by Rod Pearson
Thursday, Dec 11, 2025
Game Time: 4:25 pm ET, Sunday, December 14, 2025
Venue: Caesars Superdome, New Orleans, LA
Where to Watch: FOX
Opening Odds at USA Sportsbooks
DraftKings: Point Spread: Panthers -3, Saints +3; Over/Under: 40.5 points
Bet365: Point Spread: Panthers -2.5, Saints +2.5; Over/Under: 40.5 points
BetMGM: Point Spread: Panthers -2.5, Saints +2.5; Over/Under: 40.5 points
Season Record
Carolina Panthers: 7-6 (2nd place, NFC South)
New Orleans Saints: 3-10 (4th place, NFC South)
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Recent Form
Carolina Panthers: won their last game at home against the Los Angeles Rams 31-28.
New Orleans Saints: won their last game on the road against the Tampa Bay Buccaneers 24-20.
Carolina Panthers vs New Orleans Saints Preview and Analysis
The Panthers are entering this game with a 7-6 record overall and they have a 2-1 record in their divisional games too. They are 4-2 in their home games, 3-4 in their road games, and they are also 0-0 in their neutral site games this season, but they will be on the road for this game. They won their last game against the Los Angeles Rams 31-28. Bryce Young was the starting QB and he completed 15/20 passes for 206 passing yards, 3 touchdowns, and 0 interceptions. Chuba Hubbard led the team in rushing yards with 83. Jalen Coker led the receivers with 74 receiving yards on 4 receptions and 1 TD. Nick Scott led the defense in that game with 5 solo tackles and 4 assisted tackles while Lathan Ransom and Derrick Brown each led the defense in sacks with 1. Nick Scott and Mike Jackson each came away with 1 interception for them in that one.
The Saints are entering this game with a 3-10 record overall and they have a 2-2 record in their divisional games too. They are 1-5 in their home games, 2-5 in their road games, and they are also 0-0 in their neutral site games this season, but they will be at home for this game. They won their last game against the Tampa Bay Buccaneers 24-20. Tyler Shough was the starting QB and he completed 13/20 passes for 144 passing yards, 0 touchdowns, and 1 interception. Devin Neal led the team in rushing yards with 70 and 1 TD. Devaughn Vele led the receivers with 40 receiving yards on 3 receptions. Kool-Aid McKinstry led the defense in that game with 6 solo tackles and 1 assisted tackle while no one on the defense recorded a sack for them. Alontae Taylor came away with the only interception for them in that one.
Panthers vs Saints Prediction
The current betting odds have the Panthers listed as a 3 point favorite in this game according to Draftkings Sportsbook. The Panthers have looked good in their games this season with their 7-6 record overall which has them right near the top of the NFC South. They haven't been a great road team though with their 3-4 road record this year. Meanwhile, the Saints have looked terrible in their games this season with their 3-10 record overall which has them right at the bottom of the NFC South. They have looked terrible on their home field too with their 1-5 home record this year. The Saints have been one of the worst teams in the NFL this year, but lately they have looked a lot better with Tyler Shough taking over. He has picked up 2 wins in his starts, coming off a 24-20 road win over the Bucs in their last one, but they haven't been a consistent team this year so it is tough to see them following that win up with another. The Panthers are off a 31-28 win over the Rams in their last one and they have been gaining momentum lately with the division still up for grabs. The Panthers have a chance to win the NFC South with only 4 games left in the season so they are going to bring their best effort to keep those hopes alive, and they still owe the Saints some payback after losing at home to them a few weeks ago. The best way to place a bet here is on the Panthers to cover the spread in this game.
Panthers Saints Prediction: Our NFL Pick for Sunday, December 14, 2025 (4:25 pm ET start time) is Panthers 27 Saints 20.
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NFL Betting Trends
Carolina Panthers: 22-15 ATS off an upset win as a home underdog. 44-26 ATS revenging a home loss against an opponent. 38-16 ATS vs. poor offensive teams - scoring 17 or less points/game. 5-1 UNDER versus division opponents. 3-0 UNDER vs. poor offensive teams - scoring 17 or less points/game.
New Orleans Saints: 18-28 ATS in all games. 2-9 ATS as a home underdog of 7 points or less. 9-16 ATS in dome games. 29-18 UNDER in all games. 17-8 UNDER in all games where the total is between 35.5 and 42 points.
Key Injuries
Carolina Panthers: C. Cherelus (LB) Injured - Concussion. C. Mays (C) Injured - Ankle. J. Horn (CB) Injured - Concussion. C. Rozeboom (LB) Injured - Hip. L. Ransom (S) Injured - Thumb.
New Orleans Saints: A. Kamara (RB) Injured - Knee. J. Reid (S) Injured - Knee. C. Rumph II (DL) Injured - Wrist. A. Richards (OG) Injured - Ankle. T. Fuaga (OT) Injured - Ankle. D. Neal (RB) Injured - Abdomen.
Notable Quotes
“Nobody gave us a shot all week. It's been that way since we were 1/3 when everybody outside of this locker room was like, ‘here we go again.’ Many people didn't see the vision but we knew if we would just kept working we would have those opportunities.” - Derrick Brown after their win against the LA Rams in their last game.
“Our guys have a lot of adversity this year and they’ve grown through this journey.” - Kellen Moore after his team’s win against the Buccaneers in their last game.
Starting Lineups
Carolina Panthers
WR McMillan, Tetairoa
WR Legette, Xavier
WR Coker, Jalen
TE Tremble, Tommy
QB Young, Bryce
RB Dowdle, Rico
New Orleans Saints
WR Tipton, Mason
WR Vele, Devaughn
WR Olave, Chris
TE Johnson, Juwan
QB Shough, Tyler
RB Neal, Devin
Statistical Leaders
Carolina Panthers
Passing: Bryce Young (2,337)
Rushing: Rico Dowdle (929)
Receiving: Tetairoa McMillan (826)
Touchdowns: Rico Dowdle (6)
New Orleans Saints
Passing: Spencer Rattler (1,586)
Rushing: Alvin Kamara (471)
Receiving: Chris Olave (811)
Touchdowns: Chris Olave (5)
Coaches:
Carolina Panthers: Dave Canales (2nd season)
New Orleans Saints: Kellen Moore (1st season)
Rod Pearson
About the Author:
Rod Pearson has been a rabid sports fan his entire life. He grew up in Ontario, and was skilled in both hockey and baseball, and pitched in an elite baseball league for many years. In 2022, Rod decided to hang up his glove, so that he could write about the sports he loves -- but from a gambling perspective. Join Rod every day as he breaks down the games to find the best betting value.
