Chicago White Sox vs Minnesota Twins Prediction, Preview and Odds - 08/28/2026

Game Time: 8:10 pm ET, Friday, August 28, 2026

Venue:  Target Field, Minneapolis, MN

Where to Watch:  MLB TV

DraftKings:  Moneyline odds:  White Sox -106, Twins -114; Over/Under:  9 runs

Bet365:  Moneyline odds:  White Sox -105, Twins -115; Over/Under:  9 runs

BetMGM:  Moneyline odds:  White Sox -105, Twins -115; Over/Under:  9 runs

Chicago White Sox:  70-63 (1st place, AL Central)

Minnesota Twins:  64-70 (3rd place, AL Central)

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Chicago White Sox:  5-5 last 10

Minnesota Twins:  4-6 last 10

The White Sox are entering this series off a win and won their 3-game series against the Texas Rangers 2-1 in their last series. They enter this game with a 70-63 record overall and have a road record of 29-36. This is the series opener of a 3-game series with the Twins on Friday and they have Thursday off as a day of rest. Their offense ranks 7th in the MLB with a .731 OPS. Sean Burke was their starting pitcher on Wednesday while Luis Castillo is making his start in this game on Friday. He is 4-10 with a 5.19 ERA this season. His team lost their last 2 straight games this season with him making an appearance. In his last MLB regular season appearance, he allowed 4 ER, 2 HR, and 1 BB with 3 SO on 8 hits through 2.2 IP against the New York Mets.

The Twins are entering this series off a loss and lost their 3-game series against the Athletics 2-1 in their last series. They enter this game with a 64-70 record overall and have a home record of 35-31. This is the 1st game of a 3-game series with the White Sox on Friday and they have Thursday off as a day of rest. Their offense ranks 13th in the MLB with a .724 OPS. Rookie pitcher Connor Prielipp was their starting pitcher on Wednesday while Dean Kremer is making his start in this game on Friday. He is 2-4 with a 5.22 ERA this season. His team lost their last 2 straight games this season with him making an appearance. In his last MLB regular season start, he allowed 2 earned runs, 1 homer, and 3 walks with 5 strikeouts on 3 hits through 5.1 innings pitched against the San Diego Padres.

The current betting odds have the Twins listed as a slight favorite in this game according to Draftkings Sportsbook. The Twins haven't looked great in their games this season with their 64-70 record overall which has them right in the middle of the AL Central. They have looked a lot better in their own ballpark though with their 35-31 home record this season. Meanwhile, the White Sox have looked good in their games this season with their 70-63 record overall which has them right at the top of the AL Central. They haven't been a great road team though with their 29-36 road record this year. The White Sox just took their last series from the Rangers, but they are only 5-5 in their last 10 games and haven't looked that great lately. The Twins haven't looked great either, now 4-6 in their last 10 games, but they are going to bring their best effort here since this is a big series for them to get back into the division race. The White Sox are going with Castillo in this one and he hasn't looked great this season. He is 4-10 with a 5.19 ERA and he hasn't looked any better since getting traded from the Mariners. He is coming off another bad start giving up 4 earned runs which has been a common theme for him this year and the team has also lost 2 games in a row now with him starting. The Twins are going with Kremer in this one and he hasn't looked great this season either. He is 2-4 with a 5.22 ERA, but he has looked a lot better since getting traded from the Orioles. His team has still lost 2 games in a row now with him starting, but he only gave up 2 earned runs in his last start which is starting to become a common theme for him lately. This is a series that the Twins really need to win and they have looked a lot better at home this year while the White Sox have had a lot more trouble in road games. The best way to place a bet here is on the Twins to win this game. 

White Sox Twins Prediction:  Our MLB Pick for Friday, August 28, 2026 (8:10 pm ET start time) is Twins 5 White Sox 4.

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Chicago White Sox: 70-63 (+17.1 units) on the moneyline in all games. 23-13 (+12.3 units) on the moneyline against division opponents. 50-41 (+17.2 units) on the moneyline against right-handed starters. 33-22 OVER vs. a team with a poor bullpen whose ERA is 4.20 or worse.

Minnesota Twins: 216-242 (-49.1 units) on the moneyline in all games. 116-112 (-23.9 units) on the moneyline in home games. 68-73 (-12.1 units) on the moneyline against division opponents. 7-1 OVER vs. a starting pitcher whose winning percentage is worse than 30%.

Chicago White Sox:  H. Brazoban (RP) Fifteen Day IL - Lat. D. Martin (SP) Fifteen Day IL - Finger. C. Murphy (RP) Fifteen Day IL - Flexor. J. Bart (C) Ten Day IL - Hand. K. Teel (C) Ten Day IL - Ankle. J. Leasure (RP) Sixty Day IL - Flexor. T. Murray (LF) Sixty Day IL - Shoulder. P. Berroa (RP) Sixty Day IL - Elbow. B. Baldwin (LF) Sixty Day IL - Elbow. M. Vasil (RP) Sixty Day IL - Elbow. D. Thorpe (SP) Sixty Day IL - Elbow. K. Bush (SP) Sixty Day IL - Elbow.

Minnesota Twins:  B. Buxton (CF) Day To Day - Back. A. Martin (RF) Ten Day IL - Hamstring. J. Ryan (SP) Fifteen Day IL - Glute. M. Paredes (SP) Sixty Day IL - Oblique. C. Sands (RP) Sixty Day IL - Elbow. A. Banda (RP) Sixty Day IL - Lat. M. Abel (SP) Sixty Day IL - Elbow. D. Festa (SP) Sixty Day IL - Shoulder. P. Lopez (SP) Sixty Day IL - Elbow.

“It's amazing. I don't know what words there are for what he's doing. Really, really special. Really cool to watch. And obviously big for us today, what he did and the rest of the offense.” - Will Venable after his team’s win against the Rangers in their game on Wednesday. 

“We need to continue to add on. It seems like during this road trip, we did not have the ability to add on.” - Derek Shelton after his team’s loss against the A’s in their game on Wednesday.

Miguel Vargas (R) 3B

Munetaka Murakami (L) 1B

Randal Grichuk (R) DH

Chase Meidroth (R) 2B

Braden Montgomery (S) RF

Brenton Doyle (R) CF

Jake Rogers (R) C

Tristan Peters (L) LF

Luisangel Acuña (R) SS

Luke Keaschall (R) CF

Brooks Lee (S) 3B

Josh Bell (S) DH

Ryan Jeffers (R) C

Kody Clemens (L) 2B

Royce Lewis (R) 1B

Trevor Larnach (L) LF

Kaelen Culpepper (R) SS

Alan Roden (L) RF

Batting Average:  Randal Grichuk (.293)

Hits:  Chase Meidroth (130)

Home Runs:  Munetaka Murakami (29)

RBI:  Miguel Vargas (76)

Stolen Bases:  Luisangel Acuña (16)

Wins:  Davis Martin (9)

Saves:  Seranthony Domínguez (12)

ERA:  Hagen Smith (0.93)

Batting Average:  Gabriel Gonzalez (.500)

Hits:  Josh Bell (119)

Home Runs:  Byron Buxton (25)

RBI:  Josh Bell (80)

Stolen Bases:  Luke Keaschall (15)

Wins:  Taj Bradley (9)

Saves:  Yoendrys Gómez (19)

ERA:  Jack Anderson (0.00)

Managers:

Chicago White Sox: Will Venable (2nd season)

Minnesota Twins: Derek Shelton (1st season)