Boston Red Sox vs New York Yankees Prediction, Preview and Odds - 06/06/2025

Game Time: 7:05 pm ET, Friday, June 6, 2025

Venue:  Yankee Stadium, Bronx, NY

Where to Watch:  MLBN

DraftKings:  Moneyline odds:  Red Sox +135, Yankees -160; Over/Under:  9 runs

Bet365:  Moneyline odds:  Red Sox +135, Yankees -160; Over/Under:  9 runs

BetMGM:  Moneyline odds:  Red Sox +135, Yankees -160; Over/Under:  9 runs

Boston Red Sox:  30-34 (4th place, AL East)

New York Yankees:  37-23 (1st place, AL East)

Do not miss out on our expert handicapper analysis! Matt Fargo is on a HOT STREAK in the MLB on a 31-28 MLB RUN for +$12,310 PROFIT! Make sure you check out his picks and many more from the expert handicappers featured in the Shop Picks section.

Boston Red Sox:  3-7 last 10

New York Yankees:  7-3 last 10

The Red Sox are entering this series off a win and lost their 3-game series against the Los Angeles Angels 2-1 in their last series. They enter this game with a 30-34 record overall and have a road record of 13-18. This is the series opener of a 3-game series with the Yankees on Friday and they have Thursday off as a day of rest. Their offense ranks 5th in the MLB with a .741 OPS. Lucas Giolito was their starting pitcher on Wednesday while Walker Buehler is making his start in this game on Friday. He is 4-3 with a 4.44 ERA this season. His team lost their last 2 straight games this season with him making an appearance. In his last MLB regular season start, he allowed 5 ER, 2 HR, and 2 BB with 6 Ks on 10 hits through 5.2 IP against the Atlanta Braves.

The Yankees lost their 3-game series against the Los Angeles Dodgers 2-1. They enter this game with a 37-23 record overall and have a home record of 19-10. This is the 1st game of a 3-game series with the Red Sox on Friday with the 3rd game of their series against the Cleveland Guardians still to be played on Thursday. The Yankees won the 1st game of that series on Tuesday and lost the 2nd game on Wednesday. Their offense ranks 2nd in the MLB with a .805 OPS. Max Fried is their starting pitcher on Thursday while Will Warren is making his start in this game on Friday. He is 3-3 with a 5.19 ERA this season. His team won 4 of their last 5 games this season with him making an appearance. In his last MLB regular season start, he allowed 7 earned runs, 1 homer, and 4 BB with 2 strikeouts on 6 hits through 1.1 innings played against the Los Angeles Dodgers.

The current betting odds have the Yankees listed as a favorite in this game according to Draftkings Sportsbook. The Yankees have looked really good in their games this season with their 37-23 record overall which has them right at the top of the AL East with one of the best records in the entire MLB. They have also looked great in their own ballpark this year with their 19-10 home record. Meanwhile, the Red Sox haven't looked good in their games this season with their 30-34 record overall which has them right near the bottom of the AL East. They haven't been a good road team either with their 13-18 road record. The Yankees have been the hotter team coming into this series as they are 7-3 in their last 10 games while the Red Sox are 3-7 and have been in a terrible slump. Buehler is on the mound for the Red Sox in this one and he hasn't looked great this season. He is 4-3 with a 4.44 ERA and has been giving up quite a few runs in his starts lately. He gave up 5 earned runs in his last start and the team has lost 2 games in a row with him starting too. They just lost their series against the Angels at home and now they are playing a much stronger team on the road where they haven't looked as good this year. Warren is on the mound for the Yankees and he hasn't looked great this season either. He is 3-3 with a 5.19 ERA and he did give up 7 earned runs in his last start, but the team has still won 4 of their last 5 games with him starting and he will be more likely to bounce back in this home game. The Yankees also have one of the best offenses in the MLB and they can take advantage of this slumping Red Sox team. The best way to place a bet here is on the Yankees to win this game. 

Red Sox Yankees Prediction:  Our MLB Pick for Friday, June 6, 2025 (7:05 pm ET start time) is Yankees 7 Red Sox 4.

