Cincinnati Reds vs St Louis Cardinals Prediction, Preview and Odds - 06/06/2026

Game Time: 2:15 pm ET, Saturday, June 6, 2026

Venue:  Busch Stadium, St. Louis, MO

Where to Watch:  MLB TV

DraftKings:  Moneyline odds:  Reds +109, Cardinals -131; Over/Under:  9.5 runs

Bet365:  Moneyline odds:  Reds +110, Cardinals -130; Over/Under:  9.5 runs

BetMGM:  Moneyline odds:  Reds +110, Cardinals -130; Over/Under:  9.5 runs

Cincinnati Reds:  31-30 (5th place, NL Central)

St Louis Cardinals:  32-28 (3rd place, NL Central)

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Cincinnati Reds:  5-5 last 10

St Louis Cardinals:  3-7 last 10

The Reds are entering this series off a loss and lost their 3-game series against the Kansas City Royals 2-1 in their last series. They enter this game with a 31-30 record overall and have a road record of 15-14. This is the 2nd game of a 3-game series with the Cardinals on Saturday with the series opener still to be played on Friday. Their offense ranks 14th in the MLB with a .707 OPS. Brady Singer is their starting pitcher on Friday while Nick Lodolo is making his start in this game on Saturday. He is 2-1 with a 5.20 ERA this season. His team won their last 2 straight games this season with him making an appearance. In his last MLB regular season appearance, he allowed 3 ER, 2 HR, and 4 BB with 4 SO on 5 hits through 6.2 IP against the Atlanta Braves.

The Cardinals are entering this series off a win and lost their 3-game series against the Texas Rangers 2-1 in their last series. They enter this game with a 32-28 record overall and have a home record of 16-16. This is the 2nd game of a 3-game series with the Reds on Saturday with the 1st game of this series still to be played on Friday. Their offense ranks 21st in the MLB with a .701 OPS. Kyle Leahy is their starting pitcher on Friday while Matthew Liberatore is making his start in this game on Saturday. He is 3-3 with a 4.35 ERA this season. His team won 2 of their last 3 games this season with him making an appearance. In his last MLB regular season start, he allowed 0 earned runs, 0 homers, and 1 walk with 4 strikeouts on 3 hits through 5.1 innings pitched against the Chicago Cubs.

The current betting odds have the Cardinals listed as a slight favorite in this game according to Draftkings Sportsbook. The Cardinals have looked good in their games this season with their 32-28 record overall which has them right near the top of the NL Central. They haven't looked great in their own ballpark though with their 16-16 home record this season. Meanwhile, the Reds have looked good in their games this season with their 31-30 record overall, but that record has them right at the bottom of the NL Central. They have been a good road team too with their 15-14 road record this year. The Cardinals are 3-7 in their last 10 games and they haven't looked great lately, but they will be looking to bounce back at home in this important divisional series. The Reds are 5-5 in their last 10 games, but they have been really up and down lately, and this is a pitching matchup that the Cardinals can take advantage of. The Cardinals are going with Liberatore in this one and he hasn't looked great this season. He is 3-3 with a 4.35 ERA, but lately he has looked a lot better with less runs allowed. He is coming off a great start in which he gave up no runs and even his team has been having more success now, winning 2 of their last 3 games with him starting. The Reds are going with Lodolo in this one and he hasn't looked good this season. He is 2-1 with a 5.20 ERA and he has been giving up quite a few runs all year. His team has won 2 games in a row now with him starting, but that hasn't been a common theme for them with Lodolo starting, and he did give up 3 earned runs in his last start which has basically been an average night for him. Neither offense has been great lately with the runs being put up on each side, so look for the Cardinals to edge this one out at home with the better pitching matchup. The best way to place a bet here is on the Cardinals to win this game. 

Reds Cardinals Prediction:  Our MLB Pick for Saturday, June 6, 2026 (2:15 pm ET start time) is Cardinals 5 Reds 3.

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Cincinnati Reds: 44-58 (-5.1 units) on the moneyline as a road underdog of +100 to +150. 51-64 (-14.3 units) on the moneyline against division opponents. 48-56 (-8.7 units) on the moneyline against left-handed starters. 21-13 OVER on the road when the total is 9 to 9.5.

St Louis Cardinals: 118-107 (+12.3 units) on the moneyline when the money line is +125 to -125. 57-47 (+9.5 units) on the moneyline against left-handed starters. 88-92 (+8.1 units) on the moneyline when playing against a team with a winning record. 6-3 OVER vs. teams outscored by opp by 0.5 or more runs/game on the season.

Cincinnati Reds:  E. De La Cruz (SS) Ten Day IL - Hamstring. P. Johnson (RP) Fifteen Day IL - Elbow. G. Ashcraft (RP) Sixty Day IL - Forearm. R. Lowder (SP) Fifteen Day IL - Shoulder. K. Hayes (3B) Ten Day IL - Back. J. Trevino (C) Ten Day IL - Hamstring. E. Pagan (RP) Fifteen Day IL - Hamstring. B. Williamson (SP) Sixty Day IL - Shoulder. H. Greene (SP) Sixty Day IL - Elbow.

St Louis Cardinals:  N. Church (LF) Ten Day IL - Lower-body. R. Urias (3B) Ten Day IL - Elbow. L. Nootbaar (LF) Sixty Day IL - Heels.

"We’re at a point where we need some stability so much. He’s the guy. We're going to have to figure that out. Do we pick our spots? We tried to do that before, but with everybody going down (with injuries), that’s been a little more difficult." - Terry Francona on Tony Santillan after his team’s loss against the Royals in their game on Wednesday. 

“This is a guy, when you think about (Saggese) and what he's been able to do — early on, he showed some real hitability. And getting him out there more often in some way is going to be helpful to him. But tonight was a really good swing from him.” - Oliver Marmol after his team’s win against the Rangers in their game on Wednesday. 

Blake Dunn (R) CF

JJ Bleday (L) LF

Sal Stewart (R) 1B

Nathaniel Lowe (L) DH

Eugenio Suárez (R) 3B

Spencer Steer (R) 2B

Will Benson (L) RF

Tyler Stephenson (R) C

Matt McLain (R) SS

Masyn Winn (R) SS

Iván Herrera (R) C

Jordan Walker (R) RF

Nelson Velázquez (R) DH

Alec Burleson (L) 1B

José Fermín (R) LF

Nolan Gorman (L) 3B

Thomas Saggese (R) 2B

Victor Scott II (L) CF

Batting Average:  JJ Bleday (.289)

Hits:  Elly De La Cruz (65)

Home Runs:  Sal Stewart (12)

RBI:  Elly De La Cruz (37)

Stolen Bases:  Sal Stewart (10)

Wins:  Chase Burns (7)

Saves:  Emilio Pagán (6)

ERA:  Caleb Ferguson (0.00)

Batting Average:  Nelson Velázquez (.462)

Hits:  Jordan Walker (66)

Home Runs:  Jordan Walker (15)

RBI:  Jordan Walker (44)

Stolen Bases:  Jordan Walker (8)

Wins:  Andre Pallante (6)

Saves:  Riley O'Brien (15)

ERA:  Gordon Graceffo (1.76)

Managers:

Cincinnati Reds: Terry Francona (2nd season)

St Louis Cardinals: Oliver Marmol (5th season)