Game Time: 4:07 pm ET, Wednesday, June 25, 2025
Venue: Angel Stadium, Anaheim, CA
Where to Watch: NESN, FDSW
Opening Odds at USA Sportsbooks
DraftKings: Moneyline odds: Red Sox +104, Angels -126; Over/Under: 9 runs
Bet365: Moneyline odds: Red Sox +105, Angels -125; Over/Under: 9 runs
BetMGM: Moneyline odds: Red Sox +105, Angels -125; Over/Under: 9 runs
Season Record
Boston Red Sox: 40-40 (4th place, AL East)
Los Angeles Angels: 38-40 (3rd place, AL West)
Do not miss out on our expert handicapper analysis! Brian Bitler is on a HOT STREAK in the MLB on an 11-4 MLB RUN for +$7,800 PROFIT! Make sure you check out his picks and many more from the expert handicappers featured in the Shop Picks section.
Recent Form
Boston Red Sox: 6-4 last 10
Los Angeles Angels: 5-5 last 10
Boston Red Sox vs Los Angeles Angels Preview and Analysis
The Red Sox are entering this series off a loss and lost their 3-game series against the San Francisco Giants 2-1 in their last series. They enter this game with a 40-40 record overall and have a road record of 18-23. This is the series finale of a 3-game series with the Angels on Wednesday with the 2nd game still to be played on Tuesday. The Red Sox lost the series opener of this series on Monday. Their offense ranks 7th in the MLB with a .741 OPS. Garrett Crochet is their starting pitcher on Tuesday while Richard Fitts is making his start in this game on Wednesday. He is 0-3 with a 4.71 ERA this season. His team lost their last 5 straight games this season with him making an appearance. In his last MLB regular season start, he allowed 5 ER, 3 HR, and 1 BB with 0 SO on 4 hits through 1 IP against the Los Angeles Angels.
The Angels are entering this series off a loss and lost their 3-game series against the Houston Astros 2-1 in their last series. They enter this game with a 38-40 record overall and have a home record of 17-18. This is the 3rd game of a 3-game series with the Red Sox on Wednesday with the 2nd game of this series still to be played on Tuesday. The Angels won the 1st game of this series on Monday. Their offense ranks 23rd in the MLB with a .694 OPS. Tyler Anderson is their starting pitcher on Tuesday while Yusei Kikuchi is making his start in this game on Wednesday. He is 2-6 with a 3.01 ERA this season. His team lost their last 2 straight games this season with him making an appearance. In his last MLB regular season start, he allowed 2 earned runs, 2 homers, and 0 walks with 9 strikeouts on 6 hits through 7 innings pitched against the Houston Astros.
Red Sox vs Angels Prediction
The current betting odds have the Angels listed as a slight favorite in this game according to Draftkings Sportsbook. The Red Sox have looked good in their games this season with their 40-40 record overall, but that record has them near the bottom of the AL East in a competitive division. They haven't been a great road team either with their 18-23 road record this season. Meanwhile, the Angels haven't looked great in their games this season with their 38-40 record overall which has them right near the bottom of the AL West. They haven't looked good in their own ballpark either with their 17-18 home record this year. The Red Sox have been the hotter team coming into this series, but they did lose the 1st game of this series and the Angels definitely have the better pitching matchup to take advantage of here. The Angels are going with Kikuchi in this one and he hasn't looked bad this season. He is 2-6 with a 3.01 ERA and hasn't been giving up many runs in his starts despite the losses. The team has lost 2 games in a row now with him starting too, but he only gave up 2 earned runs in his last start which has been a common theme for him lately and he is due for a win with the way the Angels offense has been hitting. The Red Sox are also going with Fitts in this one and he hasn't looked great this season. He is 0-3 with a 4.71 ERA and he hasn't pitched that much this year. He was terrible in his last start as he gave up 5 earned runs and the team has had no success with him starting either, losing all 5 games he has started in this season. The Angels have the much better pitching matchup in this one and the momentum with their offense. The best way to place a bet here is on the Angels to win this game.
Red Sox Angels Prediction: Our MLB Pick for Wednesday, June 25, 2025 (4:07 pm ET start time) is Angels 7 Red Sox 4.
