Chicago White Sox vs Toronto Blue Jays Prediction, Preview and Odds - 07/17/2026

Game Time: 7:15 pm ET, Friday, July 17, 2026

Venue:  Rogers Centre, Toronto, ON

Where to Watch:  MLB TV, Apple TV

DraftKings:  Moneyline odds:  White Sox +112, Blue Jays -135; Over/Under:  8.5 runs

Bet365:  Moneyline odds:  White Sox +115, Blue Jays -135; Over/Under:  8.5 runs

BetMGM:  Moneyline odds:  White Sox +110, Blue Jays -135; Over/Under:  8.5 runs

Chicago White Sox:  50-45 (1st place, AL Central)

Toronto Blue Jays:  45-51 (5th place, AL East)

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Chicago White Sox:  5-5 last 10

Toronto Blue Jays:  5-5 last 10

The White Sox are entering this series off a win and completed the sweep in their 3-game series against the Athletics 3-0 in their last series. They enter this game with a 50-45 record overall and have a road record of 19-28. This is the series opener of a 3-game series with the Blue Jays on Friday. Their offense ranks 11th in the MLB with a .732 OPS. Rookie pitcher Noah Schultz was their starting pitcher on Sunday while Anthony Kay is making his start in this game on Friday. He is 6-4 with a 4.23 ERA this season. His team lost their last 3 straight games this season with him making an appearance. In his last MLB regular season appearance, he allowed 2 ER, 1 HR, and 2 BB with 4 SO on 4 hits through 5.1 IP against the Boston Red Sox.

The Blue Jays are entering this series off a loss and lost their 3-game series against the San Diego Padres 2-1 in their last series. They enter this game with a 45-51 record overall and have a home record of 24-25. This is the 1st game of a 3-game series with the White Sox on Friday. Their offense ranks 26th in the MLB with a .690 OPS. Kevin Gausman was their starting pitcher on Sunday while rookie pitcher Spencer Miles is making his start in this game on Friday. He is 4-1 with a 2.85 ERA this season. His team won 2 of their last 3 games this season with him making an appearance. In his last MLB regular season start, he allowed 2 earned runs, 0 homers, and 0 walks with 1 strikeout on 7 hits through 4 innings pitched against the San Francisco Giants.

The current betting odds have the Blue Jays listed as a favorite in this game according to Draftkings Sportsbook. The Blue Jays haven't looked good in their games this season with their 45-51 record overall which has them right at the bottom of the AL East. They haven't looked great in their own ballpark either with their 24-25 home record this season. Meanwhile, the White Sox have looked good in their games this season with their 50-45 record overall which has them right at the top of the AL Central. They have been a bad road team though with their 19-28 road record this year. The White Sox have been leading their division with one of the best offenses in MLB, but lately they have been cooling off and they are only 5-5 in their last 10 games now. The Blue Jays are also 5-5 in their last 10 games and haven't looked great, but they were in the Wild Card race for a lot of the season and have slipped down to last in their division now. They will be looking to turn things around coming out of the All-Star break though and they have a good opportunity to start strong with this pitching matchup. The Blue Jays are going with Miles in this one and he has looked good this season. He is 4-1 with a 2.85 ERA and he has been having a great rookie year so far. The team has been having success with him lately, winning 2 of their last 3 games with him starting, and he is coming off a good start in which he only gave up 2 earned runs, something that has been a common theme for him. The White Sox are going with Kay in this one and he hasn't looked great this season. He is 6-4 with a 4.23 ERA and he has been giving up quite a few runs in his starts. He only gave up 2 earned runs in his last start, but that hasn't been a common theme for him this season and the team has also had a lot of trouble with him lately, losing 3 games in a row now with him starting. The break was a good chance for the Blue Jays to reset, so look for them to take advantage of this better pitching matchup and turn things around coming out of the All-Star break. The best way to place a bet here is on the Blue Jays to win this game. 

White Sox Blue Jays Prediction:  Our MLB Pick for Friday, July 17, 2026 (7:15 pm ET start time) is Blue Jays 6 White Sox 4.

