Chicago White Sox vs New York Yankees Prediction, Preview and Odds - 06/18/2026

Game Time: 7:05 pm ET, Thursday, June 18, 2026

Venue:  Yankee Stadium, Bronx, NY

Where to Watch:  MLB TV

DraftKings:  Moneyline odds:  White Sox +129, Yankees -156; Over/Under:  9.5 runs

Bet365:  Moneyline odds:  White Sox +130, Yankees -155; Over/Under:  9.5 runs

BetMGM:  Moneyline odds:  White Sox +125, Yankees -155; Over/Under:  9.5 runs

Chicago White Sox:  38-33 (1st place, AL Central)

New York Yankees:  44-27 (1st place, AL East)

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Chicago White Sox:  6-4 last 10

New York Yankees:  8-2 last 10

The White Sox are entering this series off a win and won their 3-game series against the Los Angeles Dodgers 2-1 in their last series. They enter this game with a 38-33 record overall and have a road record of 14-21. This is the series finale of a 3-game series with the Yankees on Thursday with the 2nd game still to be played on Wednesday. The White Sox lost the series opener on Tuesday. Their offense ranks 7th in the MLB with a .733 OPS. Anthony Kay is their starting pitcher on Wednesday while Sean Burke is making his start in this game on Thursday. He is 3-4 with a 4.15 ERA this season. His team won 2 of their last 3 games this season with him making an appearance. In his last MLB regular season appearance, he allowed 4 ER, 2 HR, and 5 BB with 6 SO on 6 hits through 4 IP against the Los Angeles Dodgers.

The Yankees are entering this series off a win and won their 3-game series against the Toronto Blue Jays 2-1 in their last series. They enter this game with a 44-27 record overall and have a home record of 20-12. This is the 3rd game of a 3-game series with the White Sox on Thursday with the 2nd game of this series still to be played on Wednesday. The Yankees won the 1st game of this series on Tuesday. Their offense ranks 2nd in the MLB with a .770 OPS. Carlos Rodón is their starting pitcher on Wednesday while Ryan Weathers is making his start in this game on Thursday. He is 2-5 with a 4.36 ERA this season. His team lost their last 3 straight games this season with him making an appearance. In his last MLB regular season start, he allowed 6 earned runs, 2 homers, and 1 walk with 2 strikeouts on 5 hits through 4.1 innings pitched against the Toronto Blue Jays.

The current betting odds have the White Sox listed as an underdog in this game according to Draftkings Sportsbook. The Yankees have looked great in their games this season with their 44-27 record overall which has them right at the top of the AL East with one of the best records in MLB. They have looked great in their own ballpark too with their 20-12 home record this season. Meanwhile, the White Sox have looked good in their games this season with their 38-33 record overall which has them right at the top of the AL Central. They haven't been a good road team though with their 14-21 road record this year. The Yankees have been rolling lately as they are 8-2 in their last 10 games and have one of the best offenses in MLB, but the White Sox also have a really good offense this year and they have been hot themselves, now 6-4 in their last 10 games. The White Sox are going with Burke in this one and he hasn't looked great this season. He is 3-4 with a 4.15 ERA, but lately the team has been having more success with him. They have won 2 of their last 3 games with him starting and even though he gave up 4 earned runs in his last start, he is still the better starter here. The Yankees are going with Weathers in this one and he hasn't looked great this season. He is 2-5 with a 4.36 ERA and he has been giving up quite a few runs this season. He just gave up 6 earned runs in his last start which has been a common theme for him and the team hasn't had much success with him lately either, losing 3 games in a row now with him starting. The White Sox have the offense to go toe-to-toe with the Yankees in this one and they can take advantage of the better pitching matchup to steal a game in this series. The best way to place a bet here is on the White Sox to win this game. 

White Sox Yankees Prediction:  Our MLB Pick for Thursday, June 18, 2026 (7:05 pm ET start time) is White Sox 8 Yankees 4.

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Chicago White Sox: 24-50 (-8.4 units) on the moneyline against AL East opponents. 139-256 (-57.9 units) on the moneyline in all games. 59-138 (-44.2 units) on the moneyline in road games. 22-12 OVER in road games.

New York Yankees: 63-21 (+30.9 units) on the moneyline against AL Central opponents. 58-29 (+9.3 units) on the moneyline as a home favorite of -150 to -200. 175-113 (+6.5 units) on the moneyline vs. an AL team with an on base percentage .330 or worse. 10-4 OVER when the total is 9 to 9.5.

Chicago White Sox:  T. Gilbert (RP) Fifteen Day IL - Shoulder. A. Hays (LF) Sixty Day IL - Calf. M. Murakami (1B) Ten Day IL - Hamstring. J. Leasure (RP) Sixty Day IL - Flexor. N. Schultz (SP) Fifteen Day IL - Knee. J. Hicks (RP) Fifteen Day IL - Lat. K. Teel (C) Sixty Day IL - Hamstring. T. Murray (LF) Sixty Day IL - Shoulder. P. Berroa (RP) Sixty Day IL - Elbow. B. Baldwin (LF) Sixty Day IL - Elbow. M. Vasil (RP) Sixty Day IL - Elbow. D. Thorpe (SP) Sixty Day IL - Elbow. K. Bush (SP) Sixty Day IL - Elbow.

New York Yankees:  J. Dominguez (LF) Day To Day - Tooth. T. Grisham (CF) Ten Day IL - Hamstring. A. Wells (C) Ten Day IL - Cervical Headaches. A. Judge (RF) Ten Day IL - Rib. M. Fried (SP) Fifteen Day IL - Elbow. G. Stanton (DH) Ten Day IL - Leg. C. Schmidt (SP) Sixty Day IL - Elbow.

“Obviously, some things in there we need to clean up.” - Will Venable after his team’s loss against the Yankees in their game on Tuesday. 

“Obviously, that’s a really good pitcher having a great year. Everyone just put together a lot of really good at-bats against him. We did a good job of laying off the pitches he wants you to chase, and we [were] able to slug some too.” - Aaron Boone after his team’s win against the White Sox in their game on Tuesday. 

Sam Antonacci (L) LF

Miguel Vargas (R) 3B

Andrew Benintendi (L) DH

Colson Montgomery (L) SS

Braden Montgomery (S) RF

Chase Meidroth (R) 2B

Jacob Gonzalez (L) 1B

Tristan Peters (L) CF

Drew Romo (S) C

Ben Rice (L) 1B

Cody Bellinger (L) LF

Paul Goldschmidt (R) DH

Jazz Chisholm Jr. (L) 2B

Spencer Jones (L) CF

José Caballero (R) RF

Ryan McMahon (L) 3B

J.C. Escarra (L) C

Anthony Volpe (R) SS

Batting Average:  Randal Grichuk (.310)

Hits:  Chase Meidroth (71)

Home Runs:  Munetaka Murakami (20)

RBI:  Miguel Vargas (44)

Stolen Bases:  Luisangel Acuña (12)

Wins:  Davis Martin (9)

Saves:  Seranthony Domínguez (12)

ERA:  Duncan Davitt (0.00)

Batting Average:  Paul Goldschmidt (.298)

Hits:  Ben Rice (71)

Home Runs:  Ben Rice (20)

RBI:  Ben Rice (49)

Stolen Bases:  Jazz Chisholm (20)

Wins:  Cam Schlittler (7)

Saves:  David Bednar (14)

ERA:  Yovanny Cruz (0.00)

Managers:

Chicago White Sox: Will Venable (2nd season)

New York Yankees: Aaron Boone (9th season)