Cleveland Guardians vs Houston Astros Prediction, Preview and Odds - 07/08/2025

Game Time: 8:10 pm ET, Tuesday, July 8, 2025

Venue:  Daikin Park, Houston, TX

Where to Watch:  CLEGUARDIANS.tv, SCHN

DraftKings:  Moneyline odds:  Guardians +168, Astros -208; Over/Under:  7.5 runs

Bet365:  Moneyline odds:  Guardians +170, Astros -200; Over/Under:  7.5 runs

BetMGM:  Moneyline odds:  Guardians +165, Astros -200; Over/Under:  7.5 runs

Cleveland Guardians:  40-48 (4th place, AL Central)

Houston Astros:  55-35 (1st place, AL West)

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Cleveland Guardians:  0-10 last 10

Houston Astros:  8-2 last 10

The Guardians are entering this series off a loss and got swept in their 3-game series against the Detroit Tigers 3-0 in their last series. They enter this game with a 40-48 record overall and have a road record of 20-25. This is the 2nd game of a 3-game series with the Astros on Tuesday with the series opener still to be played on Monday. Their offense ranks 28th in the MLB with a .656 OPS. Tanner Bibee is their starting pitcher on Monday while Joey Cantillo is making his start in this game on Tuesday. He is 1-0 with a 3.41 ERA this season. His team lost their last 2 straight games this season with him making an appearance. In his last MLB regular season start, he allowed 0 ER, 0 HR, and 3 BB with 5 SO on 2 hits through 3.1 IP against the Chicago Cubs.

The Astros are entering this series off a win and completed the sweep in their 3-game series against the Los Angeles Dodgers 3-0 in their last series. They enter this game with a 55-35 record overall and have a home record of 32-14. This is the 2nd game of a 3-game series with the Guardians on Tuesday with the 1st game of this series still to be played on Monday. Their offense ranks 8th in the MLB with a .738 OPS. Rookie pitcher Colton Gordon is their starting pitcher on Monday while Hunter Brown is making his start in this game on Tuesday. He is 9-3 with a 1.82 ERA this season. His team won their last 7 straight games this season with him making an appearance. In his last MLB regular season start, he allowed 2 earned runs, 1 homer, and 1 walk with 8 strikeouts on 6 hits through 6 innings pitched against the Colorado Rockies.

The current betting odds have the Astros listed as a big favorite in this game according to Draftkings Sportsbook. The Astros have looked great in their games this season with their 55-35 record overall which has them right at the top of the AL West with one of the best records in the entire MLB. They have also looked great in their own ballpark this year with their 32-14 home record. Meanwhile, the Guardians haven't looked good in their games this season with their 40-48 record overall which has them right near the bottom of the AL Central. They haven't been a good road team either with their 20-25 road record this season. The Guardians have also been in a terrible slump lately, going 0-10 in their last 10 games while the Astros have been red hot, going 8-2 in their last 10 games and sweeping the Dodgers in their last series. The Astros have been the hotter team lately, but they also have the better offense and the better starter in this game. Brown is on the mound for the Astros in this one and he has been one of their best starters this year. He is 9-3 with a 1.82 ERA and hasn't been giving up many runs at all. He only gave up 2 earned runs in his last start which has been a common theme for him, and the team has won 7 games in a row now with him starting too. The Guardians are going with Cantillo in this one and he hasn't looked bad this season. He is 1-0 with a 3.41 ERA, but he also doesn't get a lot of starts. He did start in his last appearance and didn't give up any runs, but that won't be the case on the road against this offense. The Astros also have the better bullpen to help them out here as all signs point to the Astros winning this one. The best way to place a bet here is on the Astros to win this game and on the runline. 

Guardians Astros Prediction:  Our MLB Pick for Tuesday, July 8, 2025 (8:10 pm ET start time) is Astros 7 Guardians 1.

