Cleveland Guardians vs New York Yankees Prediction, Preview and Odds - 06/04/2025

Game Time: 7:05 pm ET, Wednesday, June 4, 2025

Venue:  Yankee Stadium, Bronx, NY

Where to Watch:  Prime Video

DraftKings:  Moneyline odds:  Guardians +154, Yankees -185; Over/Under:  8.5 runs

Bet365:  Moneyline odds:  Guardians +155, Yankees -185; Over/Under:  8.5 runs

BetMGM:  Moneyline odds:  Guardians +155, Yankees -185; Over/Under:  8.5 runs

Cleveland Guardians:  32-26 (2nd place, AL Central)

New York Yankees:  36-22 (1st place, AL East)

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Cleveland Guardians:  6-4 last 10

New York Yankees:  7-3 last 10

The Guardians are entering this series off a win and won their 3-game series against the Los Angeles Angels 2-1 in their last series. They enter this game with a 32-26 record overall and have a road record of 15-15. This is the 2nd game of a 3-game series with the Yankees on Wednesday with the series opener still to be played on Tuesday. Their offense ranks 22nd in the MLB with a .688 OPS. Tanner Bibee is their starting pitcher on Tuesday while Luis Ortiz is making his start in this game on Wednesday. He is 2-6 with a 4.40 ERA this season. His team lost 4 of their last 5 games this season with him making an appearance. In his last MLB regular season start, he allowed 1 ER, 0 HR, and 2 BB with 5 Ks on 7 hits through 6 IP against the Los Angeles Angels.

The Yankees are entering this series off a win and lost their 3-game series against the Los Angeles Dodgers 2-1 in their last series. They enter this game with a 36-22 record overall and have a home record of 18-9. This is the 2nd game of a 3-game series with the Guardians on Wednesday with the 1st game of this series still to be played on Tuesday. Their offense ranks 1st in the MLB with a .813 OPS. Carlos Rodón is their starting pitcher on Tuesday while Clarke Schmidt is making his start in this game on Wednesday. He is 2-2 with a 3.95 ERA this season. His team lost 2 of their last 3 games this season with him making an appearance. In his last MLB regular season start, he allowed 0 earned runs, 0 homers, and 1 BB with 4 strikeouts on 4 hits through 6 innings played against the Los Angeles Angels.

The current betting odds have the Yankees listed as a favorite in this game according to Draftkings Sportsbook. The Yankees have looked really good in their games this season with their 36-22 record overall which has them at the top of the AL East with one of the best records in the entire MLB. They have also looked great in their own ballpark this year with their 18-9 home record. Meanwhile, the Guardians have looked good in their games this season with their 32-26 record overall which has them right near the top of the AL Central. They haven't been a great road team this year though with their 15-15 road record. The Yankees lost their last series to the Dodgers, but they have still been really hot lately as they are 7-3 in their last 10 games. They also have the better pitching matchup in this game and can take advantage of that. Schmidt is on the mound for the Yankees and he hasn't looked bad this season. The team has lost 2 of the last 3 games that he started in, but he is 2-2 this season with a 3.95 ERA and he gave up no runs in his last start too. The Guardians are going with Ortiz in this one and he hasn't looked great this season. He is 2-6 with a 4.40 ERA and the team hasn't had a ton of success with him. They have lost 4 of the last 5 games that he started in and even though he only gave up 1 earned run in his last start, that hasn't been a common theme for him this year. The Yankees will get plenty of opportunities to put up runs in this game. The best way to place a bet here is on the Yankees to win this game. 

Guardians Yankees Prediction:  Our MLB Pick for Wednesday, June 4, 2025 (7:05 pm ET start time) is Yankees 6 Guardians 2.

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Cleveland Guardians: 92-104 (-9.2 units) on the moneyline in road games. 76-99 (-4.2 units) on the moneyline as an underdog of +100 or higher. 49-64 (-9.8 units) on the moneyline vs. teams outscoring opp by 0.5 or more runs/game on the season. 21-11 UNDER when playing against a top-level team (Win Pct. > 62%).

