Chicago Cubs vs Milwaukee Brewers Prediction, Preview and Odds - 09/08/2026

Game Time: 7:40 pm ET, Tuesday, September 8, 2026

Venue:  American Family Field, Milwaukee, WI 

Where to Watch:  MLB TV

DraftKings:  Moneyline odds:  Cubs +177, Brewers -217; Over/Under:  7 runs

Bet365:  Moneyline odds:  Cubs +180, Brewers -225; Over/Under:  7.5 runs

BetMGM:  Moneyline odds:  Cubs +180, Brewers -225; Over/Under:  7.5 runs

Chicago Cubs:  81-63 (2nd place, NL Central)

Milwaukee Brewers:  88-56 (1st place, NL Central)

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Chicago Cubs:  5-5 last 10

Milwaukee Brewers:  5-5 last 10

The Cubs are entering this series off a loss and won their 3-game series against the Miami Marlins 2-1 in their last series. They enter this game with an 81-63 record overall and have a road record of 40-32. This is the 2nd game of a 3-game series with the Brewers on Tuesday with the series opener still to be played on Monday. Their offense ranks 1st in the MLB with a .770 OPS. Matthew Boyd is their starting pitcher on Monday while David Peterson is making his start in this game on Tuesday. He is 7-8 with a 5.39 ERA this season. His team lost their last 3 straight games this season with him making an appearance. In his last MLB regular season appearance, he allowed 6 ER, 1 HR, and 4 BB with 4 SO on 7 hits through 3.2 IP against the Milwaukee Brewers.

The Brewers are entering this series off a loss and lost their 3-game series against the Cincinnati Reds 2-1 in their last series. They enter this game with an 88-56 record overall and have a home record of 47-25. This is the 2nd game of a 3-game series with the Cubs on Tuesday with the 1st game of this series still to be played on Monday. Their offense ranks 5th in the MLB with a .738 OPS. Robert Gasser is their starting pitcher on Monday while Jacob Misiorowski is making his start in this game on Tuesday. He is 14-5 with a 1.97 ERA this season. His team won their last 5 straight games this season with him making an appearance. In his last MLB regular season start, he allowed 5 earned runs, 1 homer, and 4 walks with 5 strikeouts on 5 hits through 4 innings pitched against the Chicago Cubs.

The current betting odds have the Brewers listed as a big favorite in this game according to Draftkings Sportsbook. The Brewers have looked great in their games this season with their 88-56 record overall which has them right at the top of the NL Central with the best record in MLB. They have looked great in their own ballpark too with their 47-25 home record this season. Meanwhile, the Cubs have looked really good in their games this season with their 81-63 record overall which has them right near the top of the NL Central. They have been a good road team too with their 40-32 road record this year. The Brewers are only 5-5 in their last 10 games and they haven't looked great lately, but the Cubs are also 5-5 in their last 10 games and haven't looked any better. The Cubs do have one of the best offenses in MLB, but the Brewers aren't far behind them and the Brewers are going to have the better pitching matchup in this one. The Brewers are going with Misiorowski in this one and he has looked great this season. He is 14-5 with a 1.97 ERA and he has been their ace this year, being one of the best starters in the entire league. He did give up 5 earned runs in his last start, but that hasn't been a common theme for him this year and the team has still won 5 games in a row with him starting, having a ton of success with him all year. The Cubs are going with Peterson in this one and he hasn't looked great this season. He is 7-8 with a 5.39 ERA and he has been giving up a lot of runs lately. He is coming off another bad start giving up 6 earned runs which has been a common theme for him and the team has been having trouble with him lately too, losing 3 games in a row now with him starting. All signs are pointing to the Brewers at home with this pitching matchup and they do have the stronger bullpen to lean on too. The best way to place a bet here is on the Brewers to win this game and on the runline. 

Cubs Brewers Prediction:  Our MLB Pick for Tuesday, September 8, 2026 (7:40 pm ET start time) is Brewers 5 Cubs 1.

