Denver Broncos vs Arizona Cardinals Prediction, Preview and Odds - 10/25/2026

Game Time: 4:05 pm ET, Sunday, October 25, 2026

Venue:  State Farm Stadium, Glendale, AZ 

Where to Watch:  CBS

DraftKings:  Point Spread:  Broncos -4.5, Cardinals +4.5; Over/Under:  43.5 points

Bet365:  Point Spread:  Broncos -4.5, Cardinals +4.5; Over/Under:  43.5 points

BetMGM:  Point Spread:  Broncos -4.5, Cardinals +4.5; Over/Under:  43.5 points

Denver Broncos:  4-2 (2nd place, AFC West)

Arizona Cardinals:  2-4 (3rd place, NFC West)

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Denver Broncos:  won their last game at home against the Seattle Seahawks 17-14 in overtime. 

Arizona Cardinals:  won their last game on the road against the Los Angeles Rams 18-16.

The Broncos are entering this game with a 4-2 record overall and they have a 1-1 record in their divisional games too. They are 3-0 in their home games, 1-2 in their road games, and they are also 0-0 in their neutral site games this season, but they will be on the road for this game. They won their last game against the Seattle Seahawks 17-14 in OT. Bo Nix was the starting QB and he completed 17/27 passes for 107 passing yards, 0 touchdowns, and 0 interceptions. J.K. Dobbins led the team in rushing yards with 41 and 1 TD. RJ Harvey led the receivers with 31 receiving yards on 3 receptions. Alex Singleton led the defense in that game with 13 solo tackles while Ja'Quan McMillian, Quandarrius Robinson, and Jonah Elliss each led the defense in sacks with 1. Kris Abrams-Draine and Ja'Quan McMillian each came away with 1 interception for them in that one.

 

 

 

The Cardinals are entering this game with a 2-4 record overall and they have a 1-2 record in their divisional games too. They are 0-2 in their home games, 2-2 in their road games, and they are also 0-0 in their neutral site games this season, but they will be at home for this game. They won their last game against the Los Angeles Rams 18-16. Jacoby Brissett was the starting QB and he completed 24/35 passes for 218 passing yards, 0 touchdowns, and 1 interception. Zonovan Knight led the team in rushing yards with 80. Trey McBride led the receivers with 53 receiving yards on 7 receptions. Mack Wilson Sr. led the defense in that game with 9 solo tackles while Budda Baker and Josh Sweat each led the defense in sacks with 1. No one on the defense came away with an interception for them in that one.

The current betting odds have the Cardinals listed as a 4.5 point underdog in this game according to Draftkings Sportsbook. The Cardinals haven't looked good in their games this season with their 2-4 record overall which has them right near the bottom of the NFC West. They have looked terrible on their home field too with their 0-2 home record this season. Meanwhile, the Broncos have looked good in their games this season with their 4-2 record overall which has them right near the top of the AFC West. They haven't been a great road team though with their 1-2 road record this year. The Broncos had one of the best defenses in the NFL last season and they look like they have a great defense again, but they have some major issues on offense and that has caused them to be really up and down all year. They are coming off a 17-14 win over the Seahawks in their last one, but their offense once again looked terrible in that game and Bo Nix just hasn't looked right this season. That defense is going to keep them in a lot of games this year, but the offense is an issue and they haven't really been blowing many teams out in their wins. The Cardinals were supposed to be one of the worst teams in the NFL this season and they have looked like it in their 4 games after upsetting the Chargers in week 1. They are coming off an 18-16 road win over the Rams in their last one though and they have proven themselves to be a scrappy team at times. They have looked terrible at home this season, but they are going to have some momentum from that win over the Rams and they can keep this a tighter game with how bad that Broncos offense has looked all season. The best way to place a bet here is on the Broncos to cover the spread in this game. 

Broncos Cardinals Prediction:  Our NFL Pick for Sunday, October 25, 2026 (4:05 pm ET start time) is Broncos 20 Cardinals 17.

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Denver Broncos: 10-3 ATS in non-conference games. 10-5 ATS after allowing 14 points or less last game. 6-3 ATS vs. poor passing defenses - allowing 7 or more passing yards/att. 11-4 OVER vs. bad defensive teams who give up 24 or more points/game. 9-2 OVER versus poor defensive teams - allowing 5.65 yards/play or more. 

Arizona Cardinals: 4-8 ATS as a home underdog. 4-8 ATS after playing a division game. 3-10 ATS when playing against a good team (Win Pct. 60% to 75%). 10-5 OVER in a home game where the total is between 42.5 and 49 points. 9-3 OVER when playing against a good team (Win Pct. 60% to 75%).

Denver Broncos:  J. Waddle (WR) Injured - Chest. T. Badie (RB) Injured - Thumb. T. Hufanga (S) Injured - Ankle. J. Elliss (LB) Injured - Ankle. J. Coleman (RB) Injured - Ankle. R. Moss (CB) Injured - Ribs. Z. Allen (DL) Injured - Rest. P. Surtain II (CB) Injured - Ankle.

Arizona Cardinals:  J. Gaines II (OG) Injured - Knee. D. Robinson (DL) Injured - Back. B. Baker (S) Injured - Groin. I. Seumalo (OG) Injured - Rest. J. Wills (OT) Injured - Illness. J. Sweat (LB) Injured - Rest. A. Wingard (S) Injured - Knee. G. Williams (CB) Injured - Knee. M. Melton (CB) Injured - Knee. W. Nolen III (DL) Injured - Ankle. J. Love (RB) Injured - Ankle. C. Beck (QB) Injured - Back. W. Williams Jr. (S) Injured - Concussion.

“Defensively, we were magnificent. I’m a little bit of a realist to know that 4-2 could easily be 2-4.” - Sean Payton after his team’s win against the Seahawks in their last game. 

“These guys are a resilient group. We’re learning how to play 60 minutes, and we hadn’t done that yet. Some people might disagree with me, but there’s been times when we looked like a really good football team. We’ve got to finish better in the red zone, stuff like that, but I’m happy for these guys. They put in a lot of work, they heard a lot of (stuff), and they just went to it.” - Mike LaFleur after his team’s win against the LA Rams in their last game. 

WR Sutton, Courtland

WR Waddle, Jaylen

WR Franklin, Troy

TE Engram, Evan

QB Nix, Bo

RB Dobbins, J.K.

FB Prentice, Adam

WR Brooks, Jalen

WR Wilson, Michael

WR Bourne, Kendrick

TE McBride, Trey

QB Brissett, Jacoby

RB Allgeier, Tyler

Passing: Bo Nix (1,049)

Rushing: J.K. Dobbins (270)

Receiving: Jaylen Waddle (228)

Touchdowns: Nate Adkins (2)

Passing: Jacoby Brissett (1,328)

Rushing: Jeremiyah Love (245)

Receiving: Trey McBride (361)

Touchdowns: Trey McBride (3)

Coaches:

Denver Broncos: Sean Payton (4th season)

Arizona Cardinals: Mike LaFleur (1st season)