Cleveland Guardians vs New York Yankees Prediction, Preview and Odds - 06/03/2026

Game Time: 7:05 pm ET, Wednesday, June 3, 2026

Venue:  Yankee Stadium, Bronx, NY

Where to Watch:  MLB TV, Prime Video

DraftKings:  Moneyline odds:  Guardians +135, Yankees -163; Over/Under:  7.5 runs

Bet365:  Moneyline odds:  Guardians +135, Yankees -165; Over/Under:  7.5 runs

BetMGM:  Moneyline odds:  Guardians +135, Yankees -165; Over/Under:  7.5 runs

Cleveland Guardians:  34-27 (1st place, AL Central)

New York Yankees:  36-23 (2nd place, AL East)

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Cleveland Guardians:  5-5 last 10

New York Yankees:  6-4 last 10

The Guardians are entering this series off a loss and lost their 3-game series against the Boston Red Sox 2-1 in their last series. They enter this game with a 34-27 record overall and have a road record of 17-13. This is the 2nd game of a 3-game series with the Yankees on Wednesday with the series opener still to be played on Tuesday. Their offense ranks 24th in the MLB with a .692 OPS. Joey Cantillo is their starting pitcher on Tuesday while Gavin Williams is making his start in this game on Wednesday. He is 8-3 with a 3.07 ERA this season. His team won their last 3 straight games this season with him making an appearance. In his last MLB regular season appearance, he allowed 1 ER, 0 HR, and 2 BB with 4 SO on 3 hits through 7 IP against the Washington Nationals.

The Yankees are entering this series off a win and won their 3-game series against the Athletics 2-1 in their last series. They enter this game with a 36-23 record overall and have a home record of 17-9. This is the 2nd game of a 3-game series with the Guardians on Wednesday with the series opener still to be played on Tuesday. Their offense ranks 2nd in the MLB with a .770 OPS. Cam Schlittler is their starting pitcher on Tuesday while Gerrit Cole is making his start in this game on Wednesday. He is 1-0 with a 0.00 ERA this season. His team won their last game this season with him making an appearance. In his last MLB regular season start, he allowed 0 earned runs, 0 homers, and 0 walks with 10 strikeouts on 4 hits through 6.2 innings pitched against the Kansas City Royals.

The current betting odds have the Yankees listed as a favorite in this game according to Draftkings Sportsbook. The Yankees have looked really good in their games this season with their 36-23 record overall which has them right near the top of the AL East. They have looked great in their own ballpark too with their 17-9 home record this season. Meanwhile, the Guardians have looked good in their games this season with their 34-27 record overall which has them right at the top of the AL Central. They have been a good road team too with their 17-13 road record this year. The Guardians were really hot over the last few weeks, but now they are 5-5 in their last 10 games and have really cooled off lately. The Yankees have been getting hot though, going 6-4 in their last 10 games with one of the best offenses in MLB too, and they are going to have the better pitching matchup in this one. The Guardians are going with Williams in this one and he has looked really good this season. He is 8-3 with a 3.07 ERA and the team has been having a lot of success with him too. They have won 3 games in a row now with him starting and he is off a start in which he only gave up 1 earned run, but the Guardians offense has also been going downhill lately and that could be a big issue in this one. The Yankees are also going to have a solid starter on the mound here with Cole. He is 1-0 with a 0.00 ERA and hasn't given up a run in both of his starts. He just came back from an injury after missing the last year, but he has looked great in his return and the team did win their last game with him starting. Cole is going to continue to pitch well here against a Guardians offense that hasn't looked as good lately and the Yankees much better offense will be enough to carry them here. The best way to place a bet here is on the Yankees to win this game. 

Guardians Yankees Prediction:  Our MLB Pick for Wednesday, June 3, 2026 (7:05 pm ET start time) is Yankees 3 Guardians 1.

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Cleveland Guardians: 219-178 (+37.2 units) on the moneyline in all games. 103-94 (+24.3 units) on the moneyline in road games. 79-94 (+9.7 units) on the moneyline as an underdog of +100 or higher. 77-44 UNDER as a road underdog of +100 or higher.

New York Yankees: 234-169 (-13 units) on the moneyline in all games. 118-82 (-17.5 units) on the moneyline in home games. 202-139 (-18.8 units) on the moneyline as a favorite of -110 or higher. 10-4 UNDER when the total is 7 to 7.5.

Cleveland Guardians:  A. Martinez (LF) Day To Day - Foot. G. Arias (SS) Sixty Day IL - Hamstring. E. Sabrowski (RP) Fifteen Day IL - Elbow.

New York Yankees:  M. Fried (SP) Fifteen Day IL - Elbow. J. Dominguez (LF) Ten Day IL - Shoulder. G. Stanton (DH) Ten Day IL - Leg. A. Chivilli (RP) Fifteen Day IL - Shoulder. C. Schmidt (SP) Sixty Day IL - Elbow.

“That's something we need to get better with. We need to be better. We need to extend leads.” - Stephen Vogt on his team’s trouble with extending their lead in games this season. 

“I don’t think the prettiest game on either side necessarily, but we were able to make a really outstanding inning stand up.” - Aaron Boone after his team’s win against the Athletics in their game on Sunday. 

Travis Bazzana (L) 2B

José Ramírez (S) 3B

Chase DeLauter (L) RF

Rhys Hoskins (R) DH

David Fry (R) LF

Kyle Manzardo (L) 1B

Stuart Fairchild (R) CF

Austin Hedges (R) C

Brayan Rocchio (S) SS

Paul Goldschmidt (R) 1B

Ben Rice (L) DH

Aaron Judge (R) RF

Cody Bellinger (L) LF

José Caballero (R) 3B

Trent Grisham (L) CF

Anthony Volpe (R) SS

Max Schuemann (R) 2B

Austin Wells (L) C

Batting Average:  Travis Bazzana (.294)

Hits:  Chase DeLauter (55)

Home Runs:  Angel Martínez (9)

RBI:  Chase DeLauter (32)

Stolen Bases:  José Ramírez (20)

Wins:  Gavin Williams (8)

Saves:  Cade Smith (20)

ERA:  Logan Allen (0.00)

Batting Average:  Ben Rice (.306)

Hits:  Ben Rice (60)

Home Runs:  Aaron Judge (17)

RBI:  Ben Rice (44)

Stolen Bases:  José Caballero (14)

Wins:  Cam Schlittler (7)

Saves:  David Bednar (12)

ERA:  Gerrit Cole (0.00)

Managers:

Cleveland Guardians: Stephen Vogt (3rd season)

New York Yankees: Aaron Boone (9th season)