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Chicago Cubs: 65-68 (-14.6 units) on the moneyline when the total is 7 to 7.5. 77-74 (-7.3 units) on the moneyline against division opponents. 37-46 (-10 units) on the moneyline when playing against a good team (Win Pct. 54% to 62%). 20-11 OVER as a road underdog of +100 or higher.

Milwaukee Brewers: 282-199 (+51.5 units) on the moneyline in all games. 149-92 (+25.3 units) on the moneyline in home games. 182-110 (+23.7 units) on the moneyline as a favorite of -110 or higher. 9-3 OVER vs. an NL starting pitcher whose ERA is 5.40 or worse.

Chicago Cubs:  I. Happ (LF) Day To Day - Knee. J. Webb (RP) Day To Day - Forearm. P. Maton (RP) Sixty Day IL - Knee. E. Cabrera (SP) Fifteen Day IL - Blister. D. Swanson (SS) Ten Day IL - Side. B. Brown (RP) Sixty Day IL - Neck. G. Hollowell (RP) Fifteen Day IL - Shoulder. R. Martin (RP) Sixty Day IL - Elbow. P. Hodge (RP) Sixty Day IL - Elbow. C. Horton (SP) Sixty Day IL - Forearm. H. Harvey (RP) Sixty Day IL - Tricep. J. Steele (SP) Sixty Day IL - Elbow. T. Austin (1B) Sixty Day IL - Knee. S. Miller (RP) Sixty Day IL - Elbow.

Milwaukee Brewers:  G. Anderson (RP) Fifteen Day IL - Biceps. B. Wilson (RP) Fifteen Day IL - Back. R. Zastryzny (RP) Sixty Day IL - Shoulder. B. Woodruff (SP) Sixty Day IL - Shoulder. Q. Priester (SP) Sixty Day IL - Wrist. B. Fitzpatrick (RP) Sixty Day IL - Elbow. A. Zerpa (RP) Sixty Day IL - Forearm.

“It’s a big round number and it’s a symbolic number. Forty home runs – it's a hard number to get to and not many guys ever get to it in their career, so it was cool to see, and [the] season's not over. He's got more to add to the number.” - Craig Counsell on PCA after his team’s loss against the Marlins in their game on Sunday. 

“It’s a daunting task if you keep getting short starts like that. At some point, we’ll come up for air. This team has been resilient all year long. I believe they’ll bounce back. Just when you count them out, you look up and go, ‘God, we’re doing pretty good’. I believe in it.” - Pat Murphy after his team’s loss against the Reds in their game on Sunday. 

Pete Crow-Armstrong (L) CF

Seiya Suzuki (R) DH

Alex Bregman (R) 3B

Tyrone Taylor (R) LF

Nico Hoerner (R) SS

Matt Shaw (R) RF

Carson Kelly (R) C

BJ Murray Jr. (S) 1B

Pedro Ramírez (S) 2B

Jackson Chourio (R) LF

Brice Turang (L) 2B

William Contreras (R) C

Andrew Vaughn (R) 1B

Christian Yelich (L) DH

Luis Lara (S) RF

Cooper Pratt (R) SS

Garrett Mitchell (L) CF

Joey Ortiz (R) 3B

Batting Average:  Gabriel Arias (.429)

Hits:  Pete Crow-Armstrong (155)

Home Runs:  Pete Crow-Armstrong (40)

RBI:  Pete Crow-Armstrong (96)

Stolen Bases:  Pete Crow-Armstrong (33)

Wins:  Shota Imanaga (9)

Saves:  Jacob Webb (9)

ERA:  Ty Blach (0.00)

Batting Average:  Jihwan Bae (.500)

Hits:  William Contreras (138)

Home Runs:  Jake Bauers (24)

RBI:  Brice Turang (85)

Stolen Bases:  David Hamilton (27)

Wins:  Jacob Misiorowski (14)

Saves:  Trevor Megill (26)

ERA:  Easton McGee (0.00)

Managers:

Chicago Cubs: Craig Counsell (3rd season)

Milwaukee Brewers: Pat Murphy (3rd season)