Clemson Tigers vs Louisville Cardinals Prediction, Picks and Game Preview - 11/14/2025

Game Time: 7:30 pm ET, Friday, November 14, 2025

Venue:  L&N Federal Credit Union Stadium, Louisville, KY

Where to Watch:  ESPN

DraftKings:  Point Spread:  Clemson +3, Louisville -3; Over/Under:  49.5 points

Bet365:  Point Spread:  Clemson +3, Louisville -3; Over/Under:  49.5 points

BetMGM:  Point Spread:  Clemson +3, Louisville -3; Over/Under:  49.5 points

Clemson Tigers:  4-5 (3-4) (10th place, ACC)

Louisville Cardinals:  7-2 (4-2) (6th place, ACC)

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Clemson Tigers:  won their last game at home against the Florida State Seminoles 24-10.

Louisville Cardinals:  lost their last game at home against the California Golden Bears 29-26 in overtime.

Clemson is entering this game with a 4-5 record overall and they have a 3-4 record in their conference games too. They are 2-4 in their home games, 2-1 in their road games, and they are also 0-0 in their neutral site games this season, but they will be on the road for this game. They won their last game against Florida State 24-10. Cade Klubnik was the starting QB and he completed 20/27 passes for 221 passing yards, 1 touchdown, and 0 interceptions. Adam Randall led the team in rushing yards with 48. Antonio Williams led the receivers with 62 receiving yards on 6 receptions and 1 TD. Ashton Hampton led the defense in that game with 6 solo tackles and 3 assisted tackles while Avieon Terrell led the defense in sacks with 1. Ricardo Jones came away with the only interception for them in that one.

 

 

 

Louisville is entering this game with a 7-2 record overall and they have a 4-2 record in their conference games too. They are 4-2 in their home games, 3-0 in their road games, and they are also 0-0 in their neutral site games this season, but they will be at home for this game. They lost their last game against California 29-26 in OT. Miller Moss was the starting QB and he completed 20/38 passes for 203 passing yards, 0 touchdowns, and 1 interception. Keyjuan Brown led the team in rushing yards with 136. Caullin Lacy led the receivers with 60 receiving yards on 4 receptions. Clev Lubin led the defense in that game with 9 solo tackles and 1 assisted tackle while Wesley Bailey, AJ Green, and Jordan Guerad each led the defense in sacks with 1. No one on the defense came away with an interception for them in that one.

The current betting odds have Louisville listed as a 3 point favorite in this game according to Draftkings Sportsbook. Louisville has looked really good in their games this season with their 7-2 record overall and their 4-2 conference record which has them right near the top of the ACC. They are off a 29-26 loss at home to California in their last one and that was a bad loss for them to take, but they are still in the ACC Championship hunt and will be looking to bounce back here. Meanwhile, Clemson hasn't looked great in their games this season with their 4-5 record overall and their 3-4 conference record which has them in the bottom half of the ACC. They are off a nice 24-10 win over Florida State in their last one, but Florida State hasn't looked that good lately as their season has taken a turn for the worst. Clemson has been really up and down this year as they have been able to beat up on bad teams in the conference, but they have struggled when they have had to play against the top teams. Their offense hasn't looked great for a lot of the season either. This Louisville defense hasn't looked great at times, but their offense has been rolling all season, even in their 2 losses, and they are going to be able to put up points at home against this Clemson defense that has struggled against better offenses. Clemson hasn't looked like the team they were supposed to be this season, but Louisville will be looking to bounce back at home as they need to run the table now and this is still a big win for them to get. The best way to place a bet here is on Louisville to cover the spread in this game. 

Clemson Louisville Prediction:  Our NCAAF Pick for Friday, November 14, 2025 (7:30 pm ET start time) is Louisville 34 Clemson 24.

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Clemson Tigers: 5-9 ATS off a win against a conference rival. 2-9 ATS after allowing 14 points or less last game. 3-6 ATS after a game with a turnover margin of +2 or better. 10-2 UNDER in road lined games. 6-1 UNDER in a road game where the total is between 49.5 and 56. 9-1 UNDER after a 2 game home stand.

Louisville Cardinals: 30-20 ATS in a home game where the total is between 49.5 and 56. 19-12 ATS off an upset loss as a home favorite. 25-10 UNDER as a home favorite of 7 points or less. 16-5 UNDER off an upset loss as a home favorite. 23-11 UNDER after a loss by 6 or less points.

Clemson Tigers:  L. Anderson (LB) Questionable - Undisclosed. E. Thurmon (OG) Questionable - Undisclosed. M. Williams Lee (DL) Questionable - Undisclosed. B. Wilkes (LB) Questionable - Undisclosed. A. Mason (DL) Questionable - Undisclosed. A. Watford (DL) Questionable - Undisclosed. J. Haynes (RB) Questionable - Knee. B. Wesco Jr. (WR) Out - Head. E. Ware (OG) Out - Shoulder. J. Green (RB) Out - Foot.

Louisville Cardinals:  T. Carter (LB) Questionable - Undisclosed. J. Agu (CB) Questionable - Undisclosed. I. Brown (RB) Questionable - Undisclosed. S. Clark (LB) Questionable - Ankle. T. Folmar (OG) Questionable - Undisclosed. S. Gates (RB) Questionable - Undisclosed. J. Wilder (RB) Questionable - Undisclosed. T. Egan (QB) Questionable - Undisclosed.

“I loved their effort, I loved their toughness, I loved their stick-to-it-ness.” - Dabo Swinney after his team’s win against FSU in their last game. 

“Disappointing loss. This one stings and hurts, it’s supposed to. We’ve got a lot of things that we got to, that I can go back and work on and find a way to get better.” - Jeff Brohm after his team’s loss against Cal in their last game. 

WR Moore, T.J. 

WR Turner, Cole

WR Williams, Antonio

TE Patt-Henry, Olsen

QB Klubnik, Cade

RB Randall, Adam

WR Hurry, TreyShun

WR Bell, Chris

WR Lacy, Caullin

TE Kurisky, Nate

QB Moss, Miller

RB Brown, Isaac

Passing: Cade Klubnik (2,136)

Rushing: Adam Randall (570)

Receiving: Bryant Wesco Jr. (537)

Touchdowns: Adam Randall (9)

Passing: Miller Moss (2,132)

Rushing: Isaac Brown (782)

Receiving: Chris Bell (792)

Touchdowns: Chris Bell (6)

Coaches:

Clemson Tigers: Dabo Swinney (18th season)

Louisville Cardinals: Jeff Brohm (3rd season)