Denver Nuggets vs Houston Rockets Prediction, Preview and Odds - 11/21/2025

Game Time: 9:30 pm ET, Friday, November 21, 2025

Venue:  Toyota Center, Houston, TX 

Where to Watch:  Prime Video

DraftKings:  Point Spread:  Nuggets +2.5, Rockets -2.5; Over/Under:  233.5 points

Bet365:  Point Spread:  Nuggets +2.5, Rockets -2.5; Over/Under:  233.5 points

BetMGM:  Point Spread:  Nuggets +1.5, Rockets -1.5; Over/Under:  233.5 points

Denver Nuggets:  11-3 (2nd place, Northwest Division)

Houston Rockets:  10-3 (1st place, Southwest Division)

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Denver Nuggets:  8-2 last 10

Houston Rockets:  9-1 last 10

The Nuggets are entering this game with an 11-3 record overall this season and they are 5-2 in their road games this season where they will be in this game. They are entering this game off a win against the New Orleans Pelicans. Peyton Watson led the team in points in that game with 32 while Nikola Jokić was next on the team with 28 points. Nikola Jokić led the team in assists in that game with 12 while Peyton Watson led the team in rebounds with 12. They were 55.4% from the field, 35.5% from 3-point range, and 81.5% from the free throw line with their shots in that game. Their offense is averaging 124.6 PPG and their defense is allowing their opponents to average 113.1 PPG against them. The Nuggets have an ATS record of 9-5 this season and their O/U record is 8-6.

The Rockets are entering this game with a 10-3 record overall this season and they are 5-1 in their home games this season where they will be in this game. They are entering this game on a 5 game winning streak with wins coming against the Milwaukee Bucks, the Washington Wizards, the Portland Trail Blazers, the Orlando Magic, and the Cleveland Cavaliers. Alperen Şengün led the team in points in that game with 28 while Kevin Durant was next on the team with 20 points. Alperen Şengün led the team in assists in that game with 7 while Alperen Şengün and Steven Adams each led the team in rebounds with 11. They were 45.6% from the field, 37.5% from 3-point range, and 85.2% from the free throw line with their shots in that game. Their offense is averaging 123.9 PPG and their defense is allowing their opponents to average 112.5 PPG against them. The Rockets have an ATS record of 9-4 this season and their O/U record is 10-2-1.

The current betting odds have the Rockets listed as a 2.5 point favorite in this game according to Draftkings Sportsbook. The Rockets have looked great in their games this season with their 10-3 record overall which has them right near the top of the West. They have looked great on their home court too with their 5-1 home record this season. Meanwhile, the Nuggets have looked great in their games this season with their 11-3 record overall which has them right near the top of the West. They have been a good road team this year too with their 5-2 road record. The Nuggets are off a win over the Pelicans in their last one and they have been putting up a ton of points this year with one of the best offenses in the NBA. Scoring was a big issue for the Rockets last season as their defense carried the team in a lot of their games, but their offense has looked a lot better this year. They also have one of the best offenses in the NBA, right behind the Nuggets, and their defense has also been great. Both of these teams are 1-1 in their group for the NBA Cup so this is a big game for both sides. The Nuggets bounced back in their last game with a win over the Pelicans, but the Rockets have been rolling in their games lately. The Rockets have a ton of momentum on their side with 5 wins in a row now and the home advantage should give them the edge in this one. The best way to place a bet here is on the Rockets to cover the spread in this game. 

Nuggets Rockets Prediction:  Our NBA Pick for Friday, November 21, 2025 (9:30 pm ET start time) is Rockets 114 Nuggets 108.

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Denver Nuggets: 9-5 ATS in all games. 4-1 ATS when playing against a team with a winning record. 6-2 ATS versus good shooting teams - making 46% of their shots or more. 20-13 OVER as a road underdog. 25-18 OVER versus teams who average 9 or more steals/game on the season.

Houston Rockets: 1-4 ATS versus good foul drawing teams - attempting 27 free throws/game or more. 26-13 OVER against Northwest division opponents. 15-8 OVER versus good rebounding teams - outrebounding opponents by 3+ per game.

Denver Nuggets:  A. Gordon (PF) Day To Day - Hamstring. J. Strawther (SG) Day To Day - Back. C. Braun (SG) Out - Ankle.

Houston Rockets:  D. Finney-Smith (PF) Out - Ankle. T. Eason (PF) Out - Oblique. F. VanVleet (PG) Out For Season - ACL.

"The whole team as a collective, we have to take care of the ball better." - David Adelman after his team’s win against the Pelicans in their game on Wednesday.

"He’s a guy that may not play, but is ready to come in and impact the game. When Tari gets hurt in that game or when he knows he’s playing a more expanded role, he’s been great. We give him his props after those games when he does that. He’s just a guy that you love to have on your team, for those reasons.” - Ime Udoka on Aaron Holiday this season.

PG Jamal Murray

SG Cameron Johnson

SF Peyton Watson

PF Aaron Gordon

C Nikola Jokic

PG Amen Thompson

SG Josh Okogie

SF Kevin Durant

PF Jabari Smith Jr.

C Alperen Sengun

PPG: Nikola Jokic (29.1)

APG: Nikola Jokic (11.1)

Reb/G: Nikola Jokic (13.2)

PPG: Kevin Durant (25.5)

APG: Alperen Sengun (7.4)

Reb/G: Alperen Sengun (10.4)

Coaches:

Denver Nuggets: David Adelman (2nd season)

Houston Rockets: Ime Udoka (3rd season)