Cleveland Guardians vs Chicago White Sox Prediction, Preview and Odds - 06/24/2026

Game Time: 2:10 pm ET, Wednesday, June 24, 2026

Venue:  Rate Field, Chicago, IL

Where to Watch:  MLB TV

DraftKings:  Moneyline odds:  Guardians -126, White Sox +104; Over/Under:  9 runs

Bet365:  Moneyline odds:  Guardians -125, White Sox +105; Over/Under:  9 runs

BetMGM:  Moneyline odds:  Guardians -125, White Sox +105; Over/Under:  9 runs

Cleveland Guardians:  41-38 (2nd place, AL Central)

Chicago White Sox:  40-37 (1st place, AL Central)

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Cleveland Guardians:  4-6 last 10

Chicago White Sox:  4-6 last 10

The Guardians are entering this series off a loss and lost their 3-game series against the Houston Astros 2-1 in their last series. They enter this game with a 41-38 record overall and have a road record of 22-21. This is the series finale of a 3-game series with the White Sox on Wednesday with the 2nd game still to be played on Tuesday. The Guardians lost the series opener on Monday. Their offense ranks 28th in the MLB with a .682 OPS. Parker Messick is their starting pitcher on Tuesday while Tanner Bibee is making his start in this game on Wednesday. He is 2-8 with a 4.03 ERA this season. His team won 2 of their last 3 games this season with him making an appearance. In his last MLB regular season appearance, he allowed 3 ER, 1 HR, and 2 BB with 7 SO on 4 hits through 5.1 IP against the Houston Astros.

The White Sox are entering this series off a loss and got swept in their 3-game series against the Detroit Tigers 3-0 in their last series. They enter this game with a 40-37 record overall and have a home record of 25-12. This is the 3rd game of a 3-game series with the Guardians on Wednesday with the 2nd game of this series still to be played on Tuesday. The White Sox won the 1st game of this series on Monday. Their offense ranks 10th in the MLB with a .729 OPS. Sean Burke is their starting pitcher on Tuesday while Erick Fedde is making his start in this game on Wednesday. He is 2-6 with a 4.46 ERA this season. His team won 4 of their last 5 games this season with him making an appearance. In his last MLB regular season start, he allowed 2 earned runs, 0 homers, and 1 walk with 4 strikeouts on 4 hits through 4.2 innings pitched against the Detroit Tigers.

The current betting odds have the White Sox listed as a slight underdog in this game according to Draftkings Sportsbook. The White Sox have looked good in their games this season with their 40-37 record overall which has them right near the top of the AL Central. They have looked great in their own ballpark too with their 25-12 home record this season. Meanwhile, the Guardians have looked good in their games this season with their 41-38 record overall which has them right at the top of the AL Central. They have been a good road team too with their 22-21 road record this year. Both of these teams are 4-6 in their last 10 games respectively and haven't looked great lately, but the White Sox took the 1st game of this series and they have the much better offense in this series. The Guardians are going with Bibee in this one and he hasn't looked good this season. He is 2-8 with a 4.03 ERA and he has been giving up a lot of runs all year. His team has had more success with him lately, winning 2 of their last 3 games with him starting, but he did give up 3 earned runs in his last start and that has been a common theme for him. The White Sox are going with Fedde in this one and he hasn't looked good this season either. He is 2-6 with a 4.46 ERA, but lately he hasn't been giving up as many runs and the team has had a lot more success too. They have won 4 of their last 5 games now with him starting and he only gave up 2 earned runs in his last appearance which is starting to become a common theme for him. Look for him to continue to improve at home where the White Sox have looked like one of the best teams in the league this season, and they do have the better offense to take advantage of this pitching matchup. The best way to place a bet here is on the White Sox to win this game. 

Guardians White Sox Prediction:  Our MLB Pick for Wednesday, June 24, 2026 (2:10 pm ET start time) is White Sox 5 Guardians 4.

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Cleveland Guardians: 226-189 (+34.4 units) on the moneyline in all games. 108-102 (+22.8 units) on the moneyline in road games. 130-78 (+23.2 units) on the moneyline as a favorite of -110 or higher. 14-5 OVER vs. good power teams - averaging 1.25 or more HR's/game.

Chicago White Sox: 141-260 (-59.4 units) on the moneyline in all games. 81-118 (-12.6 units) on the moneyline in home games. 120-246 (-63.1 units) on the moneyline as an underdog of +100 or higher. 25-17 OVER as an underdog of +100 to +150.

Cleveland Guardians:  C. DeLauter (RF) Ten Day IL - Rib. A. Martinez (LF) Ten Day IL - Foot. J. Ramirez (3B) Ten Day IL - Hand.

Chicago White Sox:  E. Pereira (RF) Seven Day IL - Concussion. T. Gilbert (RP) Fifteen Day IL - Shoulder. A. Hays (LF) Sixty Day IL - Calf. M. Murakami (1B) Ten Day IL - Hamstring. J. Leasure (RP) Sixty Day IL - Flexor. N. Schultz (SP) Fifteen Day IL - Knee. T. Murray (LF) Sixty Day IL - Shoulder. P. Berroa (RP) Sixty Day IL - Elbow. B. Baldwin (LF) Sixty Day IL - Elbow. M. Vasil (RP) Sixty Day IL - Elbow. D. Thorpe (SP) Sixty Day IL - Elbow. K. Bush (SP) Sixty Day IL - Elbow.

“It’s never easy [to flush a game like that]. The reality is that we’ve got a game in 20 hours [that] we’ve got to find a way to prepare for. We can't change what happened today. Obviously, we can learn from the good or the bad. Just try to go out as prepared as we can to try to even the series tomorrow.” - Rhys Hoskins after their loss against the White Sox in their game on Monday. 

“They covered a lot of ground. Great for them and those guys are obviously very happy.” - Will Venable after his team’s win against the Guardians in their game on Monday. 

Travis Bazzana (L) 2B

David Fry (R) LF

Brayan Rocchio (S) SS

Rhys Hoskins (R) 1B

Kyle Manzardo (L) DH

Gabriel Arias (R) 3B

Stuart Fairchild (R) RF

Austin Hedges (R) C

Petey Halpin (L) CF

Sam Antonacci (L) LF

Miguel Vargas (R) 1B

Andrew Benintendi (L) DH

Kyle Teel (L) C

Colson Montgomery (L) 3B

Chase Meidroth (R) 2B

Braden Montgomery (S) RF

Tristan Peters (L) CF

Luisangel Acuña (R) SS

Batting Average:  Brayan Rocchio (.275)

Hits:  Brayan Rocchio (69)

Home Runs:  Angel Martínez (11)

RBI:  Chase DeLauter (34)

Stolen Bases:  José Ramírez (24)

Wins:  Gavin Williams (9)

Saves:  Cade Smith (24)

ERA:  Logan Allen (0.00)

Batting Average:  Junior Perez (.333)

Hits:  Chase Meidroth (76)

Home Runs:  Munetaka Murakami (20)

RBI:  Colson Montgomery (45)

Stolen Bases:  Luisangel Acuña (13)

Wins:  Davis Martin (9)

Saves:  Seranthony Domínguez (12)

ERA:  Duncan Davitt (0.00)

Managers:

Cleveland Guardians: Stephen Vogt (3rd season)

Chicago White Sox: Will Venable (2nd season)