Chicago White Sox vs Boston Red Sox Prediction, Preview and Odds - 08/04/2026

Game Time: 7:10 pm ET, Tuesday, August 4, 2026

Venue:  Fenway Park, Boston, MA

Where to Watch:  MLB TV

DraftKings:  Moneyline odds:  White Sox +102, Red Sox -122; Over/Under:  9 runs

Bet365:  Moneyline odds:  White Sox +100, Red Sox -120; Over/Under:  9 runs

BetMGM:  Moneyline odds:  White Sox +100, Red Sox -120; Over/Under:  9 runs

Chicago White Sox:  59-52 (1st place, AL Central)

Boston Red Sox:  60-51 (3rd place, AL East)

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Chicago White Sox:  5-5 last 10

Boston Red Sox:  8-2 last 10

The White Sox are entering this series off a win and won their 3-game series against the Tampa Bay Rays 2-1 in their last series. They enter this game with a 59-52 record overall and have a road record of 25-31. This is the series opener of a 3-game series with the Red Sox on Tuesday and they have Monday off as a day of rest. Their offense ranks 14th in the MLB with a .724 OPS. Anthony Kay was their starting pitcher on Sunday while Davis Martin is making his start in this game on Tuesday. He is 9-5 with a 3.62 ERA this season. His team lost 4 of their last 5 games this season with him making an appearance. In his last MLB regular season appearance, he allowed 4 ER, 1 HR, and 2 BB with 6 SO on 5 hits through 6 IP against the New York Yankees.

The Red Sox are entering this series off a win and completed the sweep in their 3-game series against the Los Angeles Dodgers 3-0 in their last series. They enter this game with a 60-51 record overall and have a home record of 25-29. This is the 1st game of a 3-game series with the White Sox on Tuesday and they have Monday off as a day of rest. Their offense ranks 18th in the MLB with a .712 OPS. Jake Bennett was their starting pitcher on Sunday while Patrick Sandoval is making his start in this game on Tuesday. He is 0-0 with a 3.32 ERA this season. His team won their last 4 straight games this season with him making an appearance. In his last MLB regular season start, he allowed 2 earned runs, 2 homers, and 2 walks with 7 strikeouts on 5 hits through 5 innings pitched against the Athletics.

The current betting odds have the Red Sox listed as a slight favorite in this game according to Draftkings Sportsbook. The Red Sox have looked good in their games this season with their 60-51 record overall which has them right in the middle of the AL East. They haven't looked good in their own ballpark though with their 25-29 home record this season. Meanwhile, the White Sox have looked good in their games this season with their 59-52 record overall which has them right at the top of the AL Central. They haven't been a good road team though with their 25-31 road record this year. The White Sox have been a big surprise this season with one of the best offenses in MLB too, but they are 5-5 in their last 10 games and haven't looked great lately. The Red Sox had a terrible start to the season and were well out of the playoff race, but they have been the hottest team in the league over the last month and have been rolling lately, now 8-2 in their last 10 games. The White Sox are going with Martin in this one and he has looked good this season. He is 9-5 with a 3.62 ERA, but lately he hasn't looked good. He gave up 4 earned runs in his last start which is starting to become a common theme for him as of late and the team has had a lot of trouble now too, losing 4 of their last 5 games with him starting. The Red Sox are going with Sandoval in this one and he has looked good this season. He is 0-0 with a 3.32 ERA and he hasn't been giving up many runs. He only gave up 2 earned runs in his last start which has been a common theme for him and the team has been having a lot of success with him too, winning 4 games in a row now with him starting. The Red Sox have had great pitching all season too and now their offense is starting to follow suit, so look for them to take advantage of this pitching matchup with Martin starting to look shaky as of late. The best way to place a bet here is on the Red Sox to win this game. 

White Sox Red Sox Prediction:  Our MLB Pick for Tuesday, August 4, 2026 (7:10 pm ET start time) is Red Sox 5 White Sox 2.

