Buffalo Bills vs Tennessee Titans Prediction, Preview and Odds - 10/18/2021

Game Time: 8:15 pm ET, Monday, October 18, 2021

Venue:  Nissan Stadium, Nashville, TN

Where to Watch:  ESPN

DraftKings:  Point Spread:  Bills -5.5, Titans +5.5; Over/Under:  53.5 points

Bet365:  Point Spread:  Bills -5.5, Titans +5.5; Over/Under:  54 points

BetMGM:  Point Spread:  Bills -5, Titans +5; Over/Under:  54 points

 

Buffalo Bills:  4-1 (1st place, AFC East)

Tennessee Titans:  3-2 (1st place, AFC South)

 

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Buffalo Bills:  won on the road on Oct. 10 against the Kansas City Chiefs 38-20.

Tennessee Titans:  won on the road on Oct. 10 against the Jacksonville Jaguars 37-19.

 

 

 

The Bills are coming into this game with a 4-1 record overall and they are 2-0 in their road games this season where they will be in this game. After losing their season opener to the Pittsburgh Steelers, the Bills have bounced back winning their last 4 games straight. They have scored over 35 points in all of those wins and are coming off of a massive 38-20 win over the Kansas City Chiefs on Sunday night football. Josh Allen played a great game in that one as he completed 15/26 passes for 315 yards and 3 touchdowns. He also led the team in rushing with 59 yards and 1 touchdown on 11 carries. Zach Moss had 11 carries for 37 yards while Devin Singletary had 6 carries for 25 yards. Dawson Knox had a big game as he led the receivers with 117 yards and 1 touchdown on 3 receptions. Stefon Diggs had 2 catches for 69 yards while Emmanuel Sanders caught 2 touchdown passes for 54 yards on 2 receptions in that game. Taron Johnson led the defense with 8 solo tackles and 4 assisted ones while A.J. Klein was right behind him with 8 solo tackles and 1 assisted one. Gregory Rousseau led the defense in sacks with 1 while Carlos Basham Jr. and Jerry Hughes both combined for 1 in that game. Rousseau also had 1 interception for them in that one along with Micah Hyde. They have scored 172 points in their first 5 games averaging 34.4 PPG and they have allowed their opponents to score 64 points against them allowing 12.8 PPG. Their offense is averaging 410.4 YPG while their defense is allowing 251.8 YPG.

 

 

The Titans are coming into this game with a 3-2 record overall and they are 1-1 in their home games this season where they will be in this game. After a terrible loss to the winless New York Jets, they bounced back in their last game with a win over the Jags 37-19. That game was back and forth to start but the Titans had gained a lead by halftime and never looked back once in that game. Ryan Tannehill played alright as he completed 14/22 passes for 197 yards and 1 touchdown. Derrick Henry had a great day on the ground as he led the team in rushing with 130 yards and 3 touchdowns on 29 carries but he was basically their entire running game in that one. Marcus Johnson led the receivers with 52 yards on 3 receptions while A.J. Brown had 3 catches for 38 yards. David Long led the defense with 10 solo tackles and 2 assisted ones while Kevin Byard was right behind with 8 solo tackles and 2 assisted ones. Harold Landry and Dane Cruikshank also played well in that game with 6 solo tackles and 1 assisted one each. Landry had the only 2 sacks in that game for the defense while Byard had the only interception. They have scored 132 points in their first 5 games averaging 26.4 PPG and they have allowed their opponents to score 130 points against them allowing 26 PPG. Their offense is averaging 389.2 YPG while their defense is allowing 377.4 YPG.

 

 

The Bills are coming into this game as a 5 point favorite with the current betting odds according to Draftkings Sportsbook. They have been playing incredible ever since their loss in their first game of the season. They lead the NFL in points per game and points allowed per game while they are also leading the league in yards allowed per game on defense. The Titans beat up on the winless Jags last week but they lost to the winless Jets the week before. They have some injuries on their side as well but now they are facing a Bills team that is clearly the best team in the AFC right now. The Bills have scored almost 40 points in each of their last 4 games and this game will be no different. The best bet to place in this game is on the Bills to cover the spread here.

 

Bills Titans Prediction:  Our NFL Pick for Monday, October 18, 2021 (8:15 pm ET start time) is Bills 42 Titans 17.

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Buffalo Bills: 240-227 ATS in all games. 112-104 ATS as a favorite. 115-114 ATS in road games. 114-105 ATS off 1 or more straight overs.

Tennessee Titans: 190-202 ATS in all games. 101-103 ATS as an underdog. 91-98 ATS in home games. 132-168 ATS against conference opponents.

 

 

Buffalo Bills:  M. Milano (LB) Ques Mon - Hamstring injury. M. Stevenson (WR) Out indefinitely - Head injury. B. Cox Jr. (DE) Out indefinitely - Achilles injury.

Tennessee Titans:  D. Evans (RB) Ques Mon - Knee injury. B. Breeze (S) Ques Mon - Leg injury. B. Dupree (LB) Ques Mon - Knee injury. B. Kern (P) Ques Mon - Groin injury. J. Jones (WR) Ques Mon - Hamstring injury.

 

 

Buffalo Bills: Dawson Knox is one player to watch in this matchup. He leads his team in touchdowns scored this season. He is coming off of a game where he had over 100 yards receiving and found the end zone as well. He seems to be a big target for Allen in the red zone so look for him to keep playing well in this game and find the end zone as Allen looks for his big body to make the catch.

 

Tennessee Titans: Derrick Henry is one player to watch in this contest. He leads his team in rushing yards and in touchdowns scored this season. He is coming off of a game where he had over 100 rushing yards yet again. He is a beast and has played well in every game this season. He is a focal point of the Titans offense so look for him to keep up his great play as they will indeed him in this game if they are going to have a chance at winning.

 

 

"I think this is going to be made a bigger deal than it is. We're in Week 5. Four wins doesn't get you to the playoffs. We ended up with a win. That's our goal each and every week, to come out and be resilient through lightning delays. I'm proud of how our team handled the situation." - Josh Allen displaying his mentality after a huge win over the Chiefs in their last game in a blowout fashion.

 

 

"I think he's a stud. The crazy thing is, from a rushing standpoint, as an offensive line, we can do way better. We've played way better in the past. We're leaving a lot of meat on the bone there." - Taylor Lewan on Derrick Henry’s performance this season as well as he and his offensive line’s performance.

 

 

 

WR SANDERS, EMMANUEL 

WR Diggs, Stefon 

WR BEASLEY, COLE 

TE Knox, Dawson 

QB Allen, Josh 

RB Singletary, Devin 

FB Gilliam, Reggie 

 

WR JONES, JULIO 

WR Brown, AJ 

WR Reynolds, Josh 

TE Swaim, Geoff 

QB TANNEHILL, RYAN 

RB Henry, Derrick 

 

Passing: J. Allen (1370)

Rushing: D. Singletary (284)

Receiving: S. Diggs (374)

Touchdowns: D. Knox (5)

Sacks: G. Rousseau (3)

Tackles: T. Johnson (21)

 

Passing: R. Tannehill (1251)

Rushing: D. Henry (640)

Receiving: J. Jones (204)

Touchdowns: D. Henry (7)

Sacks: H. Landry III (4.5)

Tackles: H. Landry III (19)

 

Coaches:

Buffalo Bills: Sean McDermott (5th season)

Tennessee Titans: Mike Vrabel (4th season)

 

73 degrees F sunny , 55% humidity, 0% chance of rain, up to 5 mph wind speeds SE.