Cleveland Guardians vs New York Yankees Prediction, Preview and Odds - 06/02/2026

Game Time: 7:05 pm ET, Tuesday, June 2, 2026

Venue:  Yankee Stadium, Bronx, NY

Where to Watch:  MLB TV

DraftKings:  Moneyline odds:  Guardians +179, Yankees -219; Over/Under:  7.5 runs

Bet365:  Moneyline odds:  Guardians +180, Yankees -225; Over/Under:  7.5 runs

BetMGM:  Moneyline odds:  Guardians +180, Yankees -225; Over/Under:  7.5 runs

Cleveland Guardians:  34-27 (1st place, AL Central)

New York Yankees:  36-23 (2nd place, AL East)

Do not miss out on our expert handicapper analysis! Amedeus Mastrangelo is on a HOT STREAK in MLB on a 21-8 MLB RUN for +$12,920 PROFIT! Make sure you check out his picks and many more from the expert handicappers featured in the Shop Picks section.

Cleveland Guardians:  5-5 last 10

New York Yankees:  6-4 last 10

The Guardians are entering this series off a loss and lost their 3-game series against the Boston Red Sox 2-1 in their last series. They enter this game with a 34-27 record overall and have a road record of 17-13. This is the series opener of a 3-game series with the Yankees on Tuesday and they have Monday off as a day of rest. Their offense ranks 22nd in the MLB with a .691 OPS. Tanner Bibee was their starting pitcher on Sunday while Joey Cantillo is making his start in this game on Tuesday. He is 4-2 with a 3.57 ERA this season. His team won 5 of their last 6 games this season with him making an appearance. In his last MLB regular season appearance, he allowed 4 ER, 1 HR, and 4 BB with 1 SO on 3 hits through 2 IP against the Washington Nationals.

The Yankees are entering this series off a win and won their 3-game series against the Athletics 2-1 in their last series. They enter this game with a 36-23 record overall and have a home record of 17-9. This is the 1st game of a 3-game series with the Guardians on Tuesday and they have Monday off as a day of rest. Their offense ranks 2nd in the MLB with a .770 OPS. Will Warren was their starting pitcher on Sunday while Cam Schlittler is making his start in this game on Tuesday. He is 7-2 with a 1.50 ERA this season. His team won 2 of their last 3 games this season with him making an appearance. In his last MLB regular season start, he allowed 1 earned run, 1 homer, and 0 walks with 6 strikeouts on 4 hits through 6 innings pitched against the Kansas City Royals.

The current betting odds have the Yankees listed as a big favorite in this game according to Draftkings Sportsbook. The Yankees have looked really good in their games this season with their 36-23 record overall which has them right near the top of the AL East. They have looked great in their own ballpark too with their 17-9 home record this season. Meanwhile, the Guardians have looked good in their games this season with their 34-27 record overall which has them right at the top of the AL Central. They have been a good road team too with their 17-13 road record this year. The Guardians were rolling over the last few weeks, but now they are 5-5 in their last 10 games and have been cooling off lately, off a series loss to the Red Sox in their last one. The Yankees are 6-4 in their last 10 games and they have been getting hot again with one of the best offenses in MLB. The Yankees also have the better pitching matchup in this one and they will be able to take advantage of that with their hot offense. Schlittler is on the mound for the Yankees in this one and he has looked great this season. He is 7-2 with a 1.50 ERA and the team has been having a ton of success with him. They have won 2 of their last 3 games with him starting and he is off another great start in which he gave up 1 earned run, something that has been a common theme for him. The Guardians are going with Cantillo in this one and he hasn't been bad this year. He is 4-2 with a 3.57 ERA, but he hasn't looked nearly as good as Schlittler has and Cantillo has also been giving up more runs lately. The team has been having success with him as they have won 5 of their last 6 games with him starting, but he did give up 4 earned runs in his last start and that will be a big issue against this Yankees offense. Look for the Yankees to take advantage of this pitching matchup and continue to roll with the better offense here. The best way to place a bet here is on the Yankees to win this game and on the runline. 

Guardians Yankees Prediction:  Our MLB Pick for Tuesday, June 2, 2026 (7:05 pm ET start time) is Yankees 7 Guardians 1.

Don't miss our champion handicappers free picks, best bets, and expert baseball picks today.  And if you enjoyed this Cleveland Guardians New York Yankees prediction, be sure to drop by every day for our daily MLB projections and previews.

Cleveland Guardians: 219-178 (+37.2 units) on the moneyline in all games. 103-94 (+24.3 units) on the moneyline in road games. 79-94 (+9.7 units) on the moneyline as an underdog of +100 or higher. 31-12 UNDER as a road underdog of +150 or more.

New York Yankees: 234-169 (-13 units) on the moneyline in all games. 118-82 (-17.5 units) on the moneyline in home games. 202-139 (-18.8 units) on the moneyline as a favorite of -110 or higher. 46-27 UNDER as a favorite of -175 to -250.

Cleveland Guardians:  A. Martinez (LF) Day To Day - Foot. G. Arias (SS) Sixty Day IL - Hamstring. E. Sabrowski (RP) Fifteen Day IL - Elbow.

New York Yankees:  M. Fried (SP) Fifteen Day IL - Elbow. J. Dominguez (LF) Ten Day IL - Shoulder. G. Stanton (DH) Ten Day IL - Leg. A. Chivilli (RP) Fifteen Day IL - Shoulder. C. Schmidt (SP) Sixty Day IL - Elbow.

“That's something we need to get better with. We need to be better. We need to extend leads.” - Stephen Vogt on his team’s trouble with extending their lead in games this season. 

“I don’t think the prettiest game on either side necessarily, but we were able to make a really outstanding inning stand up.” - Aaron Boone after his team’s win against the Athletics in their game on Sunday. 

Travis Bazzana (L) 2B

José Ramírez (S) 3B

Chase DeLauter (L) RF

Rhys Hoskins (R) DH

David Fry (R) LF

Kyle Manzardo (L) 1B

Stuart Fairchild (R) CF

Austin Hedges (R) C

Brayan Rocchio (S) SS

Paul Goldschmidt (R) 1B

Ben Rice (L) DH

Aaron Judge (R) RF

Cody Bellinger (L) LF

José Caballero (R) 3B

Trent Grisham (L) CF

Anthony Volpe (R) SS

Max Schuemann (R) 2B

Austin Wells (L) C

Batting Average:  Travis Bazzana (.294)

Hits:  Chase DeLauter (55)

Home Runs:  Angel Martínez (9)

RBI:  Chase DeLauter (32)

Stolen Bases:  José Ramírez (20)

Wins:  Gavin Williams (8)

Saves:  Cade Smith (20)

ERA:  Logan Allen (0.00)

Batting Average:  Ben Rice (.306)

Hits:  Ben Rice (60)

Home Runs:  Aaron Judge (17)

RBI:  Ben Rice (44)

Stolen Bases:  José Caballero (14)

Wins:  Cam Schlittler (7)

Saves:  David Bednar (12)

ERA:  Gerrit Cole (0.00)

Managers:

Cleveland Guardians: Stephen Vogt (3rd season)

New York Yankees: Aaron Boone (9th season)