Cincinnati Reds vs Chicago White Sox Prediction, Preview and Odds - 08/13/2026

Game Time: 2:10 pm ET, Thursday, August 13, 2026

Venue:  Rate Field, Chicago, IL

Where to Watch:  MLB TV

DraftKings:  Moneyline odds:  Reds +113, White Sox -136; Over/Under:  8 runs

Bet365:  Moneyline odds:  Reds +115, White Sox -135; Over/Under:  8.5 runs

BetMGM:  Moneyline odds:  Reds +115, White Sox -140; Over/Under:  8 runs

Cincinnati Reds:  57-61 (4th place, NL Central)

Chicago White Sox:  61-57 (1st place, AL Central)

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Cincinnati Reds:  6-4 last 10

Chicago White Sox:  4-6 last 10

The Reds are entering this series off a loss and got swept in their 3-game series against the Washington Nationals 3-0 in their last series. They enter this game with a 57-61 record overall and have a road record of 28-30. This is the series finale of a 3-game series with the White Sox on Thursday with the 2nd game still to be played on Wednesday. The Reds won the series opener on Tuesday. Their offense ranks 23rd in the MLB with a .704 OPS. Rhett Lowder is their starting pitcher on Wednesday while Andrew Abbott is making his start in this game on Thursday. He is 6-7 with a 3.92 ERA this season. His team won 2 of their last 3 games this season with him making an appearance. In his last MLB regular season appearance, he allowed 3 ER, 0 HR, and 2 BB with 4 SO on 7 hits through 6.2 IP against the Athletics.

The White Sox are entering this series off a win and won their 3-game series against the Cleveland Guardians 2-1 in their last series. They enter this game with a 61-57 record overall and have a home record of 36-23. This is the 3rd game of a 3-game series with the Reds on Thursday with the 2nd game of this series still to be played on Wednesday. The White Sox lost the 1st game of this series on Tuesday. Their offense ranks 13th in the MLB with a .722 OPS. Luis Castillo is their starting pitcher on Wednesday while Davis Martin is making his start in this game on Thursday. He is 9-6 with a 4.17 ERA this season. His team won 2 of their last 3 games this season with him making an appearance. In his last MLB regular season start, he allowed 1 earned run, 0 homers, and 1 walk with 1 strikeout on 2 hits through 1 inning pitched against the Cleveland Guardians.

The current betting odds have the Reds listed as an underdog in this game according to Draftkings Sportsbook. The White Sox have looked good in their games this season with their 61-57 record overall which has them right at the top of the AL Central. They have looked great in their own ballpark too with their 36-23 home record this season. Meanwhile, the Reds haven't looked great in their games this season with their 57-61 record overall which has them right at the bottom of the NL Central. They haven't been a good road team either with their 28-30 road record this year. The White Sox have looked a lot better in their home games this season, but lately they haven't been at their best with some pitching troubles, now 4-6 in their last 10 games. The Reds have been fighting to keep themselves in the NL Wild Card race and they are starting to get hot again, now 6-4 in their last 10 games. The Reds are going with Abbott in this one and he has looked good this season. He is 6-7 with a 3.92 ERA and he has looked a lot better lately. He did give up 3 earned runs in his last start, but that hasn't been a common theme for him lately and the team has been having success with him, winning 2 of their last 3 games with him starting. The White Sox are going with Martin in this one and he hasn't looked great this year. He is 9-6 with a 4.17 ERA and was their best starter for a lot of the season, but lately he has been falling apart. The team has still won 2 of their last 3 games with him starting, but he gave up 1 earned run in 1 inning in his last start and he has been giving up a lot more runs over the last month. The White Sox don't have a great bullpen to help him out either, so look for the Reds to take advantage of this pitching matchup. The best way to place a bet here is on the Reds to win this game. 

Reds White Sox Prediction:  Our MLB Pick for Thursday, August 13, 2026 (2:10 pm ET start time) is Reds 7 White Sox 4.

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Cincinnati Reds: 104-118 (+8.2 units) on the moneyline in road games. 74-63 (+15.2 units) on the moneyline in an inter-league game. 166-161 (+11.5 units) on the moneyline against right-handed starters. 11-5 OVER against AL Central opponents.

Chicago White Sox: 11-29 (-14.3 units) on the moneyline against NL Central opponents. 162-280 (-57.2 units) on the moneyline in all games. 92-129 (-13.6 units) on the moneyline in home games. 24-13 OVER against NL Central opponents.

Cincinnati Reds:  B. Dunn (CF) Sixty Day IL - Elbow. H. Greene (SP) Sixty Day IL - Elbow. S. Steer (1B) Ten Day IL - Wrist. T. Santillan (RP) Fifteen Day IL - Oblique. G. Ashcraft (RP) Sixty Day IL - Forearm. B. Williamson (SP) Sixty Day IL - Shoulder.

Chicago White Sox:  C. Meidroth (2B) Day To Day - Wrist. C. Murphy (RP) Fifteen Day IL - Flexor. J. Bart (C) Ten Day IL - Hand. K. Teel (C) Ten Day IL - Ankle. J. Leasure (RP) Sixty Day IL - Flexor. T. Murray (LF) Sixty Day IL - Shoulder. P. Berroa (RP) Sixty Day IL - Elbow. B. Baldwin (LF) Sixty Day IL - Elbow. M. Vasil (RP) Sixty Day IL - Elbow. D. Thorpe (SP) Sixty Day IL - Elbow. K. Bush (SP) Sixty Day IL - Elbow.

“The kid had a great at-bat. Give that kid a ton of credit, but I would also say give Pagán a ton of credit. The saving grace for me is I know Pagán was loving every minute of it.” - Terry Francona after his team’s win against the White Sox in their game on Tuesday. 

“He was awesome. Feel like he one-ups himself every time he goes out there. Really good feel for the slider. Thought he got a ton of swing and miss on it. A good fastball again.” - Will Venable on Sean Burke after his team’s loss against the Reds in their game on Tuesday.

Elly De La Cruz (S) SS

Sal Stewart (R) 1B

JJ Bleday (L) LF

Tyler Stephenson (R) C

Eugenio Suárez (R) DH

Héctor Rodríguez (L) RF

Dane Myers (R) CF

Matt McLain (R) 2B

Ke'Bryan Hayes (R) 3B

Brenton Doyle (R) CF

Munetaka Murakami (L) 1B

Miguel Vargas (R) 3B

Randal Grichuk (R) LF

Braden Montgomery (S) RF

Colson Montgomery (L) DH

Edgar Quero (S) C

Sam Antonacci (L) 2B

Luisangel Acuña (R) SS

Batting Average:  Michael Toglia (.500)

Hits:  Sal Stewart (114)

Home Runs:  Sal Stewart (25)

RBI:  Sal Stewart (87)

Stolen Bases:  Elly De La Cruz (21)

Wins:  Chase Burns (13)

Saves:  Emilio Pagán (14)

ERA:  Chase Burns (2.61)

Batting Average:  Brenton Doyle (.294)

Hits:  Chase Meidroth (114)

Home Runs:  Colson Montgomery (26)

RBI:  Colson Montgomery (68)

Stolen Bases:  Luisangel Acuña (16)

Wins:  Davis Martin (9)

Saves:  Seranthony Domínguez (12)

ERA:  Hagen Smith (0.00)

Managers:

Cincinnati Reds: Terry Francona (2nd season)

Chicago White Sox: Will Venable (2nd season)