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Cleveland Guardians: 43-34 (+4.7 units) on the moneyline against AL West opponents. 147-144 (+6.5 units) on the moneyline vs. a team with a good bullpen whose WHIP is 1.350 or better. 38-34 (+6.4 units) on the moneyline vs. a team with a good bullpen whose ERA is 3.45 or better. 31-19 UNDER as an underdog of +150 or more.

Houston Astros: 50-40 (-8.1 units) on the moneyline against AL Central opponents. 164-127 (-27.5 units) on the moneyline as a favorite of -110 or higher. 118-97 (-25 units) on the moneyline in home games. 94-64 UNDER vs. AL teams scoring 4.4 or less runs/game on the season.

Cleveland Guardians:  L. Thomas (CF) Ten Day IL - Foot. G. Arias (SS) Ten Day IL - Ankle. W. Brennan (RF) Sixty Day IL - Forearm. A. Walters (RP) Sixty Day IL - Lat. B. Lively (SP) Sixty Day IL - Forearm. S. Bieber (SP) Sixty Day IL - Elbow. T. Stephan (RP) Sixty Day IL - Elbow. J. Means (SP) Sixty Day IL - Elbow. S. Hentges (RP) Sixty Day IL - Shoulder.

Houston Astros:  L. Guillorme (3B) Ten Day IL - Hamstring. Y. Alvarez (LF) Sixty Day IL - Hand. J. Pena (SS) Ten Day IL - Rib. S. Dubin (RP) Fifteen Day IL - Forearm. P. Leon (RF) Sixty Day IL - Knee. B. Rodgers (2B) Ten Day IL - Oblique. J. Melton (LF) Ten Day IL - Ankle. S. Arrighetti (SP) Sixty Day IL - Thumb. Z. Dezenzo (RF) Ten Day IL - Hand. R. Blanco (SP) Sixty Day IL - Elbow. C. McCormick (LF) Ten Day IL - Oblique. H. Wesneski (RP) Sixty Day IL - Elbow. L. Garcia (SP) Sixty Day IL - Elbow. C. Javier (SP) Sixty Day IL - Elbow. J. France (SP) Sixty Day IL - Shoulder.

“This game felt like a kick in the pants. It really did. Gut-wrenching. Heart-wrenching.” - Stephen Vogt after his team’s loss against the Tigers in their game on Sunday.

“It doesn’t matter who it is. This team is just how they believe in one another and what it takes to win. It takes a lot of people to win games. Zack Short, Trammell with that sliding play, Ryan Gusto with a great start, [Jose] Altuve doing his thing. Everyone’s just contributing and as a team, that’s what you do.” - Joe Espada after his team’s win against the LA Dodgers in their game on Sunday.

Steven Kwan (L) LF

David Fry (R) DH

José Ramírez (S) 3B

Carlos Santana (S) 1B

Angel Martínez (S) CF

Johnathan Rodríguez (R) RF

Will Wilson (R) 2B

Austin Hedges (R) C

Brayan Rocchio (S) SS

Isaac Paredes (R) DH

Jake Meyers (R) CF

Jose Altuve (R) 2B

Cam Smith (R) RF

Christian Walker (R) 1B

Yainer Diaz (R) C

Cooper Hummel (S) LF

Mauricio Dubón (R) 3B

Zack Short (R) SS

Batting Average:  Steven Kwan (.298)

Hits:  Steven Kwan (99)

Home Runs:  José Ramírez (14)

RBI:  José Ramírez (39)

Stolen Bases:  José Ramírez (22)

Wins:  Gavin Williams (5)

Saves:  Emmanuel Clase (18)

ERA:  Nic Enright (2.08)

Batting Average:  Zack Short (.667)

Hits:  Jeremy Peña (102)

Home Runs:  Isaac Paredes (18)

RBI:  Isaac Paredes (48)

Stolen Bases:  Jeremy Peña (15)

Wins:  Framber Valdez (10)

Saves:  Josh Hader (25)

ERA:  Shawn Dubin (1.33)

Managers:

Cleveland Guardians: Stephen Vogt (2nd season)

Houston Astros: Joe Espada (2nd season)