Don't miss our champion handicappers free picks, best bets, and expert baseball picks today.  And if you enjoyed this Boston Red Sox New York Yankees prediction, be sure to drop by every day for our daily MLB projections and previews.

Boston Red Sox: 188-198 (-28.5 units) on the moneyline in all games. 143-145 (-15 units) on the moneyline against right-handed starters. 92-110 (-13.2 units) on the moneyline when playing against a team  with a winning record. 31-21 UNDER vs. a starting pitcher whose lasts less than 5 innings per start.

New York Yankees: 177-133 (+13.8 units) on the moneyline against right-handed starters. 143-107 (+6.3 units) on the moneyline vs. an AL team with an on base percentage .330 or worse. 127-90 (+15.7 units) on the moneyline in the first half of the season. 12-5 UNDER at home vs. poor fielding teams - averaging 0.75+ errors/game. 

Boston Red Sox:  N. Burdi (RP) Fifteen Day IL - Knee. J. Slaten (RP) Fifteen Day IL - Shoulder. L. Hendriks (RP) Fifteen Day IL - Hip. A. Bregman (3B) Ten Day IL - Quad. T. Casas (1B) Sixty Day IL - Knee. M. Yoshida (LF) Sixty Day IL - Shoulder. K. Crawford (SP) Sixty Day IL - Knee. T. Houck (SP) Fifteen Day IL - Flexor. C. Murphy (RP) Sixty Day IL - Elbow. P. Sandoval (SP) Sixty Day IL - Elbow.

New York Yankees:  J. Dominguez (LF) Day To Day - Thumb. L. Weaver (RP) Fifteen Day IL - Hamstring. O. Cabrera (3B) Ten Day IL - Ankle. G. Stanton (DH) Sixty Day IL - Elbow. M. Stroman (SP) Fifteen Day IL - Knee. J. Brubaker (SP) Sixty Day IL - Ribs. J. Cousins (RP) Sixty Day IL - Elbow. L. Gil (SP) Sixty Day IL - Back. G. Cole (SP) Sixty Day IL - Elbow.

“You saw Raffy put the ball in play. The ball went through. I'm not saying just give up your bat to weak contact, but the game will dictate what you do.” - Alex Cora after his team’s win against the LA Angels in their game on Wednesday.

"We just didn’t mount much offensively tonight. We really didn’t sting the ball much off [Ortiz] at all. We had a couple of chances that we weren’t able to cash in, and he kept us in the ballpark. Pretty slow night for us.” - Aaron Boone after his team’s loss against the Guardians in their game on Wednesday.

Jarren Duran (L) LF

Rafael Devers (L) DH

Wilyer Abreu (L) RF

Carlos Narváez (R) C

Marcelo Mayer (L) 3B

Abraham Toro (S) 1B

Ceddanne Rafaela (R) CF

David Hamilton (L) SS

Kristian Campbell (R) 2B

Trent Grisham (L) CF

Ben Rice (L) DH

Aaron Judge (R) RF

Cody Bellinger (L) LF

Paul Goldschmidt (R) 1B

Jazz Chisholm Jr. (L) 3B

Anthony Volpe (R) SS

Austin Wells (L) C

DJ LeMahieu (R) 2B

Batting Average:  Abraham Toro (.304)

Hits:  Jarren Duran (75)

Home Runs:  Wilyer Abreu (13)

RBI:  Rafael Devers (54)

Stolen Bases:  Jarren Duran (13)

Wins:  Garrett Crochet (5)

Saves:  Aroldis Chapman (9)

ERA:  Nick Burdi (0.00)

Batting Average:  Aaron Judge (.389)

Hits:  Aaron Judge (88)

Home Runs:  Aaron Judge (21)

RBI:  Aaron Judge (50)

Stolen Bases:  Jasson Domínguez (8)

Wins:  Carlos Rodón (8)

Saves:  Luke Weaver (8)

ERA:  Adam Ottavino (0.00)

Managers:

Boston Red Sox: Álex Cora (5th season)

New York Yankees: Aaron Boone (8th season)