Cleveland Guardians vs Chicago White Sox Prediction, Preview and Odds - 06/23/2026

Game Time: 7:40 pm ET, Tuesday, June 23, 2026

Venue:  Rate Field, Chicago, IL

Where to Watch:  MLB TV

DraftKings:  Moneyline odds:  Guardians -115, White Sox -105; Over/Under:  7 runs

Bet365:  Moneyline odds:  Guardians -115, White Sox -105; Over/Under:  7 runs

BetMGM:  Moneyline odds:  Guardians -115, White Sox -105; Over/Under:  7.5 runs

Cleveland Guardians:  41-37 (1st place, AL Central)

Chicago White Sox:  39-37 (2nd place, AL Central)

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Cleveland Guardians:  4-6 last 10

Chicago White Sox:  4-6 last 10

The Guardians are entering this series off a loss and lost their 3-game series against the Houston Astros 2-1 in their last series. They enter this game with a 41-37 record overall and have a road record of 22-20. This is the 2nd game of a 3-game series with the White Sox on Tuesday with the series opener still to be played on Monday. Their offense ranks 28th in the MLB with a .683 OPS. Gavin Williams is their starting pitcher on Monday while Parker Messick is making his start in this game on Tuesday. He is 7-3 with a 2.70 ERA this season. His team lost 3 of their last 4 games this season with him making an appearance. In his last MLB regular season appearance, he allowed 2 ER, 0 HR, and 3 BB with 9 SO on 4 hits through 6 IP against the Milwaukee Brewers.

The White Sox are entering this series off a loss and got swept in their 3-game series against the Detroit Tigers 3-0 in their last series. They enter this game with a 39-37 record overall and have a home record of 24-12. This is the 2nd game of a 3-game series with the Guardians on Tuesday with the 1st game of this series still to be played on Monday. Their offense ranks 13th in the MLB with a .729 OPS. Anthony Kay is their starting pitcher on Monday while Sean Burke is making his start in this game on Tuesday. He is 4-4 with a 3.89 ERA this season. His team won 3 of their last 4 games this season with him making an appearance. In his last MLB regular season start, he allowed 1 earned run, 1 homer, and 1 walk with 8 strikeouts on 5 hits through 7.1 innings pitched against the New York Yankees.

The current betting odds have the White Sox listed as a slight underdog in this game according to Draftkings Sportsbook. The White Sox have looked good in their games this season with their 39-37 record overall which has them right near the top of the AL Central. They have looked great in their own ballpark too with their 24-12 home record this season. Meanwhile, the Guardians have looked good in their games this season with their 41-37 record overall which has them right at the top of the AL Central. They have been a good road team too with their 22-20 road record this year. Both of these teams are 4-6 in their last 10 games respectively and both have been slipping over the last 2 weeks, but the White Sox have looked like a different team at home this season and they are going to have the slight edge in this one. Messick is on the mound for the Guardians in this one and he has looked great this season. He is 7-3 with a 2.70 ERA and he hasn't been giving up many runs all year. He only gave up 2 earned runs in his last start which has been a common theme for him, but lately his team hasn't been having a lot of success with him, now losing 3 of their last 4 games with him starting. The White Sox are going with Burke in this one and he has looked good this season. He is 4-4 with a 3.89 ERA and his team has been having a ton of success with him lately. They have won 3 of their last 4 games with him starting and he is coming off another great start in which he only gave up 1 earned run. Both teams have been declining lately, but the White Sox will be looking to bounce back after getting swept in their last series and they do have the much better offense to help them out here. The best way to place a bet here is on the White Sox to win this game. 

Guardians White Sox Prediction:  Our MLB Pick for Tuesday, June 23, 2026 (7:40 pm ET start time) is White Sox 4 Guardians 3.

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Cleveland Guardians: 226-188 (+35.5 units) on the moneyline in all games. 108-101 (+23.9 units) on the moneyline in road games. 130-78 (+23.2 units) on the moneyline as a favorite of -110 or higher. 13-5 OVER vs. good power teams - averaging 1.25 or more HR's/game.

Chicago White Sox: 140-260 (-60.4 units) on the moneyline in all games. 80-118 (-13.6 units) on the moneyline in home games. 120-246 (-63.1 units) on the moneyline as an underdog of +100 or higher. 25-17 OVER as an underdog of +100 to +150.

Cleveland Guardians:  C. DeLauter (RF) Ten Day IL - Rib. A. Martinez (LF) Ten Day IL - Foot. J. Ramirez (3B) Ten Day IL - Hand.

Chicago White Sox:  E. Pereira (RF) Seven Day IL - Concussion. T. Gilbert (RP) Fifteen Day IL - Shoulder. A. Hays (LF) Sixty Day IL - Calf. M. Murakami (1B) Ten Day IL - Hamstring. J. Leasure (RP) Sixty Day IL - Flexor. N. Schultz (SP) Fifteen Day IL - Knee. K. Teel (C) Sixty Day IL - Hamstring. T. Murray (LF) Sixty Day IL - Shoulder. P. Berroa (RP) Sixty Day IL - Elbow. B. Baldwin (LF) Sixty Day IL - Elbow. M. Vasil (RP) Sixty Day IL - Elbow. D. Thorpe (SP) Sixty Day IL - Elbow. K. Bush (SP) Sixty Day IL - Elbow.

“I watched it back, and I was like, ‘I just threw him a homer, you know? I missed with a really good backdoor cutter, one two, really good pitch up away. It was a good, I mean, it was good sequence before that. We went cutter up away strike, fast ball up away foul ball, I believe, sinker off to set up the back door cutter. And then after that, if I throw a cutter there again, it has to… we have to be doing the same thing, where it's ball to strike, clip in the zone. If not, we got to go spin below or four seam above there; we can't throw the cutter.” - Slade Cecconi after their loss against the Astros in their game on Sunday. 

“Tough play going to the backhand right there. I thought the exchange was OK. Obviously Jones did a nice job getting down the line. Acuña has been so good defensively. If there was anything else he could have done, he would have done it." - Will Venable after his team’s loss against the Tigers in their game on Sunday. 

Travis Bazzana (L) DH

Kyle Manzardo (L) 1B

Brayan Rocchio (S) SS

Gabriel Arias (R) 3B

Daniel Schneemann (L) 2B

Kahlil Watson (L) RF

Steven Kwan (L) LF

Patrick Bailey (S) C

Petey Halpin (L) CF

Sam Antonacci (L) LF

Andrew Benintendi (L) DH

Colson Montgomery (L) 3B

Chase Meidroth (R) 2B

Braden Montgomery (S) RF

Jacob Gonzalez (L) 1B

Edgar Quero (S) C

Tristan Peters (L) CF

Luisangel Acuña (R) SS

Batting Average:  Travis Bazzana (.273)

Hits:  Brayan Rocchio (66)

Home Runs:  Angel Martínez (11)

RBI:  Chase DeLauter (34)

Stolen Bases:  José Ramírez (24)

Wins:  Gavin Williams (9)

Saves:  Cade Smith (24)

ERA:  Logan Allen (0.00)

Batting Average:  Junior Perez (.333)

Hits:  Chase Meidroth (75)

Home Runs:  Munetaka Murakami (20)

RBI:  Colson Montgomery (45)

Stolen Bases:  Luisangel Acuña (12)

Wins:  Davis Martin (9)

Saves:  Seranthony Domínguez (12)

ERA:  Duncan Davitt (0.00)

Managers:

Cleveland Guardians: Stephen Vogt (3rd season)

Chicago White Sox: Will Venable (2nd season)