Game Time: 8:10 pm ET, Wednesday, May 25, 2022
Venue: Minute Maid Park, Houston, TX
Where to Watch: Sportsnet SW
Opening Odds at USA Sportsbooks
DraftKings: Moneyline odds: Guardians +155, Astros -180; Over/Under: 8 runs
Bet365: Moneyline odds: Guardians +155, Astros -180; Over/Under: 8 runs
BetMGM: Moneyline odds: Guardians +155, Astros -180; Over/Under: 8 runs
Cleveland Guardians: 18-20 (3rd place, AL Central)
Houston Astros: 27-16 (1st place, AL West)
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Cleveland Guardians vs Houston Astros Preview and Analysis
Cleveland Guardians: 4-6 last 10
Houston Astros: 5-5 last 10
Cleveland Guardians Analysis
The Guardians are coming into this game with a 18-20 record overall and they are 10-12 in their road games this season where they will be in this game. They have won 2 of their last 3 games and are coming into this one off of a win in their last game. They just split their 2-game series against the Detroit Tigers 1-1 and they are playing the series finale of a 3-game series with the Astros on Wednesday. This will be the 3rd game of the series on Wednesday with the 2nd game still to be played on Tuesday. Zach Plesac is the starting pitcher for them on Tuesday while Cal Quantrill is on the mound for them here on Wednesday. He is 1-2 with a 3.48 ERA this season. His team lost 5 of their last 6 games this season with him starting. In his last start, he allowed 1 ER, 1 HR, and 0 BB with 5 Ks on 5 hits in 7 IP against the Cincinnati Reds. They scored 8 runs in their last series averaging 4 runs scored per game in that span and they allowed 5 runs against them averaging 2.5 runs allowed per game.
Houston Astros Analysis
The Astros are coming into this game with a 27-16 record overall and they are 12-6 in their home games this season where they will be in this game. They have won 2 of their last 3 games but are coming into this one off of a loss in their last game which snapped a 2 game winning streak that they were on. They just won their 4-game series against the Texas Rangers 3-1 and they are playing the series finale of a 3-game series with the Tigers on Wednesday. This will be the 3rd game of the series on Wednesday with the 2nd game still to be played on Tuesday. Framber Valdez is the starting pitcher for them on Tuesday while Cristian Javier will be on the mound for them here on Wednesday. He is 2-2 with a 2.87 ERA this season. His team lost their last 2 straight games this season with him as a starter. In his last start, he allowed 1 earned runs, 1 homer, and 1 BB with 9 strikeouts on 3 hits in 6 innings played against the Texas Rangers. They scored 12 runs in their last series averaging 3 runs scored per game in that span and they allowed 7 runs against them averaging just under 2 runs allowed per game.
Guardians vs Astros Prediction
The Astros are coming into this game as a big favorite with the current betting odds. They have been heating up in their recent games and have been playing very well at home this season. They are going up against a Guardians team that have been playing much better recently but they still have not been playing great this season and are sitting below .500 right now. The Astros are 11 games above .500 and have double the amount wins at home than losses. They also have a much better team than the Guardians and their starter here, Javier, has been great this season in his starts. Quantrill is starting for the Guardians here and he has not been bad this season but he has also been very inconsistent and the Astros will be hungry to win here after losing the first game of this series, they will not want to drop this series at home. The best bet here is on the Astros to win this game on the runline.
Guardians Astros Prediction: Our MLB Pick for Wednesday, May 25, 2022 (8:10 pm ET start time) is Astros 5 Guardians 3.
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MLB Betting Trends
Cleveland Guardians: 51-80 (-11.1 Units) ML as an underdog of +100 or higher. 43-48 (-7.6 Units) ML when the total is 8 to 8.5. 7-3 UNDER on the road when the total is 8 to 8.5.
Houston Astros: 51-21 (+9.9 Units) ML as a favorite of -175 to -250. 43-24 (+6.2 Units) ML at home when the total is 8 to 8.5. 24-6 UNDER as a favorite of -110 or higher.
Cleveland Guardians: A. Civale (SP) Ques Wed - Buttocks. C. Morris (SP) Early June - Shoulder. J. Karinchak (RP) Out indefinitely - Back.
Houston Astros: J. Odorizzi (SP) Late June - Ankle. J. Meyers (CF) Early June - Shoulder. T. Jones (1B) Mid June - Back.
"Their lineup is potent and they're dangerous and he really pitched well. He really did. He was aggressive with his fastball, good off-speed, basically really pitched." - Terry Francona after his team’s win against the Astros on Monday.
"We gave them three runs today. We were operating with low energy." - Dusty Baker after his team’s loss against the Guardians on Monday.
Myles Straw (R) CF
Amed Rosario (R) SS
Jose Ramirez (S) 3B
Owen Miller (R) 2B
Josh Naylor (L) 1B
Franmil Reyes (R) DH
Oscar Mercado (R) RF
Ernie Clement (R) LF
Austin Hedges (R) C
Jose Altuve (R) 2B
Michael Brantley (L) DH
Alex Bregman (R) 3B
Yordan Alvarez (L) LF
Yuli Gurriel (R) 1B
Kyle Tucker (L) RF
Jeremy Pena (R) SS
Chas McCormick (R) CF
Martin Maldonado (R) C
Batting Average: Luke Maile (.333)
Hits: Jose Ramirez (41)
Home Runs: Jose Ramirez (10)
RBI: Jose Ramirez (41)
Stolen Bases: Myles Straw (8)
Wins: Nick Sandlin (3)
Saves: Emmanuel Clase (7)
ERA: Sam Hentges (1.17)
Batting Average: Jeremy Pena (.287)
Hits: Michael Brantley (40)
Home Runs: Yordan Alvarez (12)
RBI: Kyle Tucker (26)
Stolen Bases: Kyle Tucker (9)
Wins: Justin Verlander (6)
Saves: Ryan Pressly (6)
ERA: Seth Martinez (0.00)
Cleveland Guardians: Terry Francona (10th season)
Houston Astros: Dusty Baker (3rd season)