Creighton Bluejays vs Louisville Cardinals Prediction, Picks and Game Preview - 03/20/2025

Game Time: 12:15 pm ET, Thursday, March 20, 2025

Venue:  Rupp Arena, Lexington, KY

Where to Watch:  CBS

DraftKings:  Point Spread:  Creighton +2.5, Louisville -2.5; Over/Under:  145.5 points

Bet365:  Point Spread:  Creighton +2.5, Louisville -2.5; Over/Under:  145.5 points

BetMGM:  Point Spread:  Creighton +2.5, Louisville -2.5; Over/Under:  145.5 points

Creighton Bluejays:  24-10 (15-5) (2nd place, Big East)

Louisville Cardinals:  27-7 (18-2) (2nd place, ACC)

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Creighton Bluejays:  4-1  last 5

Louisville Cardinals:  4-1  last 5

Creighton is entering this game with a 24-10 record overall, a 15-5 record in conference games, and they are 3-3 in their neutral site games this season where they will be in this game. They are coming off a loss against the St John’s Red Storm in their last game. Ryan Kalkbrenner led the team in points in that game with 15 while Jackson McAndrew was next on the team with 14. Steven Ashworth led the team in assists with 7 in that game while Ryan Kalkbrenner and Jamiya Neal each led the team in rebounds with 7. They were 43.3% from the field, 23.1% from 3-point range, and 50% from the free throw line with their shooting in that game. Their offense is averaging 75.2 PPG and their defense is allowing their opponents to average 69.5 PPG against them. Creighton has an ATS record of 19-13-2 this season and their O/U record is 16-18.

Louisville is entering this game with a 27-7 record overall, an 18-2 conference record, and they are 4-2 in their neutral site games this season where they will be in this game. They are coming off a loss against the Duke Blue Devils in their last game. Terrence Edwards Jr. led the team in points in that game with 29 while Chucky Hepburn was next on the team with 14. Terrence Edwards Jr. and Chucky Hepburn each led the team in assists with 3 in that game while Terrence Edwards Jr. and Khani Rooths each led the team in rebounds with 6. They were 39.1% from the field, 26.9% from 3-point range, and 50% from the free throw line with their shooting in that game. Their offense is averaging 78.6 PPG and their defense is allowing their opponents to average 68.9 PPG against them. Louisville has an ATS record of 20-14 this season and their O/U record is 12-22.

The current betting odds have Louisville listed as a 2.5 point favorite in this game according to Draftkings Sportsbook. Louisville has looked really good in their games this season with their 27-7 record overall and their 18-2 conference record which had them right near the top of the ACC. They are 4-2 in their neutral site games this season too, and they went to the ACC Championship before losing to Duke in the Final. Meanwhile, Creighton has looked good in their games this season with their 24-10 record overall and their 15-5 conference record which had them right near the top of the Big East. They weren't great in neutral site games this season as they are 3-3, and they haven't looked great lately. They are 4-1 in their last 5 games and are coming off a loss to St John's in the Big East Championship, but they had some close calls in that tournament, almost losing to DePaul in their first game. Louisville is also 4-1 in their last 5 games, but they have looked a lot better in their games. They are also coming off a loss in their last one, losing to Duke in the ACC Championship, but they looked a lot better against tougher opponents in their conference. They are also going to have a big advantage here since this game is in Kentucky so it is going to be more of a home game for Louisville with the crowd on their side. Creighton has been really good all season as they were the 2nd best team in the Big East for the regular season, but lately they have looked shaky and Louisville can take advantage of that with the crowd more on their side here. The best way to place a bet here is on Louisville to cover the spread in this game. 

Creighton Louisville Prediction:  Our NCAAB Pick for Thursday, March 20, 2025 (12:15 pm ET start time) is Louisville 70 Creighton 63.

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Creighton Bluejays: 12-6 ATS off a loss against a conference rival. 22-12 ATS after playing a road game. 32-23 ATS versus good shooting teams - making 45% of their shots or more. 34-21 UNDER versus good shooting teams - making 45% of their shots or more. 30-17 UNDER versus very good teams - outscoring their opponents by 8+ points/game.

Louisville Cardinals: 10-21 ATS in non-conference games. 22-32 ATS after 1 or more consecutive losses. 11-26 1H ATS off a loss against a conference rival. 10-3 UNDER when the line is +3 to -3. 20-13 UNDER in non-conference games. 17-8 UNDER versus teams who average 6 or less steals/game on the season.

Creighton Bluejays:  F. Žugić (G) Probable - Ankle. P. Isaacs (G) Out - Hip.

Louisville Cardinals:  R. Smith (G) Probable - Ankle. K. Pryor (F) Out - Leg. K. Johnson (G) Out - Shoulder.

“Well, congrats to St. John's. They've had a remarkable year. Dominated our league and pretty much saved their best for this conference tournament. They just wear into you over time.” - Greg McDermott after his team’s loss against St John’s in the Big East Tournament.

"First of all, I just want to say how fortunate we are and excited we are to be playing in the national tournament and representing our school and our city. I'll be completely honest with you, when we were watching the Selection Show and that popped up, it hurt a little bit. You felt slighted a little bit.” - Pat Kelsey on his team’s seeding in the NCAA Tournament.

S. Ashworth 

J. Green 

R. Kalkbrenner 

J. McAndrew 

J. Neal

T. Edwards 

J. Hadley 

C. Hepburn 

J. Scott 

R. Smith

PPG: R. Kalkbrenner (19.4)

APG: S. Ashworth (7)

Reb/G: R. Kalkbrenner (9)

PPG: C. Hepburn (16.3)

APG: C. Hepburn (5.9)

Reb/G: J. Hadley (7.4)

Coaches:

Creighton Bluejays: Greg McDermott (15th season)

Louisville Cardinals: Pat Kelsey (1st season)