New York Yankees: 54-27 (+16.4 units) on the moneyline against AL Central opponents. 47-22 (+11.1 units) on the moneyline as a home favorite of -150 to -200. 176-132 (+14.7 units) on the moneyline against right-handed starters. 50-30 UNDER against AL Central opponents.

Cleveland Guardians:  A. Walters (RP) Fifteen Day IL - Arm. L. Thomas (CF) Ten Day IL - Foot. B. Lively (SP) Sixty Day IL - Forearm. W. Brennan (RF) Ten Day IL - Forearm. P. Sewald (RP) Fifteen Day IL - Shoulder. S. Bieber (SP) Sixty Day IL - Elbow. E. Sabrowski (RP) Sixty Day IL - Elbow. T. Stephan (RP) Sixty Day IL - Elbow. J. Means (SP) Sixty Day IL - Elbow. S. Hentges (RP) Sixty Day IL - Shoulder.

New York Yankees:  F. Cruz (RP) Fifteen Day IL - Shoulder. O. Cabrera (3B) Ten Day IL - Ankle. J. Chisholm Jr. (2B) Ten Day IL - Side. G. Stanton (DH) Sixty Day IL - Elbow. M. Stroman (SP) Fifteen Day IL - Knee. J. Brubaker (SP) Sixty Day IL - Ribs. J. Cousins (RP) Sixty Day IL - Elbow. L. Pacheco (SP) Sixty Day IL - Back. G. Cole (SP) Sixty Day IL - Elbow.

“[Nolan] hits the ball really hard. We know that. He's had good at-bats, just hasn't gotten the results. It was nice to see him get a three-hit day on Wednesday. It was nice to see him get three results. And I think just a day like that can get you going. It reminds you, ‘Yes, I still can get hits,’ because you start to wonder sometimes. You're hitting the ball hard, you're hitting it all over the place, but it's always getting caught. So we know what Nolan's capable of, and I think he's getting ready to break out.” - Stephen Vogt after his team’s win against the LA Angels in their game on Sunday.

“This team has bounced back from whatever tough losses we’ve had. We’ve had a handful of them in the first couple of months. They played a really great game to give us a really good trip going back home.” - Aaron Boone after his team’s win against the LA Dodgers in their game on Sunday.

Steven Kwan (L) LF

Angel Martínez (S) CF

José Ramírez (S) 3B

Kyle Manzardo (L) 1B

Carlos Santana (S) DH

Daniel Schneemann (L) 2B

Bo Naylor (L) C

Gabriel Arias (R) SS

Nolan Jones (L) RF

Paul Goldschmidt (R) 1B

Trent Grisham (L) CF

Aaron Judge (R) RF

Ben Rice (L) DH

Jasson Domínguez (S) LF

Anthony Volpe (R) SS

Austin Wells (L) C

DJ LeMahieu (R) 2B

Oswald Peraza (R) 3B

Batting Average:  José Ramírez (.327)

Hits:  Steven Kwan (70)

Home Runs:  José Ramírez (11)

RBI:  José Ramírez (29)

Stolen Bases:  José Ramírez (14)

Wins:  Gavin Williams (5)

Saves:  Emmanuel Clase (13)

ERA:  Hunter Gaddis (1.14)

Batting Average:  Aaron Judge (.391)

Hits:  Aaron Judge (86)

Home Runs:  Aaron Judge (21)

RBI:  Aaron Judge (50)

Stolen Bases:  Jasson Domínguez (8)

Wins:  Max Fried (7)

Saves:  Luke Weaver (8)

ERA:  Adam Ottavino (0.00)

Managers:

Cleveland Guardians: Stephen Vogt (2nd season)

New York Yankees: Aaron Boone (8th season)