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Chicago White Sox: 33-59 (-6.5 units) on the moneyline against AL East opponents. 160-275 (-54 units) on the moneyline in all games. 70-148 (-40.6 units) on the moneyline in road games. 13-7 UNDER revenging a same season 3 game sweep at home against an opponent.

Boston Red Sox: 172-148 (+6.7 units) on the moneyline against right-handed starters. 153-125 (+12.1 units) on the moneyline vs. an AL team with an on base percentage .330 or worse. 122-108 (+16.4 units) on the moneyline when playing against a team with a winning record. 16-7 UNDER vs. a starting pitcher who gives up 0.5 or less HR's/start.

Chicago White Sox:  B. Montgomery (RF) Day To Day - Ankle. K. Teel (C) Ten Day IL - Ankle. T. Gilbert (RP) Fifteen Day IL - Shoulder. A. Hays (LF) Sixty Day IL - Calf. J. Leasure (RP) Sixty Day IL - Flexor. T. Murray (LF) Sixty Day IL - Shoulder. P. Berroa (RP) Sixty Day IL - Elbow. B. Baldwin (LF) Sixty Day IL - Elbow. M. Vasil (RP) Sixty Day IL - Elbow. D. Thorpe (SP) Sixty Day IL - Elbow. K. Bush (SP) Sixty Day IL - Elbow.

Boston Red Sox:  C. Mead (3B) Ten Day IL - Hand. Z. Kelly (RP) Sixty Day IL - Elbow. R. Anthony (LF) Sixty Day IL - Wrist. M. Mayer (2B) Ten Day IL - Forearm. I. Kiner-Falefa (2B) Ten Day IL - Forearm. G. Crochet (SP) Sixty Day IL - Shoulder. T. Story (SS) Sixty Day IL - Abdomen. K. Crawford (SP) Sixty Day IL - Wrist. T. Casas (1B) Sixty Day IL - Knee. J. Oviedo (SP) Sixty Day IL - Elbow. T. Houck (SP) Sixty Day IL - Elbow.

“Yeah, it was huge. To get two runs early is, obviously, a nice way to start the game. And really, because of those two errors, Obviously, they're such a good defensive team that they usually make those. But a good job by our guys to take advantage. We're just a really competitive group. When you compete, take advantage of those opportunities, that's a path to winning. We talk about continuing to battle and grind every at-bat and these guys do a great job.” - Will Venable after his team’s win against the Rays in their game on Sunday. 

"They grab a lead, but you find a way to get out of the inning in a one-run ballgame and then respond immediately. They've been doing that for a month. Felt like the game swung in our favor and then we held on from there." - Chad Tracy after his team’s win against the LA Dodgers in their game on Sunday. 

Sam Antonacci (L) LF

Munetaka Murakami (L) 1B

Miguel Vargas (R) 3B

Colson Montgomery (L) SS

Andrew Benintendi (L) DH

Tristan Peters (L) CF

Chase Meidroth (R) 2B

Everson Pereira (R) RF

Drew Romo (S) C

Nick Sogard (S) 2B

Ceddanne Rafaela (R) CF

Wilyer Abreu (L) RF

Willson Contreras (R) 1B

Masataka Yoshida (L) DH

Caleb Durbin (R) 3B

Andruw Monasterio (R) SS

Jarren Duran (L) LF

Carlos Narváez (R) C

Batting Average:  Randal Grichuk (.276)

Hits:  Chase Meidroth (108)

Home Runs:  Colson Montgomery (25)

RBI:  Miguel Vargas (66)

Stolen Bases:  Luisangel Acuña (15)

Wins:  Davis Martin (9)

Saves:  Seranthony Domínguez (12)

ERA:  Grant Taylor (2.40)

Batting Average:  Jahmai Jones (.385)

Hits:  Ceddanne Rafaela (120)

Home Runs:  Willson Contreras (23)

RBI:  Willson Contreras (67)

Stolen Bases:  Jarren Duran (15)

Wins:  Sonny Gray (13)

Saves:  Aroldis Chapman (27)

ERA:  Aroldis Chapman (1.67)

Managers:

Chicago White Sox: Will Venable (2nd season)

Boston Red Sox: Chad Tracy (Interim)