Buffalo Bills vs New England Patriots Prediction, Preview and Odds - 10/22/2023

Game Time: 1:00 pm ET, Sunday, October 22, 2023

Venue:  Gillette Stadium, Foxborough, MA

Where to Watch:  CBS

DraftKings:  Point Spread:  Bills -9, Patriots +9; Over/Under:  41.5 points

Bet365:  Point Spread:  Bills -8.5, Patriots +8.5; Over/Under:  41.5 points

BetMGM:  Point Spread:  Bills -8.5, Patriots +8.5; Over/Under:  41.5 points

Buffalo Bills:  4-2 (2nd place, AFC East)

New England Patriots:  1-5 (4th place, AFC East)

Do not miss out on our expert handicapper analysis! Al McMordie is on a HOT STREAK in the NFL with 11 Straight Winning NFL Seasons! Make sure you check out his picks and many more from the expert handicappers featured in the Shop Picks section.

Buffalo Bills:  won their last game at home against the New York Giants 14-9.

New England Patriots:  lost their last game on the road against the Las Vegas Raiders 21-17.

The Bills are entering this game with a 4-2 record overall and they have a 1-1 record in their divisional games too. They are 3-0 in their home games, 1-1 in their road games, and they are also 0-1 in their neutral site games this season, but they will be on the road for this game. They won their last game against the New York Giants 14-9. Josh Allen was the starting QB and he completed 19/30 passes for 169 passing yards, 2 touchdowns, and 1 interception. James Cook led the team in rushing yards with 71. Stefon Diggs led the receivers with 100 receiving yards on 10 receptions. Taron Johnson led the defense in that game with 9 solo tackles and 6 assisted tackles while Leonard Floyd and A.J. Epenesa each led the defense in sacks with 1. No one on the defense came away with an interception for them in that game.

 

 

 

The Patriots are entering this game with a 1-5 record overall and they have a 1-1 record in their divisional games too. They are 0-3 in their home games, 1-2 in their road games, and they are also 0-0 in their neutral site games this season, but they will be at home for this game. They lost their last game against the Las Vegas Raiders 21-17. Mac Jones was the starting QB and he completed 24/33 passes for 200 passing yards, 0 touchdowns, and 1 interception. Rhamondre Stevenson led the team in rushing yards with 46 and 1 TD. Kendrick Bourne led the receivers with 89 receiving yards on 10 receptions. Jabrill Peppers led the defense in that game with 7 solo tackles and 0 assisted tackles while no one on the defense recorded a sack in that one. Jahlani Tavai came away with the only interception for them in that game.

The current betting odds have the Bills listed as a 9 point favorite in this game according to Draftkings Sportsbook. The Bills bounced back in their last game at home after losing to the Jaguars in London but they didn't look great in their home win as they only beat the struggling Giants 14-9 in prime time. They will be looking for a much better performance in this game against a divisional opponent and luckily for the Bills, the Patriots have been struggling a lot this year. The Patriots are only 1-5 this season and their offense has struggled a lot just to move the ball and get into scoring positions. They have been on the decline over the last few seasons but this is finally the year where it is all falling apart and the Bills will be looking to take advantage since they do have to compete with the Dolphins this year for the AFC East. The Bills will come out with a better performance in this game and show why they are still the team to beat in this division. The best way to place a bet here is on the Bills to cover the spread in this game. 

Bills Patriots Prediction:  Our NFL Pick for Sunday, October 22, 2023 (1:00 pm ET start time) is Bills 24 Patriots 10.

Don't miss our champion handicappers free picks and expert football picks today. And if you enjoyed this Buffalo Bills New England Patriots prediction, be sure to drop by every day for our weekly NFL predictions and previews.

Buffalo Bills: 9-3 ATS off a non-conference game. 23-13 ATS off a no-cover where the team won as a favorite. 61-34 ATS after 2 or more consecutive losses against the spread. 13-3 UNDER as a road favorite. 13-7 UNDER in road games.

New England Patriots: 5-14 ATS as an underdog. 1-5 ATS in all games. 1-5 ATS off a road loss. 5-1 UNDER in all games. 62-38 UNDER off a road loss. 12-7 UNDER after 1 or more consecutive losses.

Buffalo Bills:  J. Allen (QB) day-to-day - Shoulder. D. Jackson (CB) day-to-day - Foot. D. Harris (RB) day-to-day - Neck. D. Kincaid (TE) day-to-day - Concussion. D. Jones (DT) I-R - Pectoral. M. Milano (LB) I-R - Leg. T. White (CB) I-R - Achilles. J. Shorter (WR) Out indefinitely - Hamstring. T. Doyle (OT) I-R - Knee. Z. Davidson (TE) I-R - Knee. N. Hines (RB) I-R - Knee.

New England Patriots:  K. Boutte (WR) Out indefinitely - Hamstring. C. Strange (OL) day-to-day - Knee. J. Smith-Schuster (WR) day-to-day - Concussion. D. Douglas (WR) day-to-day - Head. R. Reiff (OL) day-to-day - Knee. T. Wheatley Jr. (OT) Out indefinitely - Knee. M. Judon (LB) Early Dec - Bicep. T. Flowers (DE) Out indefinitely - Foot. C. Gonzalez (CB) I-R - Shoulder. D. Ekuale (DL) Out indefinitely - Bicep. M. Jones (DB) Out indefinitely - Shoulder. J. Jones (DB) Out indefinitely - Hamstring. C. Davis (DB) Out indefinitely - Knee. I. Bolden (CB) I-R - Neck. R. McMillan (LB) I-R - Achilles.

“We’re a much better team than we showed tonight, and showed last week. We got to figure out why that is, and how to get ourselves out of a funk early on.” - Josh Allen after their win against the Giants in their last game. 

“Couldn’t quite make enough plays here tonight. Had our opportunities and just need to do a better job here and really just about every area. Any one of the number of things could have made a difference. We just need to coach it better, play it better, execute it a little bit better. That’s really the story again.” - Bill Belichick after his team’s loss against the Raiders in their last game. 

WR Davis, Gabe 

WR Diggs, Stefon 

WR Shakir, Khalil  

TE Knox, Dawson 

QB Allen, Josh 

RB Cook, James 

FB Gilliam, Reggie

WR PARKER, DEVANTE 

WR Thornton, Tyquan  

WR Bourne, Kendrick

TE Henry, Hunter 

QB Jones, Mac 

RB Stevenson, Rhamondre

Passing: J. Allen (1576)

Rushing: J. Cook (363)

Receiving: S. Diggs (620)

Touchdowns: S. Diggs (5)

Passing: M. Jones (1208)

Rushing: R. Stevenson (234)

Receiving: K. Bourne (307)

Touchdowns: K. Bourne (2)

Coaches:

Buffalo Bills: Sean McDermott (7th season)

New England Patriots: Bill Belichick (24th season)