Cincinnati Reds vs Cleveland Guardians Prediction, Preview and Odds - 06/11/2025

Game Time: 1:10 pm ET, Wednesday, June 11, 2025

Venue:  Progressive Field, Cleveland, OH

Where to Watch:  CLEGUARDIANS.tv

DraftKings:  Moneyline odds:  Reds -108, Guardians -112; Over/Under:  8.5 runs

Bet365:  Moneyline odds:  Reds -110, Guardians -110; Over/Under:  8.5 runs

BetMGM:  Moneyline odds:  Reds -110, Guardians -110; Over/Under:  8.5 runs

Cincinnati Reds:  34-33 (4th place, NL Central)

Cleveland Guardians:  34-31 (3rd place, AL Central)

Do not miss out on our expert handicapper analysis! Sean Murphy is on a HOT STREAK in the MLB on a 33-17-3 MLB RUN for +$11,130 PROFIT! Make sure you check out his picks and many more from the expert handicappers featured in the Shop Picks section.

Cincinnati Reds:  6-4 last 10

Cleveland Guardians:  4-6 last 10

The Reds are entering this series off a win and completed the sweep in their 3-game series against the Arizona Diamondbacks 3-0 in their last series. They enter this game with a 34-33 record overall and have a road record of 16-17. This is the series finale of a 3-game series with the Guardians on Wednesday with the 2nd game still to be played on Tuesday. The Reds won the series opener on Monday. Their offense ranks 10th in the MLB with a .723 OPS. Andrew Abbott is their starting pitcher on Tuesday while Nick Lodolo is making his start in this game on Wednesday. He is 4-4 with a 3.21 ERA this season. His team lost 2 of their last 3 games this season with him making an appearance. In his last MLB regular season start, he allowed 3 ER, 2 HR, and 0 BB with 4 Ks on 5 hits through 6 IP against the Arizona Diamondbacks.

The Guardians are entering this series off a win and lost their 3-game series against the Houston Astros 2-1 in their last series. They enter this game with a 34-31 record overall and have a home record of 18-14. This is the 3rd game of a 3-game series with the Reds on Wednesday with the 2nd game of this series still to be played on Tuesday. The Guardians lost the 1st game of this series on Monday. Their offense ranks 23rd in the MLB with a .683 OPS. Slade Cecconi is their starting pitcher on Tuesday while Logan Allen is making his start in this game on Wednesday. He is 3-4 with a 4.42 ERA this season. His team lost 3 of their last 4 games this season with him making an appearance. In his last MLB regular season start, he allowed 4 earned runs, 1 homer, and 2 BB with 2 strikeouts on 7 hits through 6 innings played against the Houston Astros.

The current betting odds have the Reds listed as a slight underdog in this game according to Draftkings Sportsbook. The Reds haven't looked great in their games this season with their 34-33 record overall which has them right near the bottom of the NL Central. They haven't been a good road team either with their 16-17 road record this year. Meanwhile, the Guardians have looked good in their games this season with their 34-31 record overall which has them right in the middle of the AL Central. They have looked better in their own ballpark too with their 18-14 home record this season. They haven't looked good lately though, going 4-6 in their last 10 games while the Reds are 6-4 in their last 10. The Reds are going with Lodolo in this one and he has looked good in his starts this year. He is 4-4 with a 3.21 ERA and hasn't been giving up many runs in his starts lately. He did give up 3 earned runs in his last start, but he will be looking to have a better start here and the Guardians don't have a strong offense either. The Guardians are also going with Allen in this one and he hasn't looked great lately. He is 3-4 with a 4.42 ERA and he gave up 4 earned runs in his last start too. He has been giving up more runs in his starts lately and the team hasn't been finding success with him on the mound either, losing 3 of the last 4 games he started in. The Reds have had a really good offense lately and this is a pitching matchup that they can take advantage of since they have the more reliable starter here. The best way to place a bet here is on the Reds to win this game. 

Reds Guardians Prediction:  Our MLB Pick for Wednesday, June 11, 2025 (1:10 pm ET start time) is Reds 6 Guardians 4.

