Cleveland Guardians vs New York Yankees Prediction, Preview and Odds - 06/03/2025

Game Time: 7:05 pm ET, Tuesday, June 3, 2025

Venue:  Yankee Stadium, Bronx, NY

Where to Watch:  YES

DraftKings:  Moneyline odds:  Guardians +150, Yankees -180; Over/Under:  8 runs

Bet365:  Moneyline odds:  Guardians +150, Yankees -180; Over/Under:  8 runs

BetMGM:  Moneyline odds:  Guardians +150, Yankees -185; Over/Under:  8 runs

Cleveland Guardians:  32-26 (2nd place, AL Central)

New York Yankees:  36-22 (1st place, AL East)

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Cleveland Guardians:  6-4 last 10

New York Yankees:  7-3 last 10

The Guardians are entering this series off a win and won their 3-game series against the Los Angeles Angels 2-1 in their last series. They enter this game with a 32-26 record overall and have a road record of 15-15. This is the series opener of a 3-game series with the Yankees on Tuesday and they have Monday off as a day of rest. Their offense ranks 21st in the MLB with a .688 OPS. Gavin Williams was their starting pitcher on Sunday while Tanner Bibee is making his start in this game on Tuesday. He is 4-5 with a 3.86 ERA this season. His team lost 3 of their last 4 games this season with him making an appearance. In his last MLB regular season start, he allowed 4 ER, 1 HR, and 3 BB with 7 Ks on 7 hits through 5 IP against the Los Angeles Dodgers.

The Yankees are entering this series off a win and lost their 3-game series against the Los Angeles Dodgers 2-1 in their last series. They enter this game with a 36-22 record overall and have a home record of 18-9. This is the 1st game of a 3-game series with the Guardians on Tuesday and they have Monday off as a day of rest. Their offense ranks 2nd in the MLB with a .813 OPS. Ryan Yarbrough was their starting pitcher on Sunday while Carlos Rodón is making his start in this game on Tuesday. He is 7-3 with a 2.60 ERA this season. His team won their last 3 straight games this season with him making an appearance. In his last MLB regular season start, he allowed 0 earned runs, 0 homers, and 0 BB with 10 strikeouts on 5 hits through 7 innings played against the Los Angeles Angels.

The current betting odds have the Yankees listed as a favorite in this game according to Draftkings Sportsbook. The Yankees have looked really good in their games this season with their 36-22 record overall which has them at the top of the AL East with one of the best records in the entire MLB. They have also looked great in their own ballpark this year with their 18-9 home record. Meanwhile, the Guardians have looked good in their games this season with their 32-26 record overall which has them right near the top of the AL Central. They haven't been a great road team this year though with their 15-15 road record. The Guardians have a great pitching staff and they have been leaning on that going back to last season too, but they don't have a great offense and that will be a problem in games like these when they don't have the better pitching matchup either. The Guardians are going with Bibee in this one and he hasn't looked great this year. He is 4-5 with a 3.86 ERA this season and he has been giving up a lot more runs in his starts this year. He gave up 4 earned runs in his last start too and even the team has lost 3 of their last 4 games with him starting. The Yankees are going with Rodon in this one and he has looked great all season. He is 7-3 with a 2.60 ERA and he is coming off a start in which he gave up no runs. The team has also won 3 games in a row now with him starting and even though they lost their last series to the Dodgers, they will be looking to bounce back as they are still 7-3 in their last 10 games and have been hot lately. The best way to place a bet here is on the Yankees to win this game. 

Guardians Yankees Prediction:  Our MLB Pick for Tuesday, June 3, 2025 (7:05 pm ET start time) is Yankees 5 Guardians 1.

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Cleveland Guardians: 92-104 (-9.2 units) on the moneyline in road games. 76-99 (-4.2 units) on the moneyline as an underdog of +100 or higher. 59-57 (-5.2 units) on the moneyline against left-handed starters. 21-11 UNDER when playing against a top-level team (Win Pct. > 62%).

New York Yankees: 54-27 (+16.4 units) on the moneyline against AL Central opponents. 47-22 (+11.1 units) on the moneyline as a home favorite of -150 to -200. 176-132 (+14.7 units) on the moneyline against right-handed starters. 50-30 UNDER against AL Central opponents.

Cleveland Guardians:  A. Walters (RP) Fifteen Day IL - Arm. L. Thomas (CF) Ten Day IL - Foot. B. Lively (SP) Sixty Day IL - Forearm. W. Brennan (RF) Ten Day IL - Forearm. P. Sewald (RP) Fifteen Day IL - Shoulder. S. Bieber (SP) Sixty Day IL - Elbow. E. Sabrowski (RP) Sixty Day IL - Elbow. T. Stephan (RP) Sixty Day IL - Elbow. J. Means (SP) Sixty Day IL - Elbow. S. Hentges (RP) Sixty Day IL - Shoulder.

New York Yankees:  F. Cruz (RP) Fifteen Day IL - Shoulder. O. Cabrera (3B) Ten Day IL - Ankle. J. Chisholm Jr. (2B) Ten Day IL - Side. G. Stanton (DH) Sixty Day IL - Elbow. M. Stroman (SP) Fifteen Day IL - Knee. J. Brubaker (SP) Sixty Day IL - Ribs. J. Cousins (RP) Sixty Day IL - Elbow. L. Pacheco (SP) Sixty Day IL - Back. G. Cole (SP) Sixty Day IL - Elbow.

“[Nolan] hits the ball really hard. We know that. He's had good at-bats, just hasn't gotten the results. It was nice to see him get a three-hit day on Wednesday. It was nice to see him get three results. And I think just a day like that can get you going. It reminds you, ‘Yes, I still can get hits,’ because you start to wonder sometimes. You're hitting the ball hard, you're hitting it all over the place, but it's always getting caught. So we know what Nolan's capable of, and I think he's getting ready to break out.” - Stephen Vogt after his team’s win against the LA Angels in their game on Sunday.

“This team has bounced back from whatever tough losses we’ve had. We’ve had a handful of them in the first couple of months. They played a really great game to give us a really good trip going back home.” - Aaron Boone after his team’s win against the LA Dodgers in their game on Sunday.

Steven Kwan (L) LF

Angel Martínez (S) CF

José Ramírez (S) 3B

Kyle Manzardo (L) 1B

Carlos Santana (S) DH

Daniel Schneemann (L) 2B

Bo Naylor (L) C

Gabriel Arias (R) SS

Nolan Jones (L) RF

Paul Goldschmidt (R) 1B

Trent Grisham (L) CF

Aaron Judge (R) RF

Ben Rice (L) DH

Jasson Domínguez (S) LF

Anthony Volpe (R) SS

Austin Wells (L) C

DJ LeMahieu (R) 2B

Oswald Peraza (R) 3B

Batting Average:  José Ramírez (.327)

Hits:  Steven Kwan (70)

Home Runs:  José Ramírez (11)

RBI:  José Ramírez (29)

Stolen Bases:  José Ramírez (14)

Wins:  Gavin Williams (5)

Saves:  Emmanuel Clase (13)

ERA:  Hunter Gaddis (1.14)

Batting Average:  Aaron Judge (.391)

Hits:  Aaron Judge (86)

Home Runs:  Aaron Judge (21)

RBI:  Aaron Judge (50)

Stolen Bases:  Jasson Domínguez (8)

Wins:  Max Fried (7)

Saves:  Luke Weaver (8)

ERA:  Adam Ottavino (0.00)

Managers:

Cleveland Guardians: Stephen Vogt (2nd season)

New York Yankees: Aaron Boone (8th season)