Chicago White Sox vs Houston Astros Prediction, Preview and Odds - 09/02/2026

Game Time: 8:10 pm ET, Wednesday, September 2, 2026

Venue:  Daikin Park, Houston, TX

Where to Watch:  MLB TV

DraftKings:  Moneyline odds:  White Sox +109, Astros -131; Over/Under:  8.5 runs

Bet365:  Moneyline odds:  White Sox +110, Astros -130; Over/Under:  8.5 runs

BetMGM:  Moneyline odds:  White Sox +105, Astros -130; Over/Under:  8.5 runs

Chicago White Sox:  72-65 (1st place, AL Central)

Houston Astros:  70-68 (1st place, AL West)

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Chicago White Sox:  6-4 last 10

Houston Astros:  6-4 last 10

The White Sox are entering this series off a loss and won their 3-game series against the Minnesota Twins 2-1 in their last series. They enter this game with a 72-65 record overall and have a road record of 31-38. This is the 3rd game of a 4-game series with the Astros on Wednesday with the 2nd game still to be played on Tuesday. The White Sox lost the series opener on Monday. Their offense ranks 9th in the MLB with a .727 OPS. Sean Burke is their starting pitcher on Tuesday while Davis Martin is making his start in this game on Wednesday. He is 9-6 with a 4.32 ERA this season. His team lost 2 of their last 3 games this season with him making an appearance. In his last MLB regular season appearance, he allowed 3 ER, 2 HR, and 1 BB with 3 SO on 2 hits through 2 IP against the Cincinnati Reds.

The Astros are entering this series off a win and won their 3-game series against the New York Mets 2-1 in their last series. They enter this game with a 70-68 record overall and have a home record of 34-35. This is the 3rd game of a 4-game series with the White Sox on Wednesday with the 2nd game of this series still to be played on Tuesday. The Astros won the 1st game of this series on Monday. Their offense ranks 11th in the MLB with a .726 OPS. Ronel Blanco is their starting pitcher on Tuesday while Hayden Wesneski is making his start in this game on Wednesday. He is 4-1 with a 3.86 ERA this season. His team won their last 2 straight games this season with him making an appearance. In his last MLB regular season start, he allowed 1 earned run, 0 homers, and 2 walks with 6 strikeouts on 3 hits through 5 innings pitched against the New York Yankees.

The current betting odds have the Astros listed as a favorite in this game according to Draftkings Sportsbook. The Astros have looked good in their games this season with their 70-68 record overall which has them right at the top of the AL West. They haven't looked great in their own ballpark though with their 34-35 home record this season. Meanwhile, the White Sox have looked good in their games this season with their 72-65 record overall which has them right at the top of the AL Central. They haven't been a good road team though with their 31-38 road record this year. The White Sox are 6-4 in their last 10 games and they have looked good lately, but they did lose the 1st game of this series and they have some pitching troubles. The Astros are also 6-4 in their last 10 games, getting hot lately as they look to keep their division lead, and their pitching staff has been great over the last month which could give them the edge here. Martin could be returning for the White Sox in this game, but he looked terrible right before getting injured, so the White Sox aren't going to have their best on the mound in this one. The Astros are going with Wesneski and he hasn't looked bad this season. He is 4-1 with a 3.86 ERA and he hasn't made many starts this year, but the team has been having a ton of success in those few starts. They have won 2 games in a row now with him starting and he is also coming off a great start in which he gave up 1 earned run. The Astros are going to have the edge in this one with the more reliable starter and they also have the stronger bullpen to lean on late. The best way to place a bet here is on the Astros to win this game. 

White Sox Astros Prediction:  Our MLB Pick for Wednesday, September 2, 2026 (8:10 pm ET start time) is Astros 5 White Sox 3.

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Chicago White Sox: 173-288 (-53.8 units) on the moneyline in all games. 76-155 (-40.5 units) on the moneyline in road games. 127-213 (-38.4 units) on the moneyline against right-handed starters. 17-10 OVER against AL West opponents.

Houston Astros: 138-108 (+6.6 units) on the moneyline vs. an AL team with a slugging percentage .410 or worse on the season. 112-101 (+10.4 units) on the moneyline when playing against a team with a winning record. 162-138 (+15.2 units) on the moneyline vs. a team with a good bullpen whose WHIP is 1.350 or better. 32-17 OVER when playing against a team with a winning record.

Chicago White Sox:  H. Brazoban (RP) Fifteen Day IL - Lat. D. Martin (SP) Fifteen Day IL - Finger. C. Murphy (RP) Fifteen Day IL - Flexor. J. Bart (C) Ten Day IL - Hand. K. Teel (C) Ten Day IL - Ankle. J. Leasure (RP) Sixty Day IL - Flexor. T. Murray (LF) Sixty Day IL - Shoulder. P. Berroa (RP) Sixty Day IL - Elbow. B. Baldwin (LF) Sixty Day IL - Elbow. M. Vasil (RP) Sixty Day IL - Elbow. D. Thorpe (SP) Sixty Day IL - Elbow. K. Bush (SP) Sixty Day IL - Elbow.

Houston Astros:  B. Matthews (CF) Sixty Day IL - Knee. M. Burrows (SP) Fifteen Day IL - Elbow. C. Correa (SS) Sixty Day IL - Ankle. B. Walter (RP) Sixty Day IL - Elbow.

“Yeah, great day by Colson. Really nice to see and Mune too, just making good swing decisions. You look back at the last little stretch here, those two, Vargy [Miguel Vargas] included, where they are taking walks. They are making good swing decisions. We just aren’t getting that big hit. Really nice to see from Colson since he’s gone in and out of feeling really good, that was a really good day for him.” - Will Venable after his team’s loss against the Astros in their game on Monday.

“Big swing by Velázquez, Cam Smith drove the ball and had some hard contact. We had some really good at-bats against [White Sox starter Anthony] Kay. I thought our righties in the bottom of the lineup did a nice job.” - Joe Espada after his team’s win against the White Sox in their game on Monday. 

Sam Antonacci (L) LF

Munetaka Murakami (L) 1B

Miguel Vargas (R) 3B

Andrew Benintendi (L) DH

Braden Montgomery (S) RF

Colson Montgomery (L) SS

Chase Meidroth (R) 2B

Tristan Peters (L) CF

Jake Rogers (R) C

Jeremy Peña (R) SS

Yordan Alvarez (L) DH

Isaac Paredes (R) 3B

Christian Walker (R) 1B

Daulton Varsho (L) CF

Cam Smith (R) RF

Nelson Velázquez (R) LF

Nick Allen (R) 2B

Christian Vázquez (R) C

Batting Average:  Randal Grichuk (.287)

Hits:  Chase Meidroth (132)

Home Runs:  Munetaka Murakami (29)

RBI:  Colson Montgomery (77)

Stolen Bases:  Sam Antonacci (17)

Wins:  Davis Martin (9)

Saves:  Seranthony Domínguez (12)

ERA:  Hagen Smith (0.82)

Batting Average:  Yordan Alvarez (.317)

Hits:  Yordan Alvarez (155)

Home Runs:  Yordan Alvarez (37)

RBI:  Yordan Alvarez (94)

Stolen Bases:  Cam Smith (10)

Wins:  Peter Lambert (8)

Saves:  Josh Hader (21)

ERA:  Josh Hader (0.74)

Managers:

Chicago White Sox: Will Venable (2nd season)

Houston Astros: Joe Espada (3rd season)