Clemson Tigers vs Louisville Cardinals Prediction, Picks and Game Preview - 11/06/2021

by Amedeus Mastrangelo

Game Time: 7:30 pm ET, Saturday, November 6, 2021
Venue:  Cardinal Stadium, Louisville, KY
Where to Watch:  ACC Network

 

Opening Odds at USA Sportsbooks

DraftKings:  Point Spread:  Clemson -4, Louisville +4; Over/Under:  46.5 points
Bet365:  Point Spread:  Clemson -4, Louisville +4; Over/Under:  47.5 points
BetMGM:  Point Spread:  Clemson -4, Louisville +4; Over/Under:  47.5 points
 

Season Record

Clemson Tigers:  5-3 (3rd place, ACC Atlantic)
Louisville Cardinals:  4-4 (4th place, ACC Atlantic)
 
Do not miss out on our expert handicapper analysis! Ben Burns is on a RUN of 29-12 L41 (10*) PLAYS! Make sure you check out his picks and many more from the expert handicappers featured in the Shop Picks section.

 

Clemson Tigers vs Louisville Cardinals Preview and Analysis

 
Recent Form
Clemson Tigers:  won at home on Oct. 30 against the Florida State Seminoles 30-20.
Louisville Cardinals:  lost on the road on Oct. 30 against the North Carolina State Wolfpack 28-13.
 
 
 

Clemson Tigers Analysis

Clemson is coming into this college football game with a 5-3 record overall and they are 1-2 in their road games this season where they will be in this game on Saturday afternoon. This will be their 7th conference matchup of the year in their NCAA division and they are not in the best position right now with a 4-2 record in their conference games this season. They have won 3 of their last 4 games and are coming into this one off of a win against FSU. DJ Uiagalelei did not play the best in that game as he completed 19/31 passes for 189 yards, 1 touchdown and 1 interception. Will Shipley had a nice day as he led the team in rushing with 128 yards and 2 touchdowns on 25 carries. Justyn Ross led the receivers with 85 yards on 6 receptions while Joseph Ngata had 52 yards on 3 receptions. Trenton Simpson led the defense in that game with 5 solo tackles and 1 assisted one along with 1 sack as well. Myles Murphy led the defense in sacks in that game with 2.5 while no one on the defense was able to come away with an interception in that one. They have scored 170 points in their 8 games this season averaging 21.3 PPG and they have allowed their opponents to score 122 points against them allowing 15.3 PPG. Their offense is averaging 330.6 YPG while their defense is allowing 326.9 YPG.
 
 

Louisville Cardinals Analysis

Louisville is coming into this game with a 4-4 record overall and they are 3-1 in their home games this college football season where they will be in this game. This will be the 6th conference matchup on their Atlantic Coast Conference schedule this year and they are not in a good position with a 2-3 record in their conference games this season. They have lost 3 of their last 4 games and they are coming into this one off of a loss in their last game. Malik Cunningham did not play his best in that game as he completed 11/28 passes for 219 yards, 1 touchdown and 1 interception. He also led the team in rushing with 76 yards on 18 carries while Jalen Mitchell was right behind him with 69 yards on 13 carries. Jordan Watkins led the receivers with 83 yards and 1 touchdown on 2 receptions while Justin Marshall had 66 yards on 3 receptions. Dorian Jones led the defense in that game with 5 solo tackles and 4 assisted ones. C.J. Avery and Marvin Dallas both combined for the only sack in that game while no one on the defense was able to come up with an interception for them in that one. They have scored 235 points in their 8 games this season averaging 29.4 PPG and they have allowed their opponents to score 217 points against them allowing 27.1 PPG. The Louisville offense is averaging 448.8 YPG while their defense is allowing 416.5 YPG.
 

 

Clemson vs Louisville Prediction

Louisville is coming into this game as a 4 point underdog with the current betting odds according to Draftkings Sportsbook. Clemson has not looked right all season with 3 losses already and even in the game they are winning they are by a very slim margin. Louisville started their season great and have dropped off a bit in their last few games but they are not getting blown out in their games. Louisville has quite a few losses that were very close games, losing by a field goal or less, or else their season could look very different right now. Clemson does not even have a winning record on the road this season so the best bet to place here is on Louisville to cover the spread here at home as they have a chance to even win this game.
 
Clemson Louisville Prediction:  Our NCAAF Pick for Saturday, November 6, 2021 (7:30 pm ET start local time) is Louisville 24 Clemson 20.
Don't miss our champion handicappers free picks, best bets, and expert picks today.  And if you enjoyed this Clemson Tigers Louisville Cardinals prediction, be sure to drop by every day for our weekly NCAAF and NFL predictions and previews.
 

NCAAF Betting Trends

 
Clemson Tigers: 185-171 ATS in all games. 43-38 ATS when the total is between 42.5 and 49. 72-67 ATS in road games. 132-110 ATS against conference opponents.
Louisville Cardinals: 169-177 ATS in all games. 60-64 ATS as an underdog. 17-23 ATS as a home underdog. 77-93 ATS in home games. 94-105 ATS against conference opponents.
 

Key Injuries

 
Clemson Tigers:  P. Mafah (RB) Ques Sat - Undisclosed injury. M. Trotter (OL) Ques Sat - Undisclosed injury. J. Charleston (S) Ques Sat - Undisclosed injury.
Louisville Cardinals:  K. Clark (CB) Ques Sat - Leg injury. B. Smith (WR) out for season - Knee injury. M. Montgomery (LB) out for season - Knee injury.
 

Notable Quotes

 
"It was good to show everybody else he's got the heart of a champion." - Tony Elliott on Will Shipley after his performance in their win over FSU.
 
 
"In the fourth quarter, we just didn't get anything going. We just didn't get any rhythm." - Head coach Scott Satterfield on his team’s loss to NC State in their last game.
 
 

Starting Lineups

 
Clemson Tigers
WR Ngata, Joseph 
WR Williams, E.J. 
WR Ross, Justyn 
TE Allen, Davis  
QB Uiagalelei, D.J. 
RB Pace, Kobe 
 
Louisville Cardinals
WR Marshall, Justin 
WR Jordan Watkins
WR Johnson, Josh 
TE Melton, Dez 
HB Marshon Ford 
QB Cunningham, Malik 
RB Jalen Mitchell 
 

Statistical Leaders

 
Clemson Tigers
Passing: D. Uiagalelei (1291)
Rushing:  W. Shipley (391)
Receiving: J. Ross (426)
Touchdowns: W. Shipley (7)
 
Louisville Cardinals
Passing: M. Cunningham (1903)
Rushing: M. Cunningham (556)
Receiving: J. Watkins (377)
Touchdowns: M. Cunningham (13)
 
Coaches:
Clemson Tigers: Dabo Swinney (14th season)
Louisville Cardinals: Scott Satterfield (3rd season)


Amedeus Mastrangelo

About the Author:

Amedeus Mastrangelo has been heavily wagering on all sports for years and plays just about everything, including sides, totals, favorites, underdogs, against the spread, alternative spreads, first half, second half, player props, and futures. The bottom line is, if Mastrangelo can see an edge in any way shape or form, then he's going to take advantage.

All photographic images used for editorial content have been licensed from the Associated Press.

© 2021 Al McMordie's BigAl.com. All Rights Reserved.