by Rod Pearson
Friday, Oct 16, 2026
Game Time: 4:25 pm ET, Sunday, October 18, 2026
Venue: Allegiant Stadium, Las Vegas, NV
Where to Watch: CBS
Opening Odds at USA Sportsbooks
DraftKings: Point Spread: Bills -5.5, Raiders +5.5; Over/Under: 53.5 points
Bet365: Point Spread: Bills -4.5, Raiders +4.5; Over/Under: 53.5 points
BetMGM: Point Spread: Bills -4.5, Raiders +4.5; Over/Under: 53.5 points
Season Record
Buffalo Bills: 4-1 (1st place, AFC East)
Las Vegas Raiders: 3-2 (3rd place, AFC West)
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Recent Form
Buffalo Bills: won their last game on the road against the Los Angeles Rams 37-34 in overtime.
Las Vegas Raiders: lost their last game on the road against the New England Patriots 45-17.
Buffalo Bills vs Las Vegas Raiders Preview and Analysis
The Bills are entering this game with a 4-1 record overall and they have a 0-1 record in their divisional games too. They are 2-1 in their home games, 2-0 in their road games, and they are also 0-0 in their neutral site games this season, but they will be on the road for this game. They won their last game against the Los Angeles Rams 37-34 in OT. Josh Allen was the starting QB and he completed 12/19 passes for 210 passing yards, 1 touchdown, and 1 interception. Josh Allen led the team in rushing yards with 121 and 1 TD. Khalil Shakir led the receivers with 80 receiving yards on 3 receptions. Cole Bishop led the defense in that game with 11 solo tackles while DeWayne Carter led the defense in sacks with 1. No one on the defense came away with an interception for them in that one.
The Raiders are entering this game with a 3-2 record overall and they have a 1-1 record in their divisional games too. They are 1-1 in their home games, 2-1 in their road games, and they are also 0-0 in their neutral site games this season, but they will be at home for this game. They lost their last game against the New England Patriots 45-17. Kirk Cousins was the starting QB and he completed 19/28 passes for 243 passing yards, 1 touchdown, and 0 interceptions. Ashton Jeanty led the team in rushing yards with 27. Brock Bowers led the receivers with 110 receiving yards on 8 receptions and 1 TD. Nakobe Dean led the defense in that game with 12 solo tackles while Jonah Laulu and Malcolm Koonce each led the defense in sacks with 0.5. No one on the defense came away with an interception for them in that one.
Bills vs Raiders Prediction
The current betting odds have the Bills listed as a 5.5 point favorite in this game according to Draftkings Sportsbook. The Bills have looked great in their games this season with their 4-1 record overall which has them right at the top of the AFC East. They have been a great road team too with their 2-0 road record this year. Meanwhile, the Raiders have looked good in their games this season with their 3-2 record overall which has them right in the middle of the AFC West. They haven't looked great on their home field though with their 1-1 home record this season. The Raiders had a hot start to the season going 3-0, but they have lost 2 games in a row now and have lost all of that momentum. They took their first loss of the season in a tight divisional game against the Chiefs, but now they are coming off a 45-17 loss to the Patriots and they looked lost in that one. That was the first time all season that their offense really struggled and the defense has been a big issue all year with the number of points they have been giving up, now they have to face one of the best offenses in the NFL. The Bills are coming off a 37-34 road win over the Rams in their last one and that win is going to give them a ton of momentum going forward. Their only loss was in a tight divisional game against the Patriots and the Bills have looked like one of the best teams in the NFL through 5 weeks. The Raiders are starting to come back down to Earth now while the Bills have been rolling and that Raiders defense is going to get many stops here. The best way to place a bet here is on the Bills to cover the spread in this game.
Bills Raiders Prediction: Our NFL Pick for Sunday, October 18, 2026 (4:25 pm ET start time) is Bills 34 Raiders 27.
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NFL Betting Trends
Buffalo Bills: 8-4 ATS as a road favorite of 7 points or less. 11-4 ATS when playing against a team with a winning record. 10-1 ATS vs. good offensive teams - scoring 24 or more points/game. 9-4 OVER in all games where the total is greater than or equal to 49.5. 8-4 OVER after a win by 6 or less points.
Las Vegas Raiders: 3-6 ATS as a home underdog of 7 points or less. 1-5 ATS vs. good passing teams averaging 235 or more passing yards/game. 1-7 ATS versus good offensive teams - averaging 5.65 yards/play or more. 9-4 OVER as a home underdog. 15-4 OVER after playing their last game on the road.
Key Injuries
Buffalo Bills: S. Brown (OT) Injured - Back. B. Chubb (LB) Injured - Thumb. D. Moore (WR) Injured - Shoulder. T. Bernard (LB) Injured - Knee. C. Gardner-Johnson (S) Injured - Ankle. E. Oliver (DL) Injured - Knee. T. Johnson (RB) Injured - Hamstring. J. Palmer (WR) Injured - Shoulder. D. Alford (CB) Injured - Ankle. C. Benford (CB) Injured - Toe. K. Coleman (WR) Injured - Ankle. L. Jackson (DL) Injured - Knee. T. Sanders (DL) Injured - Shoulder. T. Parker (LB) Injured - Rib. A. Reed-Adams (OG) Injured - Elbow.
Las Vegas Raiders: S. Olubi (LB) Injured - Wrist. A. Jeanty (RB) Injured - Foot. P. Johnson (DL) Injured - Oblique. J. Nailor (WR) Injured - Concussion. C. Runyon (TE) Injured - Foot. D. Thornton Jr. (WR) Injured - Hamstring. D. Young (WR) Injured - Shoulder. T. Zuhn III (OG) Injured - Knee. B. Bowers (TE) Injured - Knee. S. Burford (OG) Injured - Knee. F. Fatukasi (DL) Injured - Shoulder. T. Hemingway (DL) Injured - Concussion.
Notable Quotes
“The confidence I had in T-Bass was, ‘Hey, 45 yards, he’s going to make this kick.'” - Joe Brady after his team’s win against the LA Rams in their last game.
“We’re not happy with what happened today, and we’ve got to go do something about it.” - Klint Kubiak after his team’s loss against the Patriots in their last game.
Starting Lineups
Buffalo Bills
WR Coleman, Keon
WR Moore, DJ
WR Shakir, Khalil
TE Kincaid, Dalton
QB Allen, Josh
RB Cook III, James
Las Vegas Raiders
WR Nailor, Jalen
WR White, Cody
WR Tucker, Tre
TE Bowers, Brock
QB Cousins, Kirk
RB Jeanty, Ashton
FB Heyward, Connor
Statistical Leaders
Buffalo Bills
Passing: Josh Allen (1,249)
Rushing: James Cook III (532)
Receiving: Dalton Kincaid (277)
Touchdowns: Josh Allen (8)
Las Vegas Raiders
Passing: Kirk Cousins (1,269)
Rushing: Ashton Jeanty (291)
Receiving: Brock Bowers (312)
Touchdowns: Cody White (3)
Coaches:
Buffalo Bills: Joe Brady (1st season)
Las Vegas Raiders: Klint Kubiak (1st season)
Rod Pearson
About the Author:
Rod Pearson has been a rabid sports fan his entire life. He grew up in Ontario, and was skilled in both hockey and baseball, and pitched in an elite baseball league for many years. In 2022, Rod decided to hang up his glove, so that he could write about the sports he loves -- but from a gambling perspective. Join Rod every day as he breaks down the games to find the best betting value.