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Chicago White Sox: 27-55 (-9.5 units) on the moneyline against AL East opponents. 64-145 (-44.9 units) on the moneyline in road games. 125-250 (-61.2 units) on the moneyline as an underdog of +100 or higher. 28-18 OVER in road games. 27-19 OVER when the total is 8 to 8.5.

Toronto Blue Jays: 55-48 (+6.3 units) on the moneyline against left-handed starters. 62-59 (+10.9 units) on the moneyline vs. good power teams - averaging 1.25 or more HR's/game. 113-114 (+9.4 units) on the moneyline when playing against a team  with a winning record. 16-6 OVER at home when the total is 8 to 8.5. 21-14 OVER as a home favorite of -110 or higher.

Chicago White Sox:  E. Pereira (RF) Seven Day IL - Concussion. T. Gilbert (RP) Fifteen Day IL - Shoulder. A. Hays (LF) Sixty Day IL - Calf. J. Leasure (RP) Sixty Day IL - Flexor. T. Murray (LF) Sixty Day IL - Shoulder. P. Berroa (RP) Sixty Day IL - Elbow. B. Baldwin (LF) Sixty Day IL - Elbow. M. Vasil (RP) Sixty Day IL - Elbow. D. Thorpe (SP) Sixty Day IL - Elbow. K. Bush (SP) Sixty Day IL - Elbow.

Toronto Blue Jays:  J. Sanchez (RF) Ten Day IL - Ankle. M. Scherzer (SP) Fifteen Day IL - Back. J. Mantiply (RP) Sixty Day IL - Knee. L. Sosa (2B) Ten Day IL - Wrist. J. Berrios (SP) Sixty Day IL - Elbow. A. Barger (RF) Ten Day IL - Elbow. C. Ponce (SP) Sixty Day IL - Knee. A. Santander (RF) Sixty Day IL - Shoulder. Y. Garcia (RP) Sixty Day IL - Elbow. B. Francis (SP) Sixty Day IL - Elbow.

“It was a positive way to end things. He’s been working so hard to get into the zone and be in a good spot, and today was a great job of doing that and finishing the first half strong.” - Will Venable on turning to Hicks, Dominguez, and Schweitzer in his team’s win against the A’s in their game on Sunday. 

“This is not where we want to be, obviously. We’ve been trending in the right direction offensively the last two weeks, minus the Seattle series. We definitely have to be better in some areas -- on the mound, at the plate, whatever it is. There are little things we have to be better at and we’re looking for more consistency from regular guys up and down the lineup.” - John Schneider after his team’s loss against the Padres in their game on Sunday.

Sam Antonacci (Z) LF

Munetaka Murakami (Z) 1B

Miguel Vargas (D) 3B

Colson Montgomery (Z) SS

Andrew Benintendi (Z) DH

Kyle Teel (Z) C

Braden Montgomery (A) RF

Tristan Peters (Z) CF

Chase Meidroth (D) 2B

Ernie Clement (D) 2B

Nathan Lukes (Z) RF

Vladimir Guerrero Jr. (D) DH

Kazuma Okamoto (D) 3B

Daulton Varsho (Z) CF

Brandon Valenzuela (A) C

Sean Keys (Z) 1B

Jonatan Clase (A) LF

Andrés Giménez (Z) SS

Batting Average:  Tristan Peters (.301)

Hits:  Chase Meidroth (93)

Home Runs:  Colson Montgomery (23)

RBI:  Miguel Vargas (59)

Stolen Bases:  Luisangel Acuña (15)

Wins:  Davis Martin (9)

Saves:  Seranthony Domínguez (12)

ERA:  Duncan Davitt (0.00)

Batting Average:  Jonatan Clase (.353)

Hits:  Ernie Clement (106)

Home Runs:  Kazuma Okamoto (22)

RBI:  Kazuma Okamoto (62)

Stolen Bases:  Andrés Giménez (10)

Wins:  Dylan Cease (6)

Saves:  Louis Varland (19)

ERA:  Simeon Woods Richardson (0.00)

Managers:

Chicago White Sox: Will Venable (2nd season)

Toronto Blue Jays: John Schneider (5th season)