Cincinnati Bengals vs Buffalo Bills Prediction, Preview and Odds - 12/07/2025

Game Time: 1:00 pm ET, Sunday, December 7, 2025

Venue:  Highmark Stadium, Orchard Park, NY

Where to Watch:  FOX

DraftKings:  Point Spread:  Bengals +6, Bills -6; Over/Under:  51.5 points

Bet365:  Point Spread:  Bengals +5.5, Bills -5.5; Over/Under:  52.5 points

BetMGM:  Point Spread:  Bengals +6, Bills -6; Over/Under:  52.5 points

Cincinnati Bengals:  4-8 (3rd place, AFC North)

Buffalo Bills:  8-4 (2nd place, AFC East)

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Cincinnati Bengals:  won their last game on the road against the Baltimore Ravens 32-14.

Buffalo Bills:  won their last game on the road against the Pittsburgh Steelers 26-7.

The Bengals are entering this game with a 4-8 record overall and they have a 3-1 record in their divisional games too. They are 2-4 in their home games, 2-4 in their road games, and they are also 0-0 in their neutral site games this season, but they will be on the road for this game. They won their last game against the Baltimore Ravens 32-14. Joe Burrow was the starting QB and he completed 24/46 passes for 261 passing yards, 2 touchdowns, and 0 interceptions. Chase Brown led the team in rushing yards with 78. Ja'Marr Chase led the receivers with 110 receiving yards on 7 receptions. Jordan Battle led the defense in that game with 6 solo tackles and 2 assisted tackles while Joseph Ossai led the defense in sacks with 2. Demetrius Knight Jr. came away with the only interception for them in that one.

 

 

 

The Bills are entering this game with an 8-4 record overall and they have a 2-2 record in their divisional games too. They are 5-1 in their home games, 3-3 in their road games, and they are also 0-0 in their neutral site games this season, but they will be at home for this game. They won their last game against the Pittsburgh Steelers 26-7. Josh Allen was the starting QB and he completed 15/23 passes for 123 passing yards, 1 touchdown, and 1 interception. James Cook led the team in rushing yards with 144. James Cook led the receivers with 33 receiving yards on 3 receptions. Shaq Thompson led the defense in that game with 5 solo tackles and 4 assisted tackles while Joey Bosa led the defense in sacks with 1. Christian Benford came away with the only interception for them in that one.

The current betting odds have the Bills listed as a 6 point favorite in this game according to Draftkings Sportsbook. The Bills have looked good in their games this season with their 8-4 record overall which has them right near the top of the AFC East. They have looked great on their home field too with their 5-1 home record this season. Meanwhile, the Bengals haven't looked good in their games this season with their 4-8 record overall which has them right near the bottom of the AFC North. They haven't been a great road team either with their 2-4 road record this year. They are off a big win over the Ravens in their last one, winning 32-14 with Joe Burrow back, but the Bengals still have a lot of work to do with their playoff chances looking slim. The offense looked great with Burrow back, but the offense hasn't been an issue without him. They still have one of the worst defenses in the NFL and they are going to give up points in this game. The Bills haven't looked great lately, but they are off a 26-7 win over the Steelers in their last one and that win will give them some momentum coming into this one. The Bills have looked a lot better in their home games this year and they have been blowing out a lot of teams in those games. The Bills haven't looked great with their defense this season, but they looked a lot better last week and will play better at home. The best way to place a bet here is on the Bills to cover the spread in this game. 

Bengals Bills Prediction:  Our NFL Pick for Sunday, December 7, 2025 (1:00 pm ET start time) is Bills 31 Bengals 20.

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Cincinnati Bengals: 6-1 ATS in all games where the total is greater than or equal to 49.5. 4-0 ATS after a win by 14 or more points. 9-4 ATS vs. good offensive teams - scoring 24 or more points/game. 27-18 OVER in all games. 10-5 OVER when playing against a good team (Win Pct. 60% to 75%).

Buffalo Bills: 6-11 ATS when playing against a team with a losing record. 0-10 ATS vs. bad defensive teams who give up 24 or more points/game. 0-9 ATS vs. poor teams - outscored by 6+ points per game on the season. 8-2 OVER as a home favorite of 7 points or less. 10-4 OVER after allowing 14 points or less last game.

Cincinnati Bengals:  T. Hendrickson (DL) Injured - Hip. T. Higgins (WR) Injured - Concussion. C. Sample (DL) Injured - Oblique. S. Heyward (LB) Injured - Fibula. C. Brown (RB) Injured - Calf. J. Burton (WR) Injured - Ankle. T. Brooks (RB) Injured - Concussion.

Buffalo Bills:  J. Bosa (DL) Injured - Hamstring. D. Dawkins (OT) Injured - Concussion. R. Ferguson (LS) Injured - Neck. T. Bernard (LB) Injured - Elbow. R. Gilliam (FB) Injured - Knee. J. Palmer (WR) Injured - Knee. D. Kincaid (TE) Injured - Hamstring. S. Brown (OT) Injured - Shoulder. J. Hawes (TE) Injured - Back. T. Sanders (DL) Injured - Wrist.

“It's a lot of fun to watch Joe Burrow play football. Statistically it's not the best game that we've ever had as an offense, but you could feel the rhythm he was in, the confidence he was in.” - Zac Taylor after his team’s win against the Ravens in their last game. 

“Found a way to win, that's all that matters.” - Josh Allen after their win against the Steelers in their last game. 

WR Chase, Ja'Marr

WR Tinsley, Mitch

WR Iosivas, Andrei

TE Gesicki, Mike

QB Burrow, Joe

RB Brown, Chase

WR Davis, Gabe

WR Shavers, Tyrell

WR Shakir, Khalil

TE Knox, Dawson

QB Allen, Josh

RB Cook, James

FB Gilliam, Reggie

Passing: Joe Flacco (1,636)

Rushing: Chase Brown (704)

Receiving: Ja'Marr Chase (971)

Touchdowns: Tee Higgins (7)

Passing: Josh Allen (2,832)

Rushing: James Cook (1,228)

Receiving: Khalil Shakir (569)

Touchdowns: Josh Allen (11)

Coaches:

Cincinnati Bengals: Zac Taylor (7th season)

Buffalo Bills: Sean McDermott (9th season)