Cincinnati Reds vs Cleveland Guardians Prediction, Preview and Odds - 06/10/2025

Game Time: 6:40 pm ET, Tuesday, June 10, 2025

Venue:  Progressive Field, Cleveland, OH

Where to Watch:  CLEGUARDIANS.tv

DraftKings:  Moneyline odds:  Reds -110, Guardians -110; Over/Under:  8.5 runs

Bet365:  Moneyline odds:  Reds -110, Guardians -110; Over/Under:  8.5 runs

BetMGM:  Moneyline odds:  Reds -110, Guardians -110; Over/Under:  8.5 runs

Cincinnati Reds:  33-33 (4th place, NL Central)

Cleveland Guardians:  34-30 (3rd place, AL Central)

Do not miss out on our expert handicapper analysis! Sean Murphy is on a HOT STREAK in the MLB on a 31-16-2 MLB RUN for +$10,650 PROFIT! Make sure you check out his picks and many more from the expert handicappers featured in the Shop Picks section.

Cincinnati Reds:  5-5 last 10

Cleveland Guardians:  5-5 last 10

The Reds are entering this series off a win and completed the sweep in their 3-game series against the Arizona Diamondbacks 3-0 in their last series. They enter this game with a 33-33 record overall and have a road record of 15-17. This is the 2nd game of a 3-game series with the Guardians on Tuesday with the series opener still to be played on Monday. Their offense ranks 12th in the MLB with a .717 OPS. Wade Miley is their starting pitcher on Monday while Andrew Abbott is making his start in this game on Tuesday. He is 5-1 with a 2.18 ERA this season. His team won 3 of their last 4 games this season with him making an appearance. In his last MLB regular season start, he allowed 5 ER, 2 HR, and 1 BB with 6 Ks on 7 hits through 6 IP against the Milwaukee Brewers.

The Guardians are entering this series off a win and lost their 3-game series against the Houston Astros 2-1 in their last series. They enter this game with a 34-30 record overall and have a home record of 18-13. This is the 2nd game of a 3-game series with the Reds on Tuesday with the 1st game of this series still to be played on Monday. Their offense ranks 23rd in the MLB with a .683 OPS. Luis Ortiz is their starting pitcher on Monday while Slade Cecconi is making his start in this game on Tuesday. He is 1-2 with a 4.87 ERA this season. His team won 2 of their last 3 games this season with him making an appearance. In his last MLB regular season start, he allowed 2 earned runs, 1 homer, and 2 BB with 3 strikeouts on 5 hits through 5 innings played against the New York Yankees.

The current betting odds have the Reds listed as a pick ‘em in this game according to Draftkings Sportsbook. The Reds haven't looked great in their games this season with their 33-33 record overall which has them right near the bottom of the NL Central. They haven't been a good road team either with their 15-17 road record this year. Meanwhile, the Guardians have looked good in their games this season with their 34-30 record overall which has them right in the middle of the AL Central. They have looked better in their own ballpark too with their 18-13 home record this season. Both of these teams are 5-5 in their last 10 games and haven't looked great lately, but the Guardians did lose their last series while the Reds won theirs and have some momentum on their side now. The Reds also have the much better pitching matchup in this one and they can take advantage of that. Abbott is on the mound for the Reds here and he has been lights out for most of the season. He is 5-1 with a 2.18 ERA and the team has been having success with him on the mound, winning 3 of the last 4 games he started in. He did give up 5 earned runs in his last start, but that hasn't been a common theme for him this season and he will be looking to bounce back in this game. The Guardians are going with Cecconi in this one and he hasn't looked that great this season. He is 1-2 with a 4.87 ERA and he has been giving up quite a few runs in his starts all year. He only gave up 2 earned runs in his last start, but that hasn't been a common theme for him this year and the Reds are coming into this series hot. The best way to place a bet here is on the Reds to win this game. 

Reds Guardians Prediction:  Our MLB Pick for Tuesday, June 10, 2025 (6:40 pm ET start time) is Reds 4 Guardians 1.

