Cleveland Cavaliers vs Philadelphia 76ers Prediction, Preview and Odds - 01/16/2026

Game Time: 7:00 pm ET, Friday, January 16, 2026

Venue:  Xfinity Mobile Arena, Philadelphia, PA

Where to Watch:  ESPN

DraftKings:  Point Spread:  Cavaliers +1.5, 76ers -1.5; Over/Under:  234.5 points

Bet365:  Point Spread:  Cavaliers +1.5, 76ers -1.5; Over/Under:  234.5 points

BetMGM:  Point Spread:  Cavaliers +1.5, 76ers -1.5; Over/Under:  235.5 points

Cleveland Cavaliers:  23-19 (2nd place, Central Division)

Philadelphia 76ers:  22-17 (4th place, Atlantic Division)

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Cleveland Cavaliers:  6-4 last 10

Philadelphia 76ers:  6-4 last 10

The Cavaliers are entering this game with a 23-19 record overall this season and they are 9-9 in their road games this season where they will be in this game. They are entering this game off a win against the Philadelphia 76ers. Donovan Mitchell led the team in points in that game with 35 while Darius Garland was next on the team with 20 points. Donovan Mitchell led the team in assists in that game with 9 while Evan Mobley led the team in rebounds with 13. They were 52.6% from the field, 43.5% from 3-point range, and 72.2% from the free throw line with their shots in that game. Their offense is averaging 120 PPG and their defense is allowing their opponents to average 117.5 PPG against them. The Cavaliers have an ATS record of 14-28 this season and their O/U record is 20-22.

The 76ers are entering this game with a 22-18 record overall this season and they are 10-10 in their home games this season where they will be in this game. They are entering this game off a loss against the Cleveland Cavaliers. Joel Embiid led the team in points in that game with 20 while Paul George was next on the team with 17 points. Paul George, Joel Embiid, and Trendon Watford each led the team in assists in that game with 4 while Andre Drummond led the team in rebounds with 9. They were 40.4% from the field, 27.9% from 3-point range, and 88.5% from the free throw line with their shots in that game. Their offense is averaging 116.8 PPG and their defense is allowing their opponents to average 115.6 PPG against them. The 76ers have an ATS record of 23-16 this season and their O/U record is 21-18.

The current betting odds have the 76ers listed as a 1.5 point favorite in this game according to Draftkings Sportsbook. The 76ers have looked good in their games this season with their 22-18 record overall which has them in the top half of the East. They haven't looked great on their home court though with their 10-10 home record this year. Meanwhile, the Cavaliers have looked good in their games this season with their 23-19 record overall which has them in the top half of the East. They haven't been a great road team though with their 9-9 road record this season. The Cavaliers are 6-4 in their last 10 games and they have looked better lately, but they have still been really up and down all season and have taken a big step back from where they were last season with one of the best records in the entire NBA. They are off a big win over the 76ers in their last one and embarrassed the 76ers on their own floor, but the 76ers aren't going to take that loss lightly with another home game against the Cavs on deck. The 76ers are also 6-4 in their last 10 games so they have looked good lately, and they have improved a lot from being one of the worst teams in the East last season. They have been healthy lately which has led to more success, and their draft pick has had a big impact too. The Cavaliers may have just beaten the 76ers in their own building, but the 76ers will be looking to bounce back with some revenge in a big way here, and the Cavaliers are still one of the worst teams in the NBA against the spread this season. The best way to place a bet here is on the 76ers to cover the spread in this game. 

Cavaliers 76ers Prediction:  Our NBA Pick for Friday, January 16, 2026 (7:00 pm ET start time) is 76ers 121 Cavaliers 114.

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Cleveland Cavaliers: 46-35 ATS versus good offensive teams - scoring 116+ points/game. 17-10 ATS on the road against Atlantic division opponents. 12-6 OVER off a road blowout win by 20 points or more. 37-18 OVER when playing against a marginal winning team (Win Pct. 51% to 60%).

Philadelphia 76ers: 12-22 ATS as a home favorite of 6 points or less. 5-10 ATS after a blowout loss by 20 points or more. 29-21 OVER when playing against a marginal winning team (Win Pct. 51% to 60%). 41-29 OVER versus good offensive teams - scoring 116+ points/game.

Cleveland Cavaliers:  S. Merrill (SG) Day To Day - Hand. D. Garland (PG) Day To Day - Foot. D. Wade (PF) Day To Day - Knee. M. Strus (SF) Out - Foot.

Philadelphia 76ers:  D. Barlow (PF) Day To Day - Back.

“He was hooping. He was getting downhill. Creating, setting the tone. Obviously, there’s concern, always, right? That’s my brother. But in the same token, it’s like, all right, let’s keep moving.” - Donovan Mitchell on Darius Garland after their win against the 76ers in their game on Wednesday.

"Well, obviously, they had a lot more energy than we did, for whatever reason. Just every facet of the game, they took it to us. Faster up the floor, faster to the basket, faster to the offensive rebounds like crazy early in the game and we only had a couple of small segments where we actually played a little better. A little bit through the second and then kind of gave it all back. We had the ball rolling out a chance to cut that whole thing down to five with about four minutes to go, then go down into halftime down 13. Then, even in the stretch when we were way down and cut it back to 15, there was still plenty of time left at that point, and then we just again, lost all our energy and physicality." - Nick Nurse after his team’s loss against the Cavaliers in their game on Wednesday.

PG Darius Garland

SG Donovan Mitchell

SF Jaylon Tyson

PF Evan Mobley

C Jarrett Allen

PG Tyrese Maxey

SG VJ Edgecombe

SF Paul George

PF Dominick Barlow

C Joel Embiid

PPG: Donovan Mitchell (29.7)

APG: Darius Garland (6.9)

Reb/G: Evan Mobley (8.7)

PPG: Tyrese Maxey (30.5)

APG: Tyrese Maxey (6.6)

Reb/G: Andre Drummond (8.8)

Coaches:

Cleveland Cavaliers: Kenny Atkinson (2nd season)

Philadelphia 76ers: Nick Nurse (3rd season)