by Rod Pearson
Tuesday, Jun 03, 2025
Game Time: 6:45 pm ET, Wednesday, June 4, 2025
Venue: Nationals Park, Washington, DC
Where to Watch: MASN
Opening Odds at USA Sportsbooks
DraftKings: Moneyline odds: Cubs -135, Nationals +114; Over/Under: 8.5 runs
Bet365: Moneyline odds: Cubs -135, Nationals +115; Over/Under: 8.5 runs
BetMGM: Moneyline odds: Cubs -135, Nationals +115; Over/Under: 8.5 runs
Season Record
Chicago Cubs: 37-22 (1st place, NL Central)
Washington Nationals: 28-31 (3rd place, NL East)
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Recent Form
Chicago Cubs: 8-2 last 10
Washington Nationals: 6-4 last 10
Chicago Cubs vs Washington Nationals Preview and Analysis
The Cubs are entering this series off a win and won their 3-game series against the Cincinnati Reds 2-1 in their last series. They enter this game with a 37-22 record overall and have a road record of 17-11. This is the 2nd game of a 3-game series with the Nationals on Wednesday with the series opener still to be played on Tuesday. Their offense ranks 3rd in the MLB with a .783 OPS. Rookie pitcher Cade Horton is their starting pitcher on Tuesday while Matthew Boyd is making his start in this game on Wednesday. He is 5-2 with a 3.08 ERA this season. His team won their last 3 straight games this season with him making an appearance. In his last MLB regular season start, he allowed 0 ER, 0 HR, and 0 BB with 8 Ks on 4 hits through 6 IP against the Colorado Rockies.
The Nationals are entering this series off a loss and won their 3-game series against the Arizona Diamondbacks 2-1 in their last series. They enter this game with a 28-31 record overall and have a home record of 13-14. This is the 2nd game of a 3-game series with the Cubs on Wednesday with the 1st game of this series still to be played on Tuesday. Their offense ranks 15th in the MLB with a .709 OPS. Trevor Williams is their starting pitcher on Tuesday while MacKenzie Gore is making his start in this game on Wednesday. He is 2-5 with a 3.16 ERA this season. His team won 2 of their last 3 games this season with him making an appearance. In his last MLB regular season start, he allowed 0 earned runs, 0 homers, and 0 BB with 8 strikeouts on 4 hits through 6 innings played against the Seattle Mariners.
Cubs vs Nationals Prediction
The current betting odds have the Cubs listed as a favorite in this game according to Draftkings Sportsbook. The Cubs have looked really good in their games this season with their 37-22 record overall which has them right at the top of the NL Central with one of the best records in the entire MLB. They have also been a good road team this year with their 17-11 road record. Meanwhile, the Nationals haven't looked great in their games this season with their 28-31 record overall which has them right in the middle of the NL East. They haven't looked great in their own ballpark either with their 13-14 home record this season. The Nationals have looked a lot better lately too as they are starting to get hot, going 6-4 in their last 10 games, but the Cubs have still been the hotter team lately as they are 8-2 in their last 10 games. Boyd is on the mound for the Cubs in this one and he has been one of their better starters this season. He is 5-2 with a 3.08 ERA and he is coming off a great start in which he gave up no runs. The team has also had a lot of success with him on the mound, winning their last 3 games in a row now with him starting. Gore is on the mound for the Nationals in this one and he hasn't looked bad this season, but he has also been really up and down in his starts. He is coming off a great start in which he gave up no runs, but he is still 2-5 with a 3.16 ERA this year. The team has won 2 of their last 3 games with him starting now, but the Cubs also have one of the best offenses in the MLB so he is not going to replicate that last start he had against this lineup. The best way to place a bet here is on the Cubs to win this game.
Cubs Nationals Prediction: Our MLB Pick for Wednesday, June 4, 2025 (6:45 pm ET start time) is Cubs 6 Nationals 4.