Don't miss our champion handicappers free picks, best bets, and expert baseball picks today.  And if you enjoyed this Cincinnati Reds Cleveland Guardians prediction, be sure to drop by every day for our daily MLB projections and previews.

Cincinnati Reds: 107-125 (+17.3 units) on the moneyline as an underdog of +100 or higher. 96-97 (+21.4 units) on the moneyline in road games. 142-134 (+22.8 units) on the moneyline against right-handed starters. 22-16 UNDER against AL Central opponents.

Cleveland Guardians: 53-59 (-10.3 units) on the moneyline in an inter-league game. 60-60 (-7.2 units) on the moneyline against left-handed starters. 14-26 (-11.3 units) on the moneyline vs. an NL starting pitcher whose WHIP is 1.250 or better. 25-14 UNDER against NL Central opponents.

Cincinnati Reds:  H. Greene (SP) Fifteen Day IL - Groin. R. Lowder (SP) Sixty Day IL - Forearm. A. Hays (LF) Ten Day IL - Foot. C. Spiers (RP) Sixty Day IL - Shoulder. T. Callihan (LF) Sixty Day IL - Forearm. N. Marte (3B) Ten Day IL - Side. J. Candelario (3B) Ten Day IL - Back. B. Williamson (SP) Sixty Day IL - Elbow. J. Aguiar (SP) Sixty Day IL - Elbow.

Cleveland Guardians:  A. Walters (RP) Sixty Day IL - Lat. A. Hedges (C) Seven Day IL - Concussion. L. Thomas (CF) Ten Day IL - Foot. B. Lively (SP) Sixty Day IL - Forearm. W. Brennan (RF) Ten Day IL - Forearm. P. Sewald (RP) Fifteen Day IL - Shoulder. S. Bieber (SP) Sixty Day IL - Elbow. E. Sabrowski (RP) Sixty Day IL - Elbow. T. Stephan (RP) Sixty Day IL - Elbow. J. Means (SP) Sixty Day IL - Elbow. S. Hentges (RP) Sixty Day IL - Shoulder.

“Things like that really help. When you’ve got your teammates beating you on the back, telling you, ‘Way to go’, that goes a long way.” - Terry Francona after his team’s win against the Diamondbacks in their game on Sunday.

“Getting in a little ‘Guards Ball’ with the bunt and the throwaway. That looked like us.” - Stephen Vogt after his team’s win against the Astros in their game on Sunday.

TJ Friedl (L) CF

Gavin Lux (L) DH

Elly De La Cruz (S) SS

Christian Encarnacion-Strand (R) 3B

Will Benson (L) LF

Spencer Steer (R) 1B

Jose Trevino (R) C

Jake Fraley (L) RF

Matt McLain (R) 2B

Steven Kwan (L) LF

Angel Martínez (S) CF

José Ramírez (S) 3B

David Fry (R) DH

Carlos Santana (S) 1B

Gabriel Arias (R) SS

Johnathan Rodríguez (R) RF

Bo Naylor (L) C

Will Wilson (R) 2B

Batting Average:  Austin Wynns (.400)

Hits:  TJ Friedl (69)

Home Runs:  Elly De La Cruz (12)

RBI:  Elly De La Cruz (43)

Stolen Bases:  Elly De La Cruz (19)

Wins:  Brady Singer (6)

Saves:  Emilio Pagán (15)

ERA:  Joe La Sorsa (0.00)

Batting Average:  José Ramírez (.333)

Hits:  José Ramírez (78)

Home Runs:  José Ramírez (12)

RBI:  José Ramírez (31)

Stolen Bases:  José Ramírez (18)

Wins:  Gavin Williams (5)

Saves:  Emmanuel Clase (14)

ERA:  Hunter Gaddis (1.40)

Managers:

Cincinnati Reds: Terry Francona (1st season)

Cleveland Guardians: Stephen Vogt (2nd season)