Don't miss our champion handicappers free picks, best bets, and expert baseball picks today. And if you enjoyed this Boston Red Sox Los Angeles Angels prediction, be sure to drop by every day for our daily MLB projections and previews.
MLB Betting Trends
Boston Red Sox: 198-204 (-21.7 units) on the moneyline in all games. 105-116 (-12.9 units) on the moneyline when the money line is +125 to -125. 50-54 (-7.2 units) on the moneyline against left-handed starters. 10-5 OVER as a road underdog of +100 to +150.
Los Angeles Angels: 75-72 (+14.8 units) on the moneyline when the total is 9 to 9.5. 62-78 (+2.8 units) on the moneyline vs. an AL starting pitcher whose WHIP is 1.300 or better. 41-32 (+14.6 units) on the moneyline in June games. 15-8 OVER in day games.
Key Injuries
Boston Red Sox: H. Dobbins (SP) Fifteen Day IL - Elbow. J. Hicks (SP) Fifteen Day IL - Toe. J. Winckowski (RP) Sixty Day IL - Elbow. N. Burdi (RP) Fifteen Day IL - Knee. T. Casas (1B) Sixty Day IL - Knee. J. Slaten (RP) Fifteen Day IL - Shoulder. L. Hendriks (RP) Fifteen Day IL - Hip. A. Bregman (3B) Ten Day IL - Quad. M. Yoshida (LF) Sixty Day IL - Shoulder. K. Crawford (SP) Sixty Day IL - Knee. T. Houck (SP) Fifteen Day IL - Flexor. C. Murphy (RP) Sixty Day IL - Elbow. P. Sandoval (SP) Sixty Day IL - Elbow.
Los Angeles Angels: J. Soler (RF) Ten Day IL - Back. C. Taylor (CF) Ten Day IL - Hand. Y. Moncada (3B) Ten Day IL - Knee. R. Stephenson (RP) Fifteen Day IL - Bicep. B. Joyce (RP) Sixty Day IL - Shoulder. A. Rendon (3B) Sixty Day IL - Hip.
Notable Quotes
“We’ll talk about it. But his second and third inning were really good. Velocity was up and the movement pitches were great, but he knows it. We talked a little bit down here. There’s a few things mechanically that he feels like he needs to do better, but he’ll be ready for the next one.” - Alex Cora on Walker Buehler after his team’s loss against the LA Angels in their game on Monday.
“They were huge. Det coming into that situation right there, that was huge. And with Sammy, we’ve seen it before but it’s nice to see it coming back like that [after injury issues]. For him to get in that situation and handle it was good to see.” - Acting manager Ray Montgomery after his team’s win against the Red Sox in their game on Monday.
Starting Lineups
Boston Red Sox
Jarren Duran (L) LF
Abraham Toro (S) 1B
Roman Anthony (L) DH
Trevor Story (R) SS
Wilyer Abreu (L) RF
Ceddanne Rafaela (R) CF
Marcelo Mayer (L) 3B
Connor Wong (R) C
David Hamilton (L) 2B
Los Angeles Angels
Zach Neto (R) SS
Nolan Schanuel (L) 1B
Mike Trout (R) DH
Taylor Ward (R) LF
Travis d'Arnaud (R) C
Jo Adell (R) CF
LaMonte Wade Jr. (L) RF
Luis Rengifo (S) 3B
Christian Moore (R) 2B
Statistical Leaders
Boston Red Sox
Batting Average: Nate Eaton (.750)
Hits: Jarren Duran (86)
Home Runs: Wilyer Abreu (13)
RBI: Trevor Story (39)
Stolen Bases: Jarren Duran (15)
Wins: Garrett Crochet (7)
Saves: Aroldis Chapman (14)
ERA: Nick Burdi (0.00)
Los Angeles Angels
Batting Average: Zach Neto (.278)
Hits: Nolan Schanuel (77)
Home Runs: Taylor Ward (19)
RBI: Taylor Ward (53)
Stolen Bases: Zach Neto (13)
Wins: Kyle Hendricks (5)
Saves: Kenley Jansen (15)
ERA: Sam Aldegheri (0.00)
Managers:
Boston Red Sox: Álex Cora (5th season)
Los Angeles Angels: Ron Washington (2nd season)