Amon-Ra

TE LaPorta, Sam

QB Goff, Jared

RB Gibbs, Jahmyr

WR Harrison Jr., Marvin

WR Wilson, Michael

WR Bourne, Kendrick

TE McBride, Trey

QB Brissett, Jacoby

RB Love, Jeremiyah

Passing: Jared Goff (1,214)

Rushing: Jahmyr Gibbs (353)

Receiving: Amon-Ra St. Brown (303)

Touchdowns: Jahmyr Gibbs (7)

Passing: Jacoby Brissett (818)

Rushing: Jeremiyah Love (223)

Receiving: Michael Wilson (258)

Touchdowns: Trey McBride (2)

Coaches:

Detroit Lions: Dan Campbell (6th season)

Arizona Cardinals: Mike LaFleur (1st season)