by Rod Pearson
Thursday, Oct 30, 2025
Game Time: 1:00 pm ET, Sunday, November 2, 2025
Venue: Lambeau Field, Green Bay, WI
Where to Watch: FOX
Opening Odds at USA Sportsbooks
DraftKings: Point Spread: Panthers +13.5, Packers -13.5; Over/Under: 44.5 points
Bet365: Point Spread: Panthers +13, Packers -13; Over/Under: 44 points
BetMGM: Point Spread: Panthers +13.5, Packers -13.5; Over/Under: 44 points
Season Record
Carolina Panthers: 4-4 (2nd place, NFC South)
Green Bay Packers: 5-1-1 (1st place, NFC North)
Do not miss out on our expert handicapper analysis! Tom Stryker is on a HOT STREAK in the NFL on a 7-0 NFL RUN for +$7,000 PROFIT! Make sure you check out his picks and many more from the expert handicappers featured in the Shop Picks section.
Recent Form
Carolina Panthers: lost their last game at home against the Buffalo Bills 40-9.
Green Bay Packers: won their last game on the road against the Pittsburgh Steelers 35-25.
Carolina Panthers vs Green Bay Packers Preview and Analysis
The Panthers are entering this game with a 4-4 record overall and they have a 1-0 record in their divisional games too. They are 3-1 in their home games, 1-3 in their road games, and they are also 0-0 in their neutral site games this season, but they will be on the road for this game. They lost their last game against the Buffalo Bills 40-9. Andy Dalton was the starting QB and he completed 16/24 passes for 175 passing yards, 0 touchdowns, and 1 interception. Rico Dowdle led the team in rushing yards with 54. Tetairoa McMillan led the receivers with 99 receiving yards on 7 receptions. Christian Rozeboom led the defense in that game with 7 solo tackles and 5 assisted tackles while Trevin Wallace led the defense in sacks with 1. No one on the defense came away with an interception for them in that one.
The Packers are entering this game with a 5-1-1 record overall and they have a 1-0 record in their divisional games too. They are 3-0 in their home games, 2-1-1 in their road games, and they are also 0-0 in their neutral site games this season, but they will be at home for this game. They lost their last game against the Pittsburgh Steelers 35-25. Jordan Love was the starting QB and he completed 29/37 passes for 360 passing yards, 3 touchdowns, and 0 interceptions. Emanuel Wilson led the team in rushing yards with 61. Tucker Kraft led the receivers with 143 receiving yards on 7 receptions and 2 TDs. Xavier McKinney led the defense in that game with 6 solo tackles and 1 assisted tackle while Rashan Gary led the defense in sacks with 2. No one on the defense came away with an interception for them in that one.
Panthers vs Packers Prediction
The current betting odds have the Packers listed as a 13.5 point favorite in this game according to Draftkings Sportsbook. The Packers have looked great in their games this season with their 5-1-1 record overall which has them right at the top of the NFC North with one of the best records in the entire NFL. They are off a 35-25 win over the Steelers in their last one and they are starting to roll now with 3 wins in a row. Meanwhile, the Panthers haven't looked great in their games this season with their 4-4 record overall, but that record has them right near the top of the NFC South. They have shown a lot of improvement this season, but they haven't been a good road team with their 1-3 road record. They are also off a 40-9 loss at home to the Bills in their last one and they are going to have Bryce Young back for this game, but it's not going to matter much on the road against one of the best teams in the NFL. The Panthers defense has looked better against bad teams in recent weeks, but that defense is still a big issue and this Packers offense is going to have their way with the Panthers defense at home. The Panthers don't have the most consistent offense either so all signs point to them getting blown out again by a much better team. The best way to place a bet here is on the Packers to cover the spread in this game.
Panthers Packers Prediction: Our NFL Pick for Sunday, November 2, 2025 (1:00 pm ET start time) is Packers 34 Panthers 10.
Don't miss our champion handicappers free picks and expert football picks today. And if you enjoyed this Carolina Panthers Green Bay Packers prediction, be sure to drop by every day for our weekly NFL predictions and previews.
NFL Betting Trends
Carolina Panthers: 5-14 ATS as a road underdog. 5-10 ATS after allowing 30 points or more last game. 2-9 ATS when playing against a team with a winning record. 7-2 OVER in a road game where the total is between 42.5 and 49 points. 9-5 OVER vs. good passing teams averaging 235 or more passing yards/game.
Green Bay Packers: 9-5 ATS in a home game where the total is between 42.5 and 49 points. 9-2 ATS off a road win. 6-2 ATS versus good rushing teams - averaging 130 rushing yards/game or more. 4-1 OVER vs. poor passing teams averaging 5.7 or less passing yards/att.
Key Injuries
Carolina Panthers: T. Moton (OT) Injured - Knee. A. Dalton (QB) Injured - Right Thumb. B. Christensen (OG) Injured - Achilles. D. Brown (DL) Injured - Knee. N. Scott (S) Injured - Groin. C. Mays (C) Injured - Ankle. D. Lewis (OG) Injured - Oblique. B. Young (QB) Injured - Ankle. C. Zavala (OG) Injured - Knee. T. Wallace (LB) Injured - Shoulder. P. Umanmielen (LB) Injured - Ankle. J. Horn Jr. (WR) Injured - Shoulder.
Green Bay Packers: B. McManus (K) Injured - Right Quadricep. Z. Anderson (S) Injured - Calf. N. Niemann (LB) Injured - Pectoral. A. Banks (OG) Injured - Shin. Z. Tom (OG) Injured - Back. D. Wyatt (DL) Injured - Knee. D. Wicks (WR) Injured - Calf. L. Van Ness (DL) Injured - Foot. C. Watson (WR) Injured - Knee.
Notable Quotes
“I just have a lot of confidence in this group and the football that we’ve been playing — and knowing that was not us. What we put out there today was not us. That was not the ball that we’ve been playing that’s allowed us to have a lot of success. Let’s get refocused and let’s get back to work.” - Dave Canales after his team’s loss against the Bills in their last game.
“He was on fire. That’s why we kept wanting to throw the football.” - Matt LaFleur after his team’s win against the Steelers in their last game.
Starting Lineups
Carolina Panthers
WR McMillan, Tetairoa
WR Legette, Xavier
WR Coker, Jalen
TE Sanders, Ja'Tavion
QB Young, Bryce
RB Dowdle, Rico
Green Bay Packers
WR Watson, Christian
WR Doubs, Romeo
WR Golden, Matthew
TE Kraft, Tucker
QB Love, Jordan
RB Jacobs, Josh
Statistical Leaders
Carolina Panthers
Passing: Bryce Young (1,288)
Rushing: Rico Dowdle (605)
Receiving: Tetairoa McMillan (512)
Touchdowns: Rico Dowdle (3)
Green Bay Packers
Passing: Jordan Love (1,798)
Rushing: Josh Jacobs (447)
Receiving: Tucker Kraft (469)
Touchdowns: Josh Jacobs (9)
Coaches:
Carolina Panthers: Dave Canales (2nd season)
Green Bay Packers: Matt LaFleur (7th season)
Rod Pearson
About the Author:
Rod Pearson has been a rabid sports fan his entire life. He grew up in Ontario, and was skilled in both hockey and baseball, and pitched in an elite baseball league for many years. In 2022, Rod decided to hang up his glove, so that he could write about the sports he loves -- but from a gambling perspective. Join Rod every day as he breaks down the games to find the best betting value.
