Chicago Cubs vs San Diego Padres Prediction, Preview and Odds - 04/15/2025

Game Time: 9:40 pm ET, Tuesday, April 15, 2025

Venue:  Petco Park, San Diego, CA

Where to Watch:  PADRES.tv

DraftKings:  Moneyline odds:  Cubs -125, Padres +105; Over/Under:  7.5 runs

Bet365:  Moneyline odds:  Cubs -125, Padres +105; Over/Under:  7.5 runs

BetMGM:  Moneyline odds:  Cubs -125, Padres +105; Over/Under:  7.5 runs

Chicago Cubs:  11-7 (1st place, NL Central)

San Diego Padres:  13-3 (1st place, NL West)

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Chicago Cubs:  7-3 last 10

San Diego Padres:  7-3 last 10

The Cubs are entering this series off a win and won their 3-game series against the Los Angeles Dodgers 2-1 in their last series. They enter this game with an 11-7 record overall and have a road record of 7-3. This is the 2nd game of a 3-game series with the Padres on Tuesday with the series opener still to be played on Monday. Their offense ranks 2nd in the MLB with a .787 OPS. Jameson Taillon is their starting pitcher on Monday while Shota Imanaga is making his start in this game on Tuesday. He is 2-1 with a 2.70 ERA this season. His team won 2 of their last 3 games this season with him making an appearance. In his last MLB regular season start, he allowed 5 ER, 2 HR, and 1 BB with 4 Ks on 7 hits through 5 IP against the Texas Rangers.

The Padres are entering this series off a win and completed the sweep in their 3-game series against the Colorado Rockies 3-0 in their last series. They enter this game with a 13-3 record overall and have a home record of 10-0. This is the 2nd game of a 3-game series with the Cubs on Tuesday with the 1st game still to be played on Monday. Their offense ranks 5th in the MLB with a .771 OPS. Dylan Cease is their starting pitcher on Monday while Randy Vásquez is making his start in this game on Tuesday. He is 1-1 with a 1.72 ERA this season. His team won 2 of their last 3 games this season with him making an appearance. In his last MLB regular season start, he allowed 1 earned run, 0 homers, and 3 BB with 1 strikeout on 1 hit through 5 innings played against the Athletics.

The current betting odds have the Padres listed as a slight underdog in this game according to Draftkings Sportsbook. The Padres have looked great in their games this season with their 13-3 record overall which has them right at the top of their division with one of the best records in the entire MLB. They have also looked great in their own ballpark with their 10-0 home record this season. Meanwhile, the Cubs have looked really good in their games this season with their 11-7 record overall which has them right at the top of their division with a good start to the season. They have also been a really good road team this year with their 7-3 road record so far. The Cubs have been hitting well this season and they are coming off a series win over the Dodgers in their last one, but as good as the Cubs have been this season, the Padres have been even better. The Padres also have a really good offense that has been one of the best in the MLB to start the season, but their pitching has been a lot better than the Cubs. They also have the better pitching matchup here with Vasquez on the mound. Vasquez has been great all season and is coming off another good start in his last one. The Cubs also have a solid starter with Imanaga on the mound, but he is coming off a bad start which he gave up 5 earned runs in and he is going to get himself into trouble here with the way the Padres have been playing. The best way to place a bet here is on the Padres to win this game. 

Cubs Padres Prediction:  Our MLB Pick for Tuesday, April 15, 2025 (9:40 pm ET start time) is Padres 6 Cubs 1.

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Chicago Cubs: 177-164 (+6.7 units) on the moneyline in all games. 132-121 (+9.6 units) on the moneyline against right-handed starters. 22-15 (+11 units) on the moneyline when playing against a top-level team (Win Pct. > 62%). 7-2 OVER vs. an NL team with a team batting average of .275 or better.

San Diego Padres: 34-33 (-10.3 units) on the moneyline against NL Central opponents. 65-72 (-10.6 units) on the moneyline when the money line is +125 to -125. 73-66 (-16.9 units) on the moneyline vs. a team with a poor bullpen whose ERA is 4.20 or worse. 30-24 OVER at home when the money line is +125 to -125.

Chicago Cubs:  J. Steele (SP) Fifteen Day IL - Elbow. R. Brasier (RP) Fifteen Day IL - Hip. V. Brujan (SS) Ten Day IL - Elbow. T. Miller (RP) Fifteen Day IL - Hip. J. Assad (RP) Fifteen Day IL - Oblique.

San Diego Padres:  J. Cronenworth (1B) Ten Day IL - Rib. M. Waldron (SP) Sixty Day IL - Oblique. J. Merrill (CF) Ten Day IL - Hamstring. J. Brito (RP) Sixty Day IL - Forearm. B. Hoeing (RP) Fifteen Day IL - Shoulder. S. Reynolds (RP) Fifteen Day IL - Foot. Y. Darvish (SP) Fifteen Day IL - Elbow. J. Musgrove (SP) Sixty Day IL - Elbow.

“It’s kind of the life of a Major League pitcher. I talked to him this morning again, and he’s got a great attitude about it, as he always does, and knows that it’s kind of part of the career that he’s chosen. He’ll take it a step at a time and do the best he can to come back even better.” - Craig Counsell on the injury to Justin Steele.

“It’s a fun place to play; we feel like we’re playing with our fans. And conversely, it’s a really challenging place [for opponents] to play. It’s a playoff-like atmosphere almost every game.” - Mike Shildt after his team’s win against the Rockies in their game on Sunday.

Ian Happ (S) LF

Kyle Tucker (L) RF

Justin Turner (R) DH

Michael Busch (L) 1B

Dansby Swanson (R) SS

Nico Hoerner (R) 2B

Pete Crow-Armstrong (L) CF

Carson Kelly (R) C

Matt Shaw (R) 3B

Fernando Tatis Jr. (R) RF

Luis Arraez (L) DH

Manny Machado (R) 3B

Xander Bogaerts (R) SS

Oscar Gonzalez (R) LF

Yuli Gurriel (R) 1B

Jose Iglesias (R) 2B

Brandon Lockridge (R) CF

Elias Díaz (R) C

Batting Average:  Carson Kelly (.417)

Hits:  Kyle Tucker (23)

Home Runs:  Kyle Tucker (5)

RBI:  Kyle Tucker (18)

Stolen Bases:  Pete Crow-Armstrong (6)

Wins:  Justin Steele (3)

Saves:  Ryan Pressly (4)

ERA:  Ethan Roberts (0.00)

Batting Average:  Jackson Merrill (.378)

Hits:  Fernando Tatis (20)

Home Runs:  Fernando Tatis (4)

RBI:  Jackson Merrill (10)

Stolen Bases:  Fernando Tatis (6)

Wins:  Michael King (3)

Saves:  Robert Suarez (7)

ERA:  Jason Adam (0.00)

Managers:

Chicago Cubs: Craig Counsell (2nd season)

San Diego Padres: Mike Shildt (2nd season)