Cleveland Guardians vs Milwaukee Brewers Prediction, Preview and Odds - 06/17/2026

Game Time: 7:40 pm ET, Wednesday, June 17, 2026

Venue:  American Family Field, Milwaukee, WI

Where to Watch:  ESPN Unlimited, MLB TV

DraftKings:  Moneyline odds:  Guardians -101, Brewers -122; Over/Under:  7.5 runs

Bet365:  Moneyline odds:  Guardians +100, Brewers -120; Over/Under:  8 runs

BetMGM:  Moneyline odds:  Guardians +100, Brewers -120; Over/Under:  7.5 runs

Cleveland Guardians:  39-33 (2nd place, AL Central)

Milwaukee Brewers:  43-26 (1st place, NL Central)

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Cleveland Guardians:  4-6 last 10

Milwaukee Brewers:  6-4 last 10

The Guardians are entering this series off a win and completed the sweep in their 2-game series against the Detroit Tigers 2-0 in their last series. They enter this game with a 39-33 record overall and have a road record of 20-16. This is the 2nd game of a 3-game series with the Brewers on Wednesday with the series opener still to be played on Tuesday. Their offense ranks 27th in the MLB with a .689 OPS. Slade Cecconi is their starting pitcher on Tuesday while Gavin Williams is making his start in this game on Wednesday. He is 9-3 with a 3.32 ERA this season. His team won 4 of their last 5 games this season with him making an appearance. In his last MLB regular season appearance, he allowed 3 ER, 2 HR, and 3 BB with 5 SO on 4 hits through 5 IP against the New York Yankees.

The Brewers are entering this series off a win and won their 3-game series against the Philadelphia Phillies 2-1 in their last series. They enter this game with a 43-26 record overall and have a home record of 23-14. This is the 2nd game of a 3-game series with the Guardians on Wednesday with the 1st game of this series still to be played on Tuesday. Their offense ranks 8th in the MLB with a .734 OPS. Robert Gasser is their starting pitcher on Tuesday while Brandon Sproat is making his start in this game on Wednesday. He is 1-4 with a 5.70 ERA this season. His team lost 3 of their last 4 games this season with him making an appearance. In his last MLB regular season start, he allowed 1 earned run, 1 homer, and 1 walk with 3 strikeouts on 4 hits through 6 innings pitched against the Athletics.

The current betting odds have the Guardians listed as a slight underdog in this game according to Draftkings Sportsbook. The Guardians have looked good in their games this season with their 39-33 record overall which has them right near the top of the AL Central. They have been a good road team too with their 20-16 road record this year. Meanwhile, the Brewers have looked great in their games this season with their 43-26 record overall which has them right at the top of the NL Central with one of the best records in MLB. The Brewers are 6-4 in their last 10 games and have one of the best records in MLB this year, but they have been cooling off lately with their pitching staff giving up a lot more runs. The Guardians are only 4-6 in their last 10 games, but they have a great pitching staff that hasn't been giving up a lot of runs all season and this is a good series for them to bounce back in with some better starters going. Williams is on the mound for the Guardians in this one and he has been their best starter this season. He is 9-3 with a 3.32 ERA and the team has been having a ton of success with him lately. They have won 4 of their last 5 games with him starting and he gave up 3 earned runs in his last start, but he hasn't been giving up that many runs in a majority of his starts this year. The Brewers are going with Sproat in this one and he has looked terrible this season. He is 1-4 with a 5.70 ERA and his team hasn't had much success with him. He only gave up 1 earned run in his last start, but that really hasn't been a common theme for him this year and the team has still lost 3 of their last 4 games with him starting too. The Guardians can take advantage of this pitching matchup with their ace on the mound here. The best way to place a bet here is on the Guardians to win this game. 

Guardians Brewers Prediction:  Our MLB Pick for Wednesday, June 17, 2026 (7:40 pm ET start time) is Guardians 5 Brewers 1.

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Cleveland Guardians: 20-24 (-6 units) on the moneyline against NL Central opponents. 55-60 (-4.9 units) on the moneyline in an inter-league game. 46-63 (-8.3 units) on the moneyline vs. teams outscoring opp by 0.5 or more runs/game on the season. 79-47 UNDER as a road underdog of +100 or higher.

Milwaukee Brewers: 30-15 (+15.8 units) on the moneyline against AL Central opponents. 237-169 (+47.4 units) on the moneyline in all games. 125-81 (+18.7 units) on the moneyline in home games. 10-4 UNDER at home when the money line is +125 to -125.

Cleveland Guardians:  J. Ramirez (3B) Ten Day IL - Hand. X. Martinez (RP) Day To Day - Foot. C. DeLauter (RF) Day To Day - Rib Cage. E. Sabrowski (RP) Fifteen Day IL - Elbow.

Milwaukee Brewers:  C. Crow (SP) Fifteen Day IL - Forearm. B. Fitzpatrick (RP) Sixty Day IL - Elbow. C. Rodriguez (RP) Fifteen Day IL - Undisclosed. Q. Priester (SP) Sixty Day IL - Wrist. D. Hall (RP) Fifteen Day IL - Pectoral. R. Zastryzny (RP) Fifteen Day IL - Shoulder. A. Zerpa (RP) Sixty Day IL - Forearm. L. Henderson (SP) Fifteen Day IL - Back. B. Lockridge (LF) Ten Day IL - Knee. B. Woodruff (SP) Fifteen Day IL - Arm. J. Koenig (RP) Fifteen Day IL - Elbow.

“We’re trying to rule everything out right now. That’s why we got the two tests. We don’t want to put the cart before the horse with anything until our medical group has had time to review the two tests.” - Stephen Vogt on the injury to Chase DeLauter.

"I’ll tell you what: It’s a good feeling. I don’t think anyone complains about the hitting the ball over the fence. First one of the year. It’s been a while." - Blake Perkins on his home run after their win against the Phillies in their game on Sunday. 

Angel Martínez (S) LF

José Ramírez (S) 3B

Chase DeLauter (L) RF

Rhys Hoskins (R) 1B

David Fry (R) DH

Travis Bazzana (L) 2B

Stuart Fairchild (R) CF

Austin Hedges (R) C

Brayan Rocchio (S) SS

Jackson Chourio (R) LF

Andrew Vaughn (R) 1B

William Contreras (R) DH

Gary Sánchez (R) C

Luis Rengifo (S) 3B

Garrett Mitchell (L) CF

Blake Perkins (S) RF

Joey Ortiz (R) SS

David Hamilton (L) 2B

Batting Average:  Brayan Rocchio (.274)

Hits:  José Ramírez (64)

Home Runs:  Angel Martínez (11)

RBI:  Chase DeLauter (34)

Stolen Bases:  José Ramírez (24)

Wins:  Gavin Williams (9)

Saves:  Cade Smith (23)

ERA:  Logan Allen (0.00)

Batting Average:  Andrew Vaughn (.354)

Hits:  William Contreras (76)

Home Runs:  Jake Bauers (13)

RBI:  Jake Bauers (46)

Stolen Bases:  David Hamilton (14)

Wins:  Aaron Ashby (9)

Saves:  Trevor Megill (8)

ERA:  Jared Koenig (0.00)

Managers:

Cleveland Guardians: Stephen Vogt (3rd season)

Milwaukee Brewers: Pat Murphy (3rd season)