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MLB Betting Trends
Chicago Cubs: 34-42 (-13 units) on the moneyline against NL East opponents. 87-109 (-25.9 units) on the moneyline when the money line is +125 to -125. 73-73 (-16.1 units) on the moneyline vs. NL teams allowing 4.5 or more runs/game on the season. 4-1 OVER on the road vs. a team with a poor bullpen whose WHIP is 1.550 or worse.
Washington Nationals: 169-213 (+30.4 units) on the moneyline in all games. 140-186 (+34.6 units) on the moneyline as an underdog of +100 or higher. 84-126 (+12.9 units) on the moneyline when playing against a team with a winning record. 15-6 OVER at home when playing against a top-level team (Win Pct. > 62%).
Key Injuries
Chicago Cubs: K. Tucker (RF) Day To Day - Finger. M. Amaya (C) Ten Day IL - Oblique. P. Hodge (RP) Fifteen Day IL - Oblique. T. Miller (RP) Sixty Day IL - Hip. E. Morgan (RP) Sixty Day IL - Elbow. S. Imanaga (SP) Fifteen Day IL - Leg. J. Assad (RP) Sixty Day IL - Oblique. J. Steele (SP) Sixty Day IL - Elbow.
Washington Nationals: J. Young (CF) Ten Day IL - Shoulder. D. Crews (RF) Ten Day IL - Back. P. DeJong (3B) Ten Day IL - Face. O. Ribalta (RP) Fifteen Day IL - Bicep. D. Law (RP) Fifteen Day IL - Forearm. D. Herz (SP) Sixty Day IL - Elbow. M. Thompson (RP) Sixty Day IL - Elbow. J. Gray (SP) Sixty Day IL - Elbow.
Notable Quotes
“Just a bunch of different guys. Different guys every day. That’s how you’re consistent offensively.” - Craig Counsell after his team’s win against the Reds in their game on Sunday.
“Our young guys are doing a lot better. I want to give them the opportunity to go out there and, like I said, let's see what we have here, let’s see what we have in the future. We're trying to build something special.” - Dave Martinez after his team’s win against the Diamondbacks in their game on Sunday.
Starting Lineups
Chicago Cubs
Ian Happ (S) LF
Kyle Tucker (L) RF
Seiya Suzuki (R) DH
Pete Crow-Armstrong (L) CF
Dansby Swanson (R) SS
Michael Busch (L) 1B
Nico Hoerner (R) 2B
Matt Shaw (R) 3B
Reese McGuire (L) C
Washington Nationals
CJ Abrams (L) SS
James Wood (L) LF
Nathaniel Lowe (L) 1B
Luis García Jr. (L) 2B
Josh Bell (S) DH
Robert Hassell III (L) CF
Keibert Ruiz (S) C
José Tena (L) 3B
Daylen Lile (L) RF
Statistical Leaders
Chicago Cubs
Batting Average: Nico Hoerner (.301)
Hits: Pete Crow-Armstrong (65)
Home Runs: Pete Crow-Armstrong (15)
RBI: Seiya Suzuki (52)
Stolen Bases: Pete Crow-Armstrong (19)
Wins: Matthew Boyd (5)
Saves: Daniel Palencia (5)
ERA: Drew Pomeranz (0.00)
Washington Nationals
Batting Average: Trey Lipscomb (.500)
Hits: James Wood (64)
Home Runs: James Wood (16)
RBI: James Wood (44)
Stolen Bases: Dylan Crews (11)
Wins: Jorge López (6)
Saves: Kyle Finnegan (16)
ERA: Andrew Chafin (2.00)
Managers:
Chicago Cubs: Craig Counsell (2nd season)
Washington Nationals: Dave Martinez (8th season)
Rod Pearson
About the Author:
Rod Pearson has been a rabid sports fan his entire life. He grew up in Ontario, and was skilled in both hockey and baseball, and pitched in an elite baseball league for many years. In 2022, Rod decided to hang up his glove, so that he could write about the sports he loves -- but from a gambling perspective. Join Rod every day as he breaks down the games to find the best betting value.
