Chicago Cubs vs Seattle Mariners Prediction, Preview and Odds - 08/22/2026

Game Time: 7:15 pm ET, Saturday, August 22, 2026

Venue:  T-Mobile Park, Seattle, WA

Where to Watch:  MLB TV, FOX

DraftKings:  Moneyline odds:  Cubs -102, Mariners -118; Over/Under:  7.5 runs

Bet365:  Moneyline odds:  Cubs +100, Mariners -120; Over/Under:  7.5 runs

BetMGM:  Moneyline odds:  Cubs +100, Mariners -120; Over/Under:  7.5 runs

Chicago Cubs:  74-54 (2nd place, NL Central)

Seattle Mariners:  60-68 (3rd place, AL West)

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Chicago Cubs:  6-4 last 10

Seattle Mariners:  4-6 last 10

The Cubs are entering this series off a loss and won their 3-game series against the Chicago White Sox 2-1 in their last series. They enter this game with a 74-54 record overall and have a road record of 36-27. This is the 2nd game of a 3-game series with the Mariners on Saturday with the series opener still to be played on Friday. Their offense ranks 3rd in the MLB with a .755 OPS. Matthew Boyd is their starting pitcher on Friday while David Peterson is making his start in this game on Saturday. He is 7-7 with a 5.29 ERA this season. His team won their last 6 straight games this season with him making an appearance. In his last MLB regular season appearance, he allowed 0 ER, 0 HR, and 1 BB with 1 SO on 0 hits through 1.1 IP against the Chicago White Sox.

The Mariners are entering this series off a loss and lost their 3-game series against the Milwaukee Brewers 2-1 in their last series. They enter this game with a 60-68 record overall and have a home record of 33-29. This is the 2nd game of a 3-game series with the Cubs on Saturday with the 1st game of this series still to be played on Friday. Their offense ranks 28th in the MLB with a .685 OPS. Emerson Hancock is their starting pitcher on Friday while rookie pitcher Kade Anderson is making his start in this game on Saturday. He is 0-0 with a 0.00 ERA this season. He has been called for his MLB debut on Saturday.

The current betting odds have the Cubs listed as a slight underdog in this game according to Draftkings Sportsbook. The Cubs have looked really good in their games this season with their 74-54 record overall which has them right near the top of the NL Central. They have been a good road team too with their 36-27 road record this year. Meanwhile, the Mariners haven't looked good in their games this season with their 60-68 record overall which has them right in the middle of the AL West. They have looked a lot better in their own ballpark though with their 33-29 home record this season. The Mariners have been in a big slump lately and they haven't been getting any better. They are 4-6 in their last 10 games now and coming off another series loss against the Brewers. The Cubs are 6-4 in their last 10 games and they do have some momentum on their side after another series win against the White Sox. The Cubs are going with Peterson in this one and he hasn't looked good this season. He is 7-7 with a 5.29 ERA, but he has looked a lot better since getting traded to the Cubs. He is coming off another good appearance giving up no runs which has been becoming a common theme for him lately and his team has been having lots of success with him too, winning 6 games in a row now with him pitching in the game. The Mariners are going with Anderson in this one and he will be making his MLB debut in this game. He has looked great in the minors, but this is a big step for him to take so late in the season when his team desperately needs some wins. The Mariners just aren't in a good situation right now as a team, so backing this rookie in his 1st ever start is tough since the Mariners also have one of the worst offenses in MLB. The best way to place a bet here is on the Cubs to win this game. 

Cubs Mariners Prediction:  Our MLB Pick for Saturday, August 22, 2026 (7:15 pm ET start time) is Cubs 9 Mariners 5.

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Chicago Cubs: 254-206 (+20.1 units) on the moneyline in all games. 117-111 (+8 units) on the moneyline in road games. 78-59 (+10.1 units) on the moneyline in an inter-league game. 24-13 OVER against left-handed starters.

Seattle Mariners: 241-224 (-22.8 units) on the moneyline in all games. 129-124 (-25.6 units) on the moneyline when the money line is -100 to -150. 68-65 (-6.7 units) on the moneyline in an inter-league game. 37-24 OVER when the total is 7 to 7.5.

Chicago Cubs:  K. Gausman (SP) Day To Day - Hand. P. Maton (RP) Sixty Day IL - Knee. E. Cabrera (SP) Fifteen Day IL - Blister. D. Swanson (SS) Ten Day IL - Side. D. Palencia (RP) Sixty Day IL - Elbow. B. Brown (RP) Sixty Day IL - Neck. G. Hollowell (RP) Fifteen Day IL - Shoulder. M. Shaw (RF) Ten Day IL - Hand. H. Milner (RP) Fifteen Day IL - Appendicitis. R. Martin (RP) Sixty Day IL - Elbow. P. Hodge (RP) Sixty Day IL - Elbow. C. Horton (SP) Sixty Day IL - Forearm. H. Harvey (RP) Sixty Day IL - Tricep. J. Steele (SP) Sixty Day IL - Elbow. T. Austin (1B) Sixty Day IL - Knee. S. Miller (RP) Sixty Day IL - Elbow.

Seattle Mariners:  C. Emerson (SS) Ten Day IL - Wrist. C. Sulser (RP) Fifteen Day IL - Oblique. L. Raley (RF) Sixty Day IL - Elbow. J. Crawford (SS) Ten Day IL - Wrist. W. Wilson (3B) Sixty Day IL - Thumb. M. Brash (RP) Fifteen Day IL - Lat. C. Criswell (RP) Sixty Day IL - Shoulder. C. Vargas (RP) Sixty Day IL - Lat. L. Evans (SP) Sixty Day IL - Arm.

“I thought he was really good. Breggy had a great game at third base, I thought, on defense. But, the ball was on the ground. I thought he pitched very, very well.” - Craig Counsell after his team’s loss against the White Sox in their game on Wednesday. 

“He has been, since he’s been back, the on-base machine that we thought. Getting base hits, again, not trying to do too much. Getting the ball up the middle, working his walks here and there, fighting off pitches, long at-bats.” - Dan Wilson on Brendan Donovan after his team’s loss against the Brewers in their game on Thursday.

Pete Crow-Armstrong (L) DH

Seiya Suzuki (R) RF

Alex Bregman (R) 3B

Michael Busch (L) 1B

Nico Hoerner (R) SS

Pedro Ramírez (S) 2B

Carson Kelly (R) C

Ian Happ (S) LF

Tyrone Taylor (R) CF

Brendan Donovan (L) 3B

Randy Arozarena (R) LF

Dominic Canzone (L) RF

Julio Rodríguez (R) CF

Josh Naylor (L) 1B

Taylor Ward (R) DH

Cole Young (L) 2B

Jhonny Pereda (R) C

Brock Rodden (S) SS

Batting Average:  Justin Dean (.375)

Hits:  Pete Crow-Armstrong (136)

Home Runs:  Pete Crow-Armstrong (31)

RBI:  Pete Crow-Armstrong (79)

Stolen Bases:  Pete Crow-Armstrong (31)

Wins:  Colin Rea (8)

Saves:  Jacob Webb (9)

ERA:  Ty Blach (0.00)

Batting Average:  Brock Rodden (.300)

Hits:  Josh Naylor (124)

Home Runs:  Dominic Canzone (19)

RBI:  Cole Young (56)

Stolen Bases:  Josh Naylor (25)

Wins:  Logan Gilbert (10)

Saves:  Andrés Muñoz (23)

ERA:  Matt Brash (0.54)

Managers:

Chicago Cubs: Craig Counsell (3rd season)

Seattle Mariners: Dan Wilson (3rd season)