Chicago Cubs vs Milwaukee Brewers Prediction, Preview and Odds - 06/27/2026

Game Time: 7:10 pm ET, Saturday, June 27, 2026

Venue:  American Family Field, Milwaukee, WI 

Where to Watch:  MLB TV

DraftKings:  Moneyline odds:  Cubs +135, Brewers -165; Over/Under:  8 runs

Bet365:  Moneyline odds:  Cubs +135, Brewers -165; Over/Under:  8 runs

BetMGM:  Moneyline odds:  Cubs +135, Brewers -165; Over/Under:  8 runs

Chicago Cubs:  44-37 (2nd place, NL Central)

Milwaukee Brewers:  49-29 (1st place, NL Central)

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Chicago Cubs:  7-3 last 10

Milwaukee Brewers:  7-3 last 10

The Cubs are entering this series off a win and completed the sweep in their 4-game series against the New York Mets 4-0 in their last series. They enter this game with a 44-37 record overall and have a road record of 21-20. This is the 2nd game of a 3-game series with the Brewers on Saturday with the series opener still to be played on Friday. Their offense ranks 6th in the MLB with a .740 OPS. Colin Rea is their starting pitcher on Friday while David Peterson is making his start in this game on Saturday. He is 3-6 with a 6.09 ERA this season. His team lost their last 3 straight games this season with him making an appearance. In his last MLB regular season appearance, he allowed 4 ER, 1 HR, and 2 BB with 5 SO on 6 hits through 4 IP against the Philadelphia Phillies.

The Brewers are entering this series off a win and completed the sweep in their 3-game series against the Cincinnati Reds 3-0 in their last series. They enter this game with a 49-29 record overall and have a home record of 25-15. This is the 2nd game of a 3-game series with the Cubs on Saturday with the 1st game of this series still to be played on Friday. Their offense ranks 10th in the MLB with a .729 OPS. Jacob Misiorowski is their starting pitcher on Friday while Kyle Harrison is making his start in this game on Saturday. He is 8-1 with a 2.50 ERA this season. His team won 10 of their last 11 games this season with him making an appearance. In his last MLB regular season start, he allowed 2 earned runs, 1 homer, and 0 walks with 7 strikeouts on 4 hits through 6.1 innings pitched against the Atlanta Braves.

The current betting odds have the Brewers listed as a favorite in this game according to Draftkings Sportsbook. The Brewers have looked great in their games this season with their 49-29 record overall which has them right at the top of the NL Central with one of the best records in MLB. They have looked great in their own ballpark too with their 25-15 home record this season. Meanwhile, the Cubs have looked good in their games this season with their 44-37 record overall which has them right near the top of the NL Central. They haven't been a great road team though with their 21-20 road record this year. Both of these teams are 7-3 in their last 10 games respectively and have been rolling lately. The Cubs just swept the Mets in their last series and have one of the best offenses in MLB that is starting to get hot again, but the Brewers do have a really good offense themselves that has also been getting hot lately. As hot as they have been lately, the Cubs do have a lot of injuries to pitchers that they are dealing with, so they aren't going to have the best option on the mound in this one while the Brewers have a big edge with their starter and bullpen. Harrison is on the mound for the Brewers in this one and he has looked great this season. He is 8-1 with a 2.50 ERA and the team has been having a ton of success with him lately. They have won 10 of their last 11 games with him starting now and he is coming off another great start in which he gave up 2 earned runs, something that has been a common theme for him. The Cubs just beat up on a bad Mets team, but the Brewers are a completely different animal with one of the best records in MLB at the moment, so look for the Brewers to take advantage of this pitching matchup and take a bigger lead over the Cubs in this division. The best way to place a bet here is on the Brewers to win this game.

Cubs Brewers Prediction:  Our MLB Pick for Saturday, June 27, 2026 (7:10 pm ET start time) is Brewers 6 Cubs 2.

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Chicago Cubs: 63-62 (-6 units) on the moneyline against division opponents. 148-139 (-6.4 units) on the moneyline vs. good fielding teams - averaging 0.6 errors/game or less. 27-36 (-10.2 units) on the moneyline vs. NL teams allowing 4.0 or less runs/game on the season. 26-17 OVER vs. an NL team with a team batting average of .255 or worse.

Milwaukee Brewers: 243-172 (+49.5 units) on the moneyline in all games. 127-82 (+19.3 units) on the moneyline in home games. 77-46 (+24.4 units) on the moneyline against division opponents. 4-1 OVER vs. an NL starting pitcher whose ERA is 5.40 or worse.

Chicago Cubs:  B. Brown (RP) Fifteen Day IL - Neck. E. Cabrera (SP) Fifteen Day IL - Hamstring. D. Palencia (RP) Fifteen Day IL - Elbow. J. Taillon (SP) Fifteen Day IL - Hamstring. R. Martin (RP) Sixty Day IL - Elbow. P. Hodge (RP) Sixty Day IL - Elbow. C. Horton (SP) Sixty Day IL - Forearm. H. Harvey (RP) Sixty Day IL - Tricep. J. Steele (SP) Sixty Day IL - Elbow. T. Austin (1B) Sixty Day IL - Knee. S. Miller (RP) Sixty Day IL - Elbow.

Milwaukee Brewers:  Q. Priester (SP) Sixty Day IL - Wrist. C. Crow (SP) Fifteen Day IL - Forearm. B. Fitzpatrick (RP) Sixty Day IL - Elbow. C. Rodriguez (RP) Fifteen Day IL - Shoulder. D. Hall (RP) Fifteen Day IL - Pectoral. R. Zastryzny (RP) Fifteen Day IL - Shoulder. A. Zerpa (RP) Sixty Day IL - Forearm. L. Henderson (SP) Fifteen Day IL - Back. B. Lockridge (LF) Ten Day IL - Knee. J. Koenig (RP) Fifteen Day IL - Elbow.

“We asked a lot of everybody in this series. When you are playing good baseball, there are a lot of names to mention. That was absolutely the case in the last four days and tonight as well.” - Craig Counsell after his team’s win against the Mets in their game on Thursday.

"The pieces fit easily. This is a kid that we've signed for [the] long-term [in] Cooper. We feel confident that he will be our shortstop of the future, and he's going to play. But Joey [Ortiz] is a huge part of our organization [and] has been. We will never forget what he's done for us at shortstop and can do at shortstop again. But he also can play third [and] he can play second." - Pat Murphy on calling up Cooper Pratt.

Pete Crow-Armstrong (L) CF

Michael Conforto (L) RF

Michael Busch (L) 1B

Alex Bregman (R) 3B

Ian Happ (S) LF

Nico Hoerner (R) 2B

Pedro Ramírez (S) DH

Miguel Amaya (R) C

Dansby Swanson (R) SS

Christian Yelich (L) DH

Jackson Chourio (R) LF

Brice Turang (L) 2B

William Contreras (R) C

Jake Bauers (L) 1B

Garrett Mitchell (L) CF

Sal Frelick (L) RF

Cooper Pratt (R) SS

David Hamilton (L) 3B

Batting Average:  Justin Dean (.667)

Hits:  Pete Crow-Armstrong (88)

Home Runs:  Pete Crow-Armstrong (17)

RBI:  Dansby Swanson (46)

Stolen Bases:  Pete Crow-Armstrong (18)

Wins:  Javier Assad (6)

Saves:  Daniel Palencia (3)

ERA:  Ty Blach (0.00)

Batting Average:  Andrew Vaughn (.351)

Hits:  William Contreras (87)

Home Runs:  Jake Bauers (14)

RBI:  Jake Bauers (48)

Stolen Bases:  David Hamilton (16)

Wins:  Aaron Ashby (10)

Saves:  Trevor Megill (10)

ERA:  Jared Koenig (0.00)

Managers:

Chicago Cubs: Craig Counsell (3rd season)

Milwaukee Brewers: Pat Murphy (3rd season)