Chicago Cubs vs New York Yankees Prediction, Preview and Odds - 07/12/2025

Game Time: 1:05 pm ET, Saturday, July 12, 2025

Venue:  Yankee Stadium, Bronx, NY

Where to Watch:  MLBN

DraftKings:  Moneyline odds:  Cubs +140, Yankees -172; Over/Under:  8.5 runs

Bet365:  Moneyline odds:  Cubs +140, Yankees -170; Over/Under:  8.5 runs

BetMGM:  Moneyline odds:  Cubs +140, Yankees -170; Over/Under:  8.5 runs

Chicago Cubs:  55-38 (1st place, NL Central)

New York Yankees:  52-41 (2nd place, AL East)

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Chicago Cubs:  6-4 last 10

New York Yankees:  4-6 last 10

The Cubs are entering this series off a win and lost their 3-game series against the Minnesota Twins 2-1 in their last series. They enter this game with a 55-38 record overall and have a road record of 25-22. This is the 2nd game of a 3-game series with the Yankees on Saturday with the series opener still to be played on Friday. Their offense ranks 3rd in the MLB with a .774 OPS. Chris Flexen is their starting pitcher on Friday while Matthew Boyd is making his start in this game on Saturday. He is 9-3 with a 2.52 ERA this season. His team won their last 3 straight games this season with him making an appearance. In his last MLB regular season start, he allowed 0 ER, 0 HR, and 1 BB with 9 SO on 3 hits through 5 IP against the St Louis Cardinals.

The Yankees are entering this series off a win and completed the sweep in their 3-game series against the Seattle Mariners 3-0 in their last series. They enter this game with a 52-41 record overall and have a home record of 29-17. This is the 2nd game of a 3-game series with the Cubs on Saturday with the 1st game of this series still to be played on Friday. Their offense ranks 1st in the MLB with a .793 OPS. Carlos Rodón is their starting pitcher on Friday while Max Fried is making his start in this game on Saturday. He is 11-2 with a 2.27 ERA this season. His team won 2 of their last 3 games this season with him making an appearance. In his last MLB regular season start, he allowed 3 earned runs, 0 homers, and 1 walk with 5 strikeouts on 6 hits through 5 innings pitched against the New York Mets.

The current betting odds have the Yankees listed as a favorite in this game according to Draftkings Sportsbook. The Yankees have looked really good in their games this season with their 52-41 record overall which has them right near the top of the AL East. They have also looked great in their own ballpark this year with their 29-17 home record. Meanwhile, the Cubs have looked great in their games this season with their 55-38 record overall which has them right at the top of the NL Central with one of the best records in the entire MLB. They have been a good road team too with their 25-22 road record this season. The Cubs are 6-4 in their last 10 games while the Yankees are only 4-6, but the Cubs did lose their last series to the Twins as they are cooling off while the Yankees just swept the Mariners and are getting hot again. The Cubs are going to have Boyd on the mound here and he has looked great this season. He is 9-3 with a 2.52 ERA and is coming off another great start in which he gave up no runs. His team has also won 3 games in a row with him starting. The Yankees are going with Fried in this one and he has pretty much been their ace this season. He is 11-2 with a 2.27 ERA and hasn't been giving up many runs all year. He did give up 3 earned runs in his last start, but that hasn't been a common theme for him and the team has still won 2 of their last 3 games with him starting. Both of these starters have been great and both have great offenses too, but the Yankees are starting to turn the corner while the Cubs are going into a mini slump so the Yankees have the edge in this one at home. The best way to place a bet here is on the Yankees to win this game. 

Cubs Yankees Prediction:  Our MLB Pick for Saturday, July 12, 2025 (1:05 pm ET start time) is Yankees 5 Cubs 4.

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Chicago Cubs: 17-13 (+5.8 units) on the moneyline against AL East opponents. 222-195 (+14.6 units) on the moneyline in all games. 68-49 (+18.2 units) on the moneyline in an inter-league game. 24-13 OVER on the road when playing against a good team (Win Pct. 54% to 62%).

New York Yankees: 20-19 (-8.5 units) on the moneyline against NL Central opponents. 235-195 (-25.2 units) on the moneyline in all games. 119-96 (-25.2 units) on the moneyline in home games. 13-5 OVER at home against NL Central opponents.

Chicago Cubs:  P. Hodge (RP) Fifteen Day IL - Shoulder. J. Taillon (SP) Fifteen Day IL - Calf. M. Amaya (C) Ten Day IL - Oblique. E. Morgan (RP) Sixty Day IL - Elbow. J. Assad (RP) Sixty Day IL - Oblique. J. Steele (SP) Sixty Day IL - Elbow.

New York Yankees:  M. Leiter Jr. (RP) Fifteen Day IL - Fibular. C. Schmidt (SP) Fifteen Day IL - Forearm. F. Cruz (RP) Fifteen Day IL - Oblique. R. Yarbrough (SP) Fifteen Day IL - Oblique. Y. De Los Santos (RP) Fifteen Day IL - Elbow. O. Cabrera (3B) Sixty Day IL - Ankle. J. Cousins (RP) Sixty Day IL - Elbow. L. Gil (SP) Sixty Day IL - Back. G. Cole (SP) Sixty Day IL - Elbow.

“You’re going to have a couple days like that from time to time. But kind of be the guy that drives the bus the next day.” - Craig Counsell after his team’s win against the Twins in their game on Thursday.

“Baseball is funny like that. The guys didn’t give up. Just keep grinding at-bats.” - Aaron Boone after his team’s win against the Mariners in their game on Thursday.

Ian Happ (S) LF

Kyle Tucker (L) DH

Seiya Suzuki (R) RF

Pete Crow-Armstrong (L) CF

Michael Busch (L) 1B

Dansby Swanson (R) SS

Carson Kelly (R) C

Nico Hoerner (R) 2B

Matt Shaw (R) 3B

Jasson Domínguez (S) LF

Trent Grisham (L) CF

Aaron Judge (R) DH

Cody Bellinger (L) RF

Jazz Chisholm Jr. (L) 2B

Ben Rice (L) 1B

Austin Wells (L) C

Anthony Volpe (R) SS

Jorbit Vivas (L) 3B

Batting Average:  Michael Busch (.296)

Hits:  Pete Crow-Armstrong (98)

Home Runs:  Seiya Suzuki (25)

RBI:  Seiya Suzuki (77)

Stolen Bases:  Pete Crow-Armstrong (27)

Wins:  Matthew Boyd (9)

Saves:  Daniel Palencia (10)

ERA:  Michael Fulmer (0.00)

Batting Average:  Aaron Judge (.356)

Hits:  Aaron Judge (122)

Home Runs:  Aaron Judge (34)

RBI:  Aaron Judge (78)

Stolen Bases:  Jasson Domínguez (14)

Wins:  Max Fried (11)

Saves:  Devin Williams (13)

ERA:  Adam Ottavino (0.00)

Managers:

Chicago Cubs: Craig Counsell (2nd season)

New York Yankees: Aaron Boone (8th season)