Cleveland Cavaliers vs Boston Celtics Prediction, Preview and Odds - 10/29/2025

 

Game Time: 7:00 pm ET, Wednesday, October 29, 2025

Venue:  TD Garden, Boston, MA

Where to Watch:  ESPN

DraftKings:  Point Spread:  Cavaliers -3.5, Celtics +3.5; Over/Under:  231.5 points

Bet365:  Point Spread:  Cavaliers -4.5, Celtics +4.5; Over/Under:  232.5 points

BetMGM:  Point Spread:  Cavaliers -4.5, Celtics +4.5; Over/Under:  232.5 points

Cleveland Cavaliers:  3-1 (2nd place, Central Division)

Boston Celtics:  1-3 (4th place, Atlantic Division)

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Cleveland Cavaliers:  3-1 last 4

Boston Celtics:  1-3 last 4

The Cavaliers are entering this game with a 3-1 record overall this season and they are 2-1 in their road games this season where they will be in this game. They are entering this game on a 3 game winning streak with wins coming against the Brooklyn Nets, the Milwaukee Bucks, and the Detroit Pistons. Donovan Mitchell led the team in points in that game with 35 while Jarrett Allen was next on the team with 20 points. De'Andre Hunter led the team in assists in that game with 6 while Evan Mobley led the team in rebounds with 11. They were 45.9% from the field, 31.4% from 3-point range, and 77.1% from the free throw line with their shots in that game. Their offense is averaging 119 PPG and their defense is allowing their opponents to average 112.8 PPG against them. The Cavaliers have an ATS record of 1-3 this season and their O/U record is 2-2.

The Celtics are entering this game with a 1-3 record overall this season and they are 0-1 in their home games this season where they will be in this game. They are entering this game off a win against the New Orleans Pelicans. Anfernee Simons led the team in points in that game with 25 while Payton Pritchard was next on the team with 18 points. Payton Pritchard led the team in assists in that game with 8 while Neemias Queta led the team in rebounds with 11. They were 48.4% from the field, 34% from 3-point range, and 80% from the free throw line with their shots in that game. Their offense is averaging 111.5 PPG and their defense is allowing their opponents to average 107.8 PPG against them. The Celtics have an ATS record of 1-3 this season and their O/U record is 2-2.

The current betting odds have the Cavaliers listed as a 3.5 point favorite in this game according to Draftkings Sportsbook. The Cavaliers have looked really good in their games this season with their 3-1 record overall which has them right near the top of the East. They have been a good road team too with their 2-1 road record so far. Meanwhile, the Celtics haven't looked great in their games this season with their 1-3 record overall which has them right near the bottom of the East. They also have a 0-1 home record this season. They are off their first win of the season in their last one, beating up on a bad Pelicans team, but they lost 3 games in a row to open up the season and they have been struggling with this new look team. They are without Jayson Tatum this season due to injury and that is a huge blow to the team, but they also lost some of their talent in the off-season too. This isn't anywhere near the same team that won the NBA Championship just 2 seasons ago. The Cavaliers were one of the best teams in the NBA last season though and after losing their season opener to the Knicks, they have been starting to roll again. They have won 3 games in a row now and have a ton of momentum on their side. The Cavaliers are just a much better team this season and they are going to continue rolling against this struggling Celtics team. The best way to place a bet here is on the Cavaliers to cover the spread in this game. 

Cavaliers Celtics Prediction:  Our NBA Pick for Wednesday, October 29, 2025 (7:00 pm ET start time) is Cavaliers 115 Celtics 105.

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Cleveland Cavaliers: 30-16 ATS versus good teams - outscoring their opponents by 3+ points/game. 9-4 ATS on the road when playing against a bad team (Win Pct. 25% to 40%). 15-8 ATS on the road against Atlantic division opponents. 11-5 OVER off a road blowout win by 20 points or more. 30-18 OVER versus good teams - outscoring their opponents by 3+ points/game.

Boston Celtics: 17-28 ATS against Central division opponents. 18-26 ATS after a blowout win by 20 points or more. 2-11 ATS when playing against a top-level team (Win Pct. > 70%). 15-9 OVER after playing 3 consecutive road games. 6-1 OVER at home when playing against a top-level team (Win Pct. > 70%). 

Cleveland Cavaliers:  L. Ball (PG) Day To Day - Rest. S. Merrill (SG) Day To Day - Hip. D. Garland (PG) Out - Toe. M. Strus (SF) Out - Foot.

Boston Celtics:  J. Tatum (PF) Out - Achilles.

“First team All-NBA. I don't know why people don't talk about him more. Probably because he's no controversy, low key, humble, does that equal underrated because of the personality? I don't know.” - Kenny Atkinson on Donovan Mitchell.

"It’s going to take some time. We lost four All-Stars from last season between Al (Horford), Jrue (Holiday), Kristaps (Porzingis) and JT (Jayson Tatum) being out. And Luke (Kornet) is an All-Star in all of our hearts. We didn’t lose one guy -- we lost five." - Jaylen Brown after their win against the Pelicans in their game on Monday.

PG Lonzo Ball

SG Donovan Mitchell

SF De'Andre Hunter

PF Evan Mobley

C Jarrett Allen

PG Derrick White

SG Payton Pritchard

SF Josh Minott

PF Jaylen Brown

C Neemias Queta

PPG: Donovan Mitchell (31.3)

APG: Lonzo Ball (6.3)

Reb/G: Evan Mobley (8.8)

PPG: Jaylen Brown (29.7)

APG: Payton Pritchard (4)

Reb/G: Neemias Queta (7)

Coaches:

Cleveland Cavaliers: Kenny Atkinson (2nd season)

Boston Celtics: Joe Mazzulla (4th season)