Buffalo Bills vs Jacksonville Jaguars Prediction, Preview and Odds - 01/11/2026

Game Time: 1:00 pm ET, Sunday, January 11, 2026

Venue:  EverBank Stadium, Jacksonville, FL

Where to Watch:  CBS

DraftKings:  Point Spread:  Bills -1.5, Jaguars +1.5; Over/Under:  51.5 points

Bet365:  Point Spread:  Bills -1.5, Jaguars +1.5; Over/Under:  51.5 points

BetMGM:  Point Spread:  Bills -1.5, Jaguars +1.5; Over/Under:  51.5 points

Buffalo Bills:  12-5 (2nd place, AFC East)

Jacksonville Jaguars:  13-4 (1st place, AFC South)

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Buffalo Bills:  won their last game at home against the New York Jets 35-8.

Jacksonville Jaguars:  won their last game at home against the Tennessee Titans 41-7.

The Bills are entering this game with a 12-5 record overall and they have a 4-2 record in their divisional games too. They are 7-2 in their home games, 5-3 in their road games, and they are also 0-0 in their neutral site games this season, but they will be on the road for this game. They won their last game against the New York Jets 35-8. Mitchell Trubisky was the starting QB and he completed 22/29 passes for 259 passing yards, 4 touchdowns, and 0 interceptions. Ray Davis led the team in rushing yards with 151. Keon Coleman led the receivers with 49 receiving yards on 2 receptions. Dorian Williams led the defense in that game with 3 solo tackles and 4 assisted tackles while TJ Sanders led the defense in sacks with 1. No one on the defense came away with an interception for them in that one.

 

 

 

The Jaguars are entering this game with a 13-4 record overall and they have a 5-1 record in their divisional games too. They are 7-1 in their home games, 6-2 in their road games, and they are also 0-1 in their neutral site games this season, but they will be at home for this game. They won their last game against the Tennessee Titans 41-7. Trevor Lawrence was the starting QB and he completed 22/30 passes for 255 passing yards, 3 touchdowns, and 0 interceptions. Travis Etienne Jr. led the team in rushing yards with 32. Parker Washington led the receivers with 87 receiving yards on 5 receptions and 1 TD. Foyesade Oluokun led the defense in that game with 3 solo tackles and 5 assisted tackles while Dawuane Smoot led the defense in sacks with 1. Antonio Johnson came away with the only interception for them in that one.

The current betting odds have the Jaguars listed as a 1.5 point underdog in this game according to Draftkings Sportsbook. The Jaguars have looked great in their games this season with their 13-4 record overall which had them right at the top of the AFC South with one of the best records in the entire NFL. They have looked great on their home field too with their 7-1 home record this year. Meanwhile, the Bills have looked good in their games this season with their 12-5 record overall which had them right near the top of the AFC East. They have been a good road team too with their 5-3 road record this year. The Bills are off a 35-8 win over the Jets in their last one and they have looked really good over the last few weeks of the season. Their offense has been rolling all year with Josh Allen once again playing at a high level, but their defense has been a big issue for them all season. They don't have a good defense as they have been giving up a ton of points all year, and it could be an issue that they won't be able to overcome in this game. The Jags are off a 41-7 win over the Titans in their last one and they have been rolling in their games lately. They have won 8 games in a row now and they have some really good wins against top teams in the NFL too. Their offense has been rolling with Trevor Lawrence playing some of the best football of his career, and the defense has been great as they don't give up many points. The Bills have the experience along with one of the best QB's in the NFL to help them out here, but that defense is a big issue and could be the deciding factor in this game. The best way to place a bet here is on the Jaguars to cover the spread in this game. 

Bills Jaguars Prediction:  Our NFL Pick for Sunday, January 11, 2026 (1:00 pm ET start time) is Jaguars 28 Bills 17.

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Buffalo Bills: 0-6 ATS after a 2 game home stand. 6-10 ATS after a win by 14 or more points. 2-6 ATS on the road after allowing 14 points or less last game. 8-4 OVER in all games where the total is greater than or equal to 49.5. 10-2 OVER off a win against a division rival.

Jacksonville Jaguars: 8-3 ATS after 3 or more consecutive wins against the spread. 30-19 ATS in all games. 9-2 ATS after a win by 14 or more points. 11-4 ATS when playing against a good team (Win Pct. 60% to 75%). 9-2 OVER off a win against a division rival. 8-3 OVER after allowing 14 points or less last game.

Buffalo Bills:  T. White (CB) Injured - Illness. T. Grable (OT) Injured - Personal. D. Walker (DL) Injured - Illness. A. Epenesa (DL) Injured - Illness. J. Cook III (RB) Injured - Rest. M. Prater (K) Injured - Quad. J. Bosa (DL) Questionable - Hamstring. J. Poyer (S) Out - Hamstring. J. Phillips (DL) Questionable - Ankle. D. Jones (DL) Out - Calf. J. Allen (QB) Injured - Foot. T. Bernard (LB) Out - Calf. C. Lewis (CB) Injured - Hamstring. D. Knox (TE) Injured - Knee. R. Gilliam (FB) Injured - Illness. D. Kincaid (TE) Questionable - Knee.

Jacksonville Jaguars:  A. Armstead (DL) Injured - Hand. M. Brown (CB) Injured - Neck. E. Cleveland (OG) Injured - Shoulder. R. Hainsey (C) Injured - Groin. P. Mekari (OG) Out - Back. Y. Abdullah (LB) Injured - Back. G. Newsome II (CB) Injured - Shoulder. A. Harrison (OG) Injured - Illness. D. Striggow (DL) Injured - Ankle. J. McLeod (LB) Out - Ankle. B. Tuten (RB) Injured - Finger.

"It's an important week for us, obviously. Got to check the injury report because we've got some injuries popped up again. I think that's the first step, to know who's available for us. That'll be the first thing (Monday) morning item on the to-do list." - Sean McDermott after his team’s win against the Jets in their last game. 

“Today is the biggest game in franchise history because it’s the next one. That’s it — because it’s the next one. That’s been the mindset and mentality of this group. They’ve stayed even-keeled. There’s confidence. This team has confidence, but they’re not overlooking anybody, and they know that whoever comes here has to play us.” - Liam Coen after his team’s win against the Titans in their last game. 

WR Palmer, Joshua

WR Shavers, Tyrell

WR Shakir, Khalil

TE Knox, Dawson

QB Allen, Josh

RB Cook, James

FB Gilliam, Reggie

WR Thomas Jr., Brian

WR Meyers, Jakobi

WR Washington, Parker

TE Strange, Brenton

QB Lawrence, Trevor 

RB Etienne Jr., Travis

Passing: Josh Allen (3,668)

Rushing: James Cook (1,621)

Receiving: Khalil Shakir (719)

Touchdowns: James Cook (14)

Passing: Trevor Lawrence (4,007)

Rushing: Travis Etienne Jr. (1,107)

Receiving: Parker Washington (847)

Touchdowns: Travis Etienne Jr. (13)

Coaches:

Buffalo Bills: Sean McDermott (9th season)

Jacksonville Jaguars: Liam Coen (1st season)