Don't miss our champion handicappers free picks, best bets, and expert baseball picks today.  And if you enjoyed this Cincinnati Reds Cleveland Guardians prediction, be sure to drop by every day for our daily MLB projections and previews.

Cincinnati Reds: 108-125 (+18.8 units) on the moneyline as an underdog of +100 or higher. 97-97 (+22.8 units) on the moneyline in road games. 60-53 (+12.5 units) on the moneyline in an inter-league game. 91-60 UNDER in day games.

Cleveland Guardians: 53-60 (-11.8 units) on the moneyline in an inter-league game. 60-61 (-8.7 units) on the moneyline against left-handed starters. 14-26 (-11.3 units) on the moneyline vs. an NL starting pitcher whose WHIP is 1.250 or better. 25-15 UNDER against NL Central opponents.

Cincinnati Reds:  H. Greene (SP) Fifteen Day IL - Groin. R. Lowder (SP) Sixty Day IL - Forearm. A. Hays (LF) Ten Day IL - Foot. C. Spiers (RP) Sixty Day IL - Shoulder. T. Callihan (LF) Sixty Day IL - Forearm. N. Marte (3B) Ten Day IL - Side. J. Candelario (3B) Ten Day IL - Back. B. Williamson (SP) Sixty Day IL - Elbow. J. Aguiar (SP) Sixty Day IL - Elbow.

Cleveland Guardians:  A. Walters (RP) Sixty Day IL - Lat. A. Hedges (C) Seven Day IL - Concussion. B. Lively (SP) Sixty Day IL - Forearm. W. Brennan (RF) Ten Day IL - Forearm. P. Sewald (RP) Fifteen Day IL - Shoulder. S. Bieber (SP) Sixty Day IL - Elbow. E. Sabrowski (RP) Sixty Day IL - Elbow. T. Stephan (RP) Sixty Day IL - Elbow. J. Means (SP) Sixty Day IL - Elbow. S. Hentges (RP) Sixty Day IL - Shoulder.

“I would never say yes, because the minute I do, something will [happen]. Now we’ll try to play good tomorrow. Because if you do that enough, then I think momentum does happen." - Terry Francona after his team’s win against the Guardians in their game on Monday.

"Great to have Lane back in the lineup. He's feeling good. He said he hasn't felt this good in a year. It's really good to have him back. Obviously, he makes the lineup longer, [and he is] one of our best players." - Stephen Vogt after his team’s loss against the Reds in their game on Monday.

TJ Friedl (L) CF

Gavin Lux (L) DH

Elly De La Cruz (S) SS

Christian Encarnacion-Strand (R) 1B

Tyler Stephenson (R) C

Will Benson (L) LF

Santiago Espinal (R) 3B

Jake Fraley (L) RF

Matt McLain (R) 2B

Steven Kwan (L) LF

Lane Thomas (R) CF

José Ramírez (S) 3B

David Fry (R) DH

Carlos Santana (S) 1B

Gabriel Arias (R) SS

Johnathan Rodríguez (R) RF

Bo Naylor (L) C

Angel Martínez (S) 2B

Batting Average:  Austin Wynns (.400)

Hits:  TJ Friedl (71)

Home Runs:  Elly De La Cruz (12)

RBI:  Elly De La Cruz (43)

Stolen Bases:  Elly De La Cruz (19)

Wins:  Brady Singer (6)

Saves:  Emilio Pagán (16)

ERA:  Joe La Sorsa (0.00)

Batting Average:  José Ramírez (.333)

Hits:  José Ramírez (79)

Home Runs:  José Ramírez (12)

RBI:  José Ramírez (32)

Stolen Bases:  José Ramírez (19)

Wins:  Gavin Williams (5)

Saves:  Emmanuel Clase (14)

ERA:  Hunter Gaddis (1.40)

Managers:

Cincinnati Reds: Terry Francona (1st season)

Cleveland Guardians: Stephen Vogt (2nd season)