Cleveland Guardians vs New York Yankees Prediction, Preview and Odds - 06/04/2026

Game Time: 1:35 pm ET, Thursday, June 4, 2026

Venue:  Yankee Stadium, Bronx, NY

Where to Watch:  MLB TV

DraftKings:  Moneyline odds:  Guardians +139, Yankees -168; Over/Under:  8 runs

Bet365:  Moneyline odds:  Guardians +140, Yankees -170; Over/Under:  7.5 runs

BetMGM:  Moneyline odds:  Guardians +145, Yankees -175; Over/Under:  8 runs

Cleveland Guardians:  35-27 (1st place, AL Central)

New York Yankees:  36-24 (2nd place, AL East)

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Cleveland Guardians:  5-5 last 10

New York Yankees:  6-4 last 10

The Guardians are entering this series off a loss and lost their 3-game series against the Boston Red Sox 2-1 in their last series. They enter this game with a 35-27 record overall and have a road record of 18-13. This is the series finale of a 3-game series with the Yankees on Thursday with the 2nd game still to be played on Wednesday. The Guardians won the series opener on Tuesday. Their offense ranks 23rd in the MLB with a .696 OPS. Gavin Williams is their starting pitcher on Wednesday while Slade Cecconi is making his start in this game on Thursday. He is 3-5 with a 5.25 ERA this season. His team won 5 of their last 6 games this season with him making an appearance. In his last MLB regular season appearance, he allowed 3 ER, 0 HR, and 0 BB with 3 SO on 7 hits through 4.1 IP against the Boston Red Sox.

The Yankees are entering this series off a win and won their 3-game series against the Athletics 2-1 in their last series. They enter this game with a 36-24 record overall and have a home record of 17-10. This is the 3rd game of a 3-game series with the Guardians on Thursday with the 2nd game still to be played on Wednesday. The Yankees lost the 1st game of this series on Tuesday. Their offense ranks 2nd in the MLB with a .767 OPS. Gerrit Cole is their starting pitcher on Wednesday while Carlos Rodón is making his start in this game on Thursday. He is 1-2 with a 3.32 ERA this season. His team lost 3 of their last 4 games this season with him making an appearance. In his last MLB regular season start, he allowed 1 earned run, 1 homer, and 2 walks with 3 strikeouts on 4 hits through 6 innings pitched against the Athletics.

The current betting odds have the Yankees listed as a favorite in this game according to Draftkings Sportsbook. The Yankees have looked really good in their games this season with their 36-24 record overall which has them right near the top of the AL East. They have looked great in their own ballpark too with their 17-10 home record this season. Meanwhile, the Guardians have looked good in their games this season with their 35-27 record overall which has them right at the top of the AL Central. They have been a good road team too with their 18-13 road record this year. The Guardians have been rolling over the last few weeks, but now they are 5-5 in their last 10 games and have been starting to slip. Their offense hasn't looked nearly as good lately and they aren't going to have a solid starter in this one. The Guardians are going with Cecconi in this one and he hasn't looked great this season. He is 3-5 with a 5.25 ERA and has been giving up quite a few runs all season. The team has been having a ton of success with him lately, winning 5 of their last 6 games with him starting, but he did give up 3 earned runs in his last start and that has been a common theme for him. The Yankees are going with Rodon in this one and he hasn't looked bad this year. He is 1-2 with a 3.32 ERA and the team hasn't had a lot of success with him, but he hasn't been giving up a lot of runs in his starts. The team has lost 3 of their 4 games this season with him starting, but he only gave up 1 earned run in his last start and he has been getting better in every start too. The Yankees are due for some success with how well Rodon is starting to pitch now, and the Guardians have been overachieving lately with Cecconi in his starts. Look for the Yankees to bring their best effort here and start getting Rodon some wins as he pitches better. The best way to place a bet here is on the Yankees to win this game. 

Guardians Yankees Prediction:  Our MLB Pick for Thursday, June 4, 2026 (1:35 pm ET start time) is Yankees 6 Guardians 3.

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Cleveland Guardians: 220-178 (+39 units) on the moneyline in all games. 104-94 (+26.1 units) on the moneyline in road games. 80-94 (+11.5 units) on the moneyline as an underdog of +100 or higher. 77-45 UNDER as a road underdog of +100 or higher.

New York Yankees: 234-170 (-14.9 units) on the moneyline in all games. 118-83 (-19.4 units) on the moneyline in home games. 202-140 (-20.8 units) on the moneyline as a favorite of -110 or higher. 4-1 UNDER when playing against a good team (Win Pct. 54% to 62%).

Cleveland Guardians:  G. Arias (SS) Sixty Day IL - Hamstring. E. Sabrowski (RP) Fifteen Day IL - Elbow.

New York Yankees:  A. Judge (RF) Day To Day - Rib. M. Fried (SP) Fifteen Day IL - Elbow. J. Dominguez (LF) Ten Day IL - Shoulder. G. Stanton (DH) Ten Day IL - Leg. A. Chivilli (RP) Fifteen Day IL - Shoulder. C. Schmidt (SP) Sixty Day IL - Elbow.

“Travis, since he's gotten here, has been a professional hitter. We knew that before he got here. He takes his walks, makes good swing decisions. He's facing guys with stuff that he's never seen before. The learning curve for guys coming up from the Minor Leagues, they've never seen some of this stuff before, so to be able to make adjustments like that [is important]. He's got really good adjustability, he's got really good swing decisions. Travis has been phenomenal.” - Stephen Vogt on Travis Bazzana after his team’s win against the Yankees in their game on Tuesday.

“We didn’t hold them down enough tonight. We gave ourselves a chance.” - Aaron Boone after his team’s loss against the Guardians in their game on Tuesday. 

Travis Bazzana (L) 2B

José Ramírez (S) 3B

Chase DeLauter (L) DH

Kyle Manzardo (L) 1B

Angel Martínez (S) RF

Daniel Schneemann (L) CF

Steven Kwan (L) LF

Patrick Bailey (S) C

Brayan Rocchio (S) SS

Ben Rice (L) 1B

Paul Goldschmidt (R) DH

Cody Bellinger (L) LF

Amed Rosario (R) 3B

Trent Grisham (L) CF

Anthony Volpe (R) SS

Jazz Chisholm Jr. (L) 2B

José Caballero (R) RF

Austin Wells (L) C

Batting Average:  Brayan Rocchio (.295)

Hits:  Brayan Rocchio (56)

Home Runs:  Angel Martínez (9)

RBI:  Chase DeLauter (32)

Stolen Bases:  José Ramírez (20)

Wins:  Gavin Williams (8)

Saves:  Cade Smith (20)

ERA:  Logan Allen (0.00)

Batting Average:  Ben Rice (.305)

Hits:  Ben Rice (61)

Home Runs:  Aaron Judge (17)

RBI:  Ben Rice (44)

Stolen Bases:  José Caballero (15)

Wins:  Cam Schlittler (7)

Saves:  David Bednar (12)

ERA:  Gerrit Cole (0.00)

Managers:

Cleveland Guardians: Stephen Vogt (3rd season)

New York Yankees: Aaron